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Early detection of regional and global left ventricular myocardial function using strain and strain-rate imaging in patients with metabolic syndrome.

Wang Q, Sun QW, Wu D, Yang MW, Li RJ, Jiang B, Yang J, Li ZA, Wang Y, Yang Y - Chin. Med. J. (2015)

Bottom Line: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function.On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function.Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China.

ABSTRACT

Background: Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function.

Methods: Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S), peak systolic strain-rate (SR-s), peak diastolic strain-rate (SR-e).

Results: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.

Conclusion: In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

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Strain and strain-rate imaging from the basal and mid myocardial segments from a study subject.
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Figure 4: Strain and strain-rate imaging from the basal and mid myocardial segments from a study subject.

Mentions: Increased myocardial stiffness and reduce myocardial deformation ability, S and SR will reduce. In our study, S and SR were all declined in MS [Table 3], while the papillary muscle level of the S and SR were higher than those of the mitral level [Figure 4]. So there were regional myocardial dysfunctions in patients with MS. The impact of sub-clinical cardiac involvement in MS remains to be assessed. MS may have decreases of myocardial systolic and early diastolic velocities on TDI, even if they appear to have normal systolic and diastolic function on conventional echocardiography.[25]


Early detection of regional and global left ventricular myocardial function using strain and strain-rate imaging in patients with metabolic syndrome.

Wang Q, Sun QW, Wu D, Yang MW, Li RJ, Jiang B, Yang J, Li ZA, Wang Y, Yang Y - Chin. Med. J. (2015)

Strain and strain-rate imaging from the basal and mid myocardial segments from a study subject.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837843&req=5

Figure 4: Strain and strain-rate imaging from the basal and mid myocardial segments from a study subject.
Mentions: Increased myocardial stiffness and reduce myocardial deformation ability, S and SR will reduce. In our study, S and SR were all declined in MS [Table 3], while the papillary muscle level of the S and SR were higher than those of the mitral level [Figure 4]. So there were regional myocardial dysfunctions in patients with MS. The impact of sub-clinical cardiac involvement in MS remains to be assessed. MS may have decreases of myocardial systolic and early diastolic velocities on TDI, even if they appear to have normal systolic and diastolic function on conventional echocardiography.[25]

Bottom Line: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function.On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function.Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China.

ABSTRACT

Background: Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function.

Methods: Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S), peak systolic strain-rate (SR-s), peak diastolic strain-rate (SR-e).

Results: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.

Conclusion: In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

Show MeSH
Related in: MedlinePlus