Limits...
New classification of Herlyn-Werner-Wunderlich syndrome.

Zhu L, Chen N, Tong JL, Wang W, Zhang L, Lang JH - Chin. Med. J. (2015)

Bottom Line: The clinical details associated with these two types are distinctly different.HWWS patients should be differentiated according to these two classifications.The two classifications could be generalized by gynecologists world-wide.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

ABSTRACT

Background: Uterus didelphys and blind hemivagina associated with ipsilateral renal agenesis are collectively known as Herlyn-Werner-Wunderlich syndrome (HWWS). In the literature, the syndrome often appears as a single case report or as a small series. In our study, we reviewed the characteristics of all HWWS patients at Peking Union Medical College Hospital (PUMCH) and suggested a new classification for this syndrome because the clinical characteristics differed significantly between the completely and incompletely obstructed vaginal septum. This new classification allows for earlier diagnosis and treatment.

Methods: From January 1986 to March 2013, all diagnosed cases of HWWS at PUMCH were reviewed. A retrospective long-term follow-up study of the clinical presentation, surgical prognosis, and pregnancy outcomes was performed. Statistical analyses were performed using SPSS, version 15.0 (IBM, Armonk, NY, USA). Between-group comparisons were performed using the χ2 test, Fisher's exact test, and the t-test. The significance level for all analyses was set at P < 0.05.

Results: The clinical data from 79 patients with HWWS were analyzed until March 31, 2013. According to our newly identified characteristics, we recommend that the syndrome be classified by the complete or incomplete obstruction of the hemivagina as follows: Classification 1, a completely obstructed hemivagina and Classification 2, an incompletely obstructed hemivagina. The clinical details associated with these two types are distinctly different.

Conclusions: HWWS patients should be differentiated according to these two classifications. The two classifications could be generalized by gynecologists world-wide.

Show MeSH

Related in: MedlinePlus

Classification 2.1, partial reabsorption of the vaginal septum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4837842&req=5

Figure 3: Classification 2.1, partial reabsorption of the vaginal septum.

Mentions: In this classification, a small communication exists between the two vaginas, which make the vaginal cavity behind the septum incompletely obstructed. The uterus behind the septum is completely isolated from the contralateral uterus. The menses can outflow through the small communication, but the drainage is impeded. These patients have a later age of onset. The attack often comes years after menarche. Purulent or bloody vaginal discharge can be the chief complaints. Patients often have ascending genital system infection [Figure 3].


New classification of Herlyn-Werner-Wunderlich syndrome.

Zhu L, Chen N, Tong JL, Wang W, Zhang L, Lang JH - Chin. Med. J. (2015)

Classification 2.1, partial reabsorption of the vaginal septum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837842&req=5

Figure 3: Classification 2.1, partial reabsorption of the vaginal septum.
Mentions: In this classification, a small communication exists between the two vaginas, which make the vaginal cavity behind the septum incompletely obstructed. The uterus behind the septum is completely isolated from the contralateral uterus. The menses can outflow through the small communication, but the drainage is impeded. These patients have a later age of onset. The attack often comes years after menarche. Purulent or bloody vaginal discharge can be the chief complaints. Patients often have ascending genital system infection [Figure 3].

Bottom Line: The clinical details associated with these two types are distinctly different.HWWS patients should be differentiated according to these two classifications.The two classifications could be generalized by gynecologists world-wide.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

ABSTRACT

Background: Uterus didelphys and blind hemivagina associated with ipsilateral renal agenesis are collectively known as Herlyn-Werner-Wunderlich syndrome (HWWS). In the literature, the syndrome often appears as a single case report or as a small series. In our study, we reviewed the characteristics of all HWWS patients at Peking Union Medical College Hospital (PUMCH) and suggested a new classification for this syndrome because the clinical characteristics differed significantly between the completely and incompletely obstructed vaginal septum. This new classification allows for earlier diagnosis and treatment.

Methods: From January 1986 to March 2013, all diagnosed cases of HWWS at PUMCH were reviewed. A retrospective long-term follow-up study of the clinical presentation, surgical prognosis, and pregnancy outcomes was performed. Statistical analyses were performed using SPSS, version 15.0 (IBM, Armonk, NY, USA). Between-group comparisons were performed using the χ2 test, Fisher's exact test, and the t-test. The significance level for all analyses was set at P < 0.05.

Results: The clinical data from 79 patients with HWWS were analyzed until March 31, 2013. According to our newly identified characteristics, we recommend that the syndrome be classified by the complete or incomplete obstruction of the hemivagina as follows: Classification 1, a completely obstructed hemivagina and Classification 2, an incompletely obstructed hemivagina. The clinical details associated with these two types are distinctly different.

Conclusions: HWWS patients should be differentiated according to these two classifications. The two classifications could be generalized by gynecologists world-wide.

Show MeSH
Related in: MedlinePlus