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Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.

Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM, Li XY, Sun YL, Chen H - Chin. Med. J. (2015)

Bottom Line: The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.Three hundred and sixty biopsy tissues were obtained.The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

ABSTRACT

Background: Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic (TEM) examination, it is important to have specific knowledge about contrast-enhanced ultrasound. Methods : Ultrasound contrast was applied in operations of 120 cases of brain glioma, to evaluate the degree of tumor resection. Biopsy tissues were obtained the suspicious residual tumors surrounding the tumor cavity. The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.

Results: There were 44 cases of low-grade gliomas and 76 cases of high-grade gliomas. Three hundred and sixty biopsy tissues were obtained. The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%. The consistency coefficient of the ultrasound contrast diagnosis and TEM examination results was 0.584 (Kappa = 0.584), which was between 0.4 and 0.6, therefore it was of medium consistency. Conclusions : Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of tumor. The consistency of the residual tumor rate detected, respectively, by ultrasound contrast and TEM examination was of medium consistency. The application of intraoperative ultrasound contrast can improve the resection rate of brain glioma.

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Tumor cells distributed diffusedly while some of them aggregated. Tumor cells were ill-defined with little cytoplasm, nucleus of varied size, and myelin with diffusively degenerated mesenchyme. It was consistent with the features of star-oligodendroglioma.
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Figure 1: Tumor cells distributed diffusedly while some of them aggregated. Tumor cells were ill-defined with little cytoplasm, nucleus of varied size, and myelin with diffusively degenerated mesenchyme. It was consistent with the features of star-oligodendroglioma.

Mentions: The common features of the astrocytoma tumor cells were as followed: chromatin inside the nucleus was evenly distributed and there were glial filaments of varying amounts inside the cytoplasm and cell protrusion, including hairy cell type and endomorphytype tumor cells [Figure 1]; the nucleus of glioblastoma tumor cells were large but irregular. Its nuclear membrane was in the shape of invaginated serrate and multicores, megakaryocytes, weird nucleus tumor cells, and intranuclear pseudoinclusion could be commonly seen inside the membrane. There were many unevenly distributed heterochromatin and the inter chromatin granules with reticular or rod-shaped prominent nucleoli or multiple nucleoli could also be seen [Figure 2].


Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.

Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM, Li XY, Sun YL, Chen H - Chin. Med. J. (2015)

Tumor cells distributed diffusedly while some of them aggregated. Tumor cells were ill-defined with little cytoplasm, nucleus of varied size, and myelin with diffusively degenerated mesenchyme. It was consistent with the features of star-oligodendroglioma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837836&req=5

Figure 1: Tumor cells distributed diffusedly while some of them aggregated. Tumor cells were ill-defined with little cytoplasm, nucleus of varied size, and myelin with diffusively degenerated mesenchyme. It was consistent with the features of star-oligodendroglioma.
Mentions: The common features of the astrocytoma tumor cells were as followed: chromatin inside the nucleus was evenly distributed and there were glial filaments of varying amounts inside the cytoplasm and cell protrusion, including hairy cell type and endomorphytype tumor cells [Figure 1]; the nucleus of glioblastoma tumor cells were large but irregular. Its nuclear membrane was in the shape of invaginated serrate and multicores, megakaryocytes, weird nucleus tumor cells, and intranuclear pseudoinclusion could be commonly seen inside the membrane. There were many unevenly distributed heterochromatin and the inter chromatin granules with reticular or rod-shaped prominent nucleoli or multiple nucleoli could also be seen [Figure 2].

Bottom Line: The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.Three hundred and sixty biopsy tissues were obtained.The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

ABSTRACT

Background: Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic (TEM) examination, it is important to have specific knowledge about contrast-enhanced ultrasound. Methods : Ultrasound contrast was applied in operations of 120 cases of brain glioma, to evaluate the degree of tumor resection. Biopsy tissues were obtained the suspicious residual tumors surrounding the tumor cavity. The sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination results.

Results: There were 44 cases of low-grade gliomas and 76 cases of high-grade gliomas. Three hundred and sixty biopsy tissues were obtained. The sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%, while the specificity degree of it was 92.8%. The consistency coefficient of the ultrasound contrast diagnosis and TEM examination results was 0.584 (Kappa = 0.584), which was between 0.4 and 0.6, therefore it was of medium consistency. Conclusions : Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of tumor. The consistency of the residual tumor rate detected, respectively, by ultrasound contrast and TEM examination was of medium consistency. The application of intraoperative ultrasound contrast can improve the resection rate of brain glioma.

Show MeSH
Related in: MedlinePlus