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Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.

Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM, Li XY, Sun YL, Chen H - Chin. Med. J. (2015)

Bottom Line: The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.Three hundred and sixty biopsy tissues were obtained.The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

ABSTRACT

Background: Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic (TEM) examination, it is important to have specific knowledge about contrast-enhanced ultrasound. Methods : Ultrasound contrast was applied in operations of 120 cases of brain glioma, to evaluate the degree of tumor resection. Biopsy tissues were obtained the suspicious residual tumors surrounding the tumor cavity. The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.

Results: There were 44 cases of low-grade gliomas and 76 cases of high-grade gliomas. Three hundred and sixty biopsy tissues were obtained. The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%. The consistency coefficient of the ultrasound contrast diagnosis and TEM examination results was 0.584 (Kappa = 0.584), which was between 0.4 and 0.6, therefore it was of medium consistency. Conclusions : Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of tumor. The consistency of the residual tumor rate detected, respectively, by ultrasound contrast and TEM examination was of medium consistency. The application of intraoperative ultrasound contrast can improve the resection rate of brain glioma.

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The banded medium-strong echo area and its surrounding normal brain tissue examined by ultrasound contrast showed homogeneous enhancement (marked by the triangle in the Figure). It was not considered as tumor residue by ultrasound contrast, while was proved to be gliocyteproliferation by postoperative TEM examination.
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Figure 4: The banded medium-strong echo area and its surrounding normal brain tissue examined by ultrasound contrast showed homogeneous enhancement (marked by the triangle in the Figure). It was not considered as tumor residue by ultrasound contrast, while was proved to be gliocyteproliferation by postoperative TEM examination.

Mentions: There were altogether 360 samples in this operation and 87 tumor residues detected by the intraoperative ultrasound imaging [Figure 3], 69 residues of which were verified by the TEM examination. The sensitivity of ultrasound contrast was 69/111 = 62.2%. There were 273 samples without tumor residues detected by intraoperative ultrasound contrast [Figure 4], 231 of which were verified by the TEM examination. The specificity of ultrasound contrast was 231/249 = 92.8%. The comparison and contrast of the results obtained, respectively, by ultrasound contrast and TEM examination are shown in [Table 1].


Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.

Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM, Li XY, Sun YL, Chen H - Chin. Med. J. (2015)

The banded medium-strong echo area and its surrounding normal brain tissue examined by ultrasound contrast showed homogeneous enhancement (marked by the triangle in the Figure). It was not considered as tumor residue by ultrasound contrast, while was proved to be gliocyteproliferation by postoperative TEM examination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837836&req=5

Figure 4: The banded medium-strong echo area and its surrounding normal brain tissue examined by ultrasound contrast showed homogeneous enhancement (marked by the triangle in the Figure). It was not considered as tumor residue by ultrasound contrast, while was proved to be gliocyteproliferation by postoperative TEM examination.
Mentions: There were altogether 360 samples in this operation and 87 tumor residues detected by the intraoperative ultrasound imaging [Figure 3], 69 residues of which were verified by the TEM examination. The sensitivity of ultrasound contrast was 69/111 = 62.2%. There were 273 samples without tumor residues detected by intraoperative ultrasound contrast [Figure 4], 231 of which were verified by the TEM examination. The specificity of ultrasound contrast was 231/249 = 92.8%. The comparison and contrast of the results obtained, respectively, by ultrasound contrast and TEM examination are shown in [Table 1].

Bottom Line: The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.Three hundred and sixty biopsy tissues were obtained.The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

ABSTRACT

Background: Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic (TEM) examination, it is important to have specific knowledge about contrast-enhanced ultrasound. Methods : Ultrasound contrast was applied in operations of 120 cases of brain glioma, to evaluate the degree of tumor resection. Biopsy tissues were obtained the suspicious residual tumors surrounding the tumor cavity. The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.

Results: There were 44 cases of low-grade gliomas and 76 cases of high-grade gliomas. Three hundred and sixty biopsy tissues were obtained. The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%. The consistency coefficient of the ultrasound contrast diagnosis and TEM examination results was 0.584 (Kappa = 0.584), which was between 0.4 and 0.6, therefore it was of medium consistency. Conclusions : Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of tumor. The consistency of the residual tumor rate detected, respectively, by ultrasound contrast and TEM examination was of medium consistency. The application of intraoperative ultrasound contrast can improve the resection rate of brain glioma.

Show MeSH
Related in: MedlinePlus