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Preliminary study of brain glucose metabolism changes in patients with lung cancer of different histological types.

Li WL, Fu C, Xuan A, Shi DP, Gao YJ, Zhang J, Xu JL - Chin. Med. J. (2015)

Bottom Line: The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus.Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group.The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

ABSTRACT

Background: Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors. This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types.

Methods: One hundred and twenty patients with primary untreated lung cancer, who visited People's Hospital of Zhengzhou University from February 2012 to July 2013, were divided into three groups based on histological types confirmed by biopsy or surgical pathology, which included adenocarcinoma (52 cases), squamous cell carcinoma (43 cases), and small-cell carcinoma (25 cases). The whole body 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) of these cases was retrospectively studied. The brain PET data of three groups were analyzed individually using statistical parametric maps (SPM) software, with 50 age-matched and gender-matched healthy controls for comparison.

Results: The brain resting glucose metabolism in all three lung cancer groups showed regional cerebral metabolic reduction. The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group. The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).

Conclusions: The brain resting glucose metabolism in patients with lung cancer shows regional cerebral metabolic reduction and the brain hypo-metabolic changes are related to the histological types of lung cancer.

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Related in: MedlinePlus

The visualization of statistical parametric map (SPM) in the patients with lung cancer. (a) The visualization of SPM in patients with lung adenocarcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle, and inferior temporal gyrus and left middle and superior frontal gyrus. Total voxel value of the involved regions was 1217. (b) The visualization of SPM in patients with lung squamous cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle and superior temporal gyrus and the left middle and superior frontal gyrus. Total voxel value of the involved regions was 1292. (c) The visualization of SPM in patients with lung small-cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left superior middle and inferior temporal gyrus, left middle and superior frontal gyrus, right middle and superior temporal gyrus, right inferior parietal gyrus and the right hippocampus. Total voxel value of the involved regions was 3255.
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Figure 1: The visualization of statistical parametric map (SPM) in the patients with lung cancer. (a) The visualization of SPM in patients with lung adenocarcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle, and inferior temporal gyrus and left middle and superior frontal gyrus. Total voxel value of the involved regions was 1217. (b) The visualization of SPM in patients with lung squamous cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle and superior temporal gyrus and the left middle and superior frontal gyrus. Total voxel value of the involved regions was 1292. (c) The visualization of SPM in patients with lung small-cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left superior middle and inferior temporal gyrus, left middle and superior frontal gyrus, right middle and superior temporal gyrus, right inferior parietal gyrus and the right hippocampus. Total voxel value of the involved regions was 3255.

Mentions: Compared with the healthy controls, the brain PET imaging in all three lung cancer groups showed a relative reduction of regional cerebral resting glucose metabolism (P < 0.05). The hypo-metabolic cerebral regions were mainly distributed at the left superior-middle frontal gyrus, bilateral superior-middle temporal gyrus or/and inferior-middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group [Figure 1]. And there were statistically significant differences among the voxel values in abnormal activation cerebral regions of three lung cancer groups (F = 87.53, P < 0.01). The area of total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value of 3255) was significantly larger than those in the adenocarcinoma group (total voxel value of 1217, t = 14.33, P < 0.01) and the squamous cell carcinoma group (total voxel value of 1292, t = 10.07, P < 0.01). And there was no statistically significant difference of abnormal activation cerebral regions between adenocarcinoma and the squamous cell carcinoma groups (t = 0.764, P = 0.525) [Table 1].


Preliminary study of brain glucose metabolism changes in patients with lung cancer of different histological types.

Li WL, Fu C, Xuan A, Shi DP, Gao YJ, Zhang J, Xu JL - Chin. Med. J. (2015)

The visualization of statistical parametric map (SPM) in the patients with lung cancer. (a) The visualization of SPM in patients with lung adenocarcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle, and inferior temporal gyrus and left middle and superior frontal gyrus. Total voxel value of the involved regions was 1217. (b) The visualization of SPM in patients with lung squamous cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle and superior temporal gyrus and the left middle and superior frontal gyrus. Total voxel value of the involved regions was 1292. (c) The visualization of SPM in patients with lung small-cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left superior middle and inferior temporal gyrus, left middle and superior frontal gyrus, right middle and superior temporal gyrus, right inferior parietal gyrus and the right hippocampus. Total voxel value of the involved regions was 3255.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837858&req=5

Figure 1: The visualization of statistical parametric map (SPM) in the patients with lung cancer. (a) The visualization of SPM in patients with lung adenocarcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle, and inferior temporal gyrus and left middle and superior frontal gyrus. Total voxel value of the involved regions was 1217. (b) The visualization of SPM in patients with lung squamous cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left middle and inferior temporal gyrus, right middle and superior temporal gyrus and the left middle and superior frontal gyrus. Total voxel value of the involved regions was 1292. (c) The visualization of SPM in patients with lung small-cell carcinoma. The cerebral regions of reduced brain glucose metabolism (red areas) were distributed in the left superior middle and inferior temporal gyrus, left middle and superior frontal gyrus, right middle and superior temporal gyrus, right inferior parietal gyrus and the right hippocampus. Total voxel value of the involved regions was 3255.
Mentions: Compared with the healthy controls, the brain PET imaging in all three lung cancer groups showed a relative reduction of regional cerebral resting glucose metabolism (P < 0.05). The hypo-metabolic cerebral regions were mainly distributed at the left superior-middle frontal gyrus, bilateral superior-middle temporal gyrus or/and inferior-middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group [Figure 1]. And there were statistically significant differences among the voxel values in abnormal activation cerebral regions of three lung cancer groups (F = 87.53, P < 0.01). The area of total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value of 3255) was significantly larger than those in the adenocarcinoma group (total voxel value of 1217, t = 14.33, P < 0.01) and the squamous cell carcinoma group (total voxel value of 1292, t = 10.07, P < 0.01). And there was no statistically significant difference of abnormal activation cerebral regions between adenocarcinoma and the squamous cell carcinoma groups (t = 0.764, P = 0.525) [Table 1].

Bottom Line: The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus.Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group.The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

ABSTRACT

Background: Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors. This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types.

Methods: One hundred and twenty patients with primary untreated lung cancer, who visited People's Hospital of Zhengzhou University from February 2012 to July 2013, were divided into three groups based on histological types confirmed by biopsy or surgical pathology, which included adenocarcinoma (52 cases), squamous cell carcinoma (43 cases), and small-cell carcinoma (25 cases). The whole body 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) of these cases was retrospectively studied. The brain PET data of three groups were analyzed individually using statistical parametric maps (SPM) software, with 50 age-matched and gender-matched healthy controls for comparison.

Results: The brain resting glucose metabolism in all three lung cancer groups showed regional cerebral metabolic reduction. The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group. The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).

Conclusions: The brain resting glucose metabolism in patients with lung cancer shows regional cerebral metabolic reduction and the brain hypo-metabolic changes are related to the histological types of lung cancer.

Show MeSH
Related in: MedlinePlus