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Prognostic factors predicting the postoperative survival period following treatment for primary retroperitoneal liposarcoma.

Zhao X, Li P, Huang X, Chen L, Liu N, She Y - Chin. Med. J. (2015)

Bottom Line: The factors that were significantly associated with prognosis in the univariate analysis were age (as a categorical variable) (P = 0.006), modus operandi (P = 0.000), histologic subtype (P = 0.000), tumor grade (P = 0.000), ascites (P = 0.000), postoperative metastasis (P = 0.000) and adjuvant therapy (P = 0.030).However, in the multivariate analysis, the modus operandi (P = 0.000), tumor grade (P = 0.006), ascites (P = 0.027), postoperative metastasis (P = 0.023) and age (as a categorical variable) (P = 0.002) were the only significant predictors of survival.High grade, old age (≥ 60 years old), postoperative metastasis, and ascites predict poor prognoses.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

ABSTRACT

Background: Liposarcomas, which represent 20% of all adult sarcomas, are the most common histological type of malignant soft tissue tumors. The aim of this study was to define the prognostic factors that predict the postoperative survival period for patients with primary retroperitoneal liposarcoma.

Methods: The clinical data and prognoses of 71 patients with primary retroperitoneal liposarcoma who were treated in the General Hospital of the People's Liberation Army of China between January 1, 2000 and December 31, 2007 were retrospectively reviewed and analyzed.

Results: The primary tumor from each patient was resected; 54.9% (39/71) were deemed R0 resections, 31.0% (22/71) were R1 resections and 14.1% (10/71) were deemed R2 resections (palliative operations). The median follow up was 68 months (range: 1-160 months). Of the patients who received an R1 or R2 resection of their primary tumor, 96.7% (59/61) had tumor recurrence. The 1-year, 3-year, and 5-year recurrence-free rates were 77.0%, 29.8% and 19.7%, respectively. As of April 2013, 53 of the 71 patients had died from tumor recurrence. The overall 1-year, 3-year, 5-year, and 10-year survival rates were 88.7%, 76.1%, 61.7%, and 30.4%, respectively. The factors that were significantly associated with prognosis in the univariate analysis were age (as a categorical variable) (P = 0.006), modus operandi (P = 0.000), histologic subtype (P = 0.000), tumor grade (P = 0.000), ascites (P = 0.000), postoperative metastasis (P = 0.000) and adjuvant therapy (P = 0.030). However, in the multivariate analysis, the modus operandi (P = 0.000), tumor grade (P = 0.006), ascites (P = 0.027), postoperative metastasis (P = 0.023) and age (as a categorical variable) (P = 0.002) were the only significant predictors of survival.

Conclusions: Complete resection remains the most effective method for treating liposarcoma. High grade, old age (≥ 60 years old), postoperative metastasis, and ascites predict poor prognoses.

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Related in: MedlinePlus

Survival rates as a function of age (≥60 years old vs. <60 years old, P = 0.002 RR = 2.93 [95% confidence interval 1.47, 5.86], 71 patients).
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Figure 5: Survival rates as a function of age (≥60 years old vs. <60 years old, P = 0.002 RR = 2.93 [95% confidence interval 1.47, 5.86], 71 patients).

Mentions: The variables that were identified as significant in the univariate analysis, such as age (as a categorical variable), modus operandi, histological subtype, tumor grade, ascites, postoperative distant metastasis, and adjuvant therapy, were entered into a Cox model to define the independent factors that predict the postoperative survival time. However, the histological subtype failed the proportional hazards assumption test (histological subtype * LN [T_] X2 = 7.208 P = 0.007), and the results observed for adjuvant therapy were inconsistent with this. Consequently, both of these variables were excluded from the Cox model. As a result, a total of five variables, namely age (as a categorical variable), modus operandi, tumor grade, ascites, and postoperative distant metastasis, were included in the Cox model. With multivariate analysis, modus operandi (i.e. R0 resection vs. R1 resection vs. R2 resection, P = 0.000, RR = 3.21 [95% confidence interval 1.90, 5.42], [Figure 1]), tumor grade (i.e. high grade vs. low grade, P = 0.006, RR = 2.70 [1.34, 5.45], [Figure 2]), ascites (i.e. Yes vs. No, P = 0.027, RR = 6.98 [1.24, 39.20], [Figure 3]), postoperative metastasis (i.e. Yes vs. No, P = 0.023, RR = 4.11 [1.22, 13.87], [Figure 4] and age (as a categorical variable) (i.e. ≥60 years old vs. <60 years old, P = 0.002, RR = 2.93 [1.47, 5.86], [Figure 5]) were all independent factors that significantly predicted the postoperative survival time [Table 2].


Prognostic factors predicting the postoperative survival period following treatment for primary retroperitoneal liposarcoma.

Zhao X, Li P, Huang X, Chen L, Liu N, She Y - Chin. Med. J. (2015)

Survival rates as a function of age (≥60 years old vs. <60 years old, P = 0.002 RR = 2.93 [95% confidence interval 1.47, 5.86], 71 patients).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837826&req=5

Figure 5: Survival rates as a function of age (≥60 years old vs. <60 years old, P = 0.002 RR = 2.93 [95% confidence interval 1.47, 5.86], 71 patients).
Mentions: The variables that were identified as significant in the univariate analysis, such as age (as a categorical variable), modus operandi, histological subtype, tumor grade, ascites, postoperative distant metastasis, and adjuvant therapy, were entered into a Cox model to define the independent factors that predict the postoperative survival time. However, the histological subtype failed the proportional hazards assumption test (histological subtype * LN [T_] X2 = 7.208 P = 0.007), and the results observed for adjuvant therapy were inconsistent with this. Consequently, both of these variables were excluded from the Cox model. As a result, a total of five variables, namely age (as a categorical variable), modus operandi, tumor grade, ascites, and postoperative distant metastasis, were included in the Cox model. With multivariate analysis, modus operandi (i.e. R0 resection vs. R1 resection vs. R2 resection, P = 0.000, RR = 3.21 [95% confidence interval 1.90, 5.42], [Figure 1]), tumor grade (i.e. high grade vs. low grade, P = 0.006, RR = 2.70 [1.34, 5.45], [Figure 2]), ascites (i.e. Yes vs. No, P = 0.027, RR = 6.98 [1.24, 39.20], [Figure 3]), postoperative metastasis (i.e. Yes vs. No, P = 0.023, RR = 4.11 [1.22, 13.87], [Figure 4] and age (as a categorical variable) (i.e. ≥60 years old vs. <60 years old, P = 0.002, RR = 2.93 [1.47, 5.86], [Figure 5]) were all independent factors that significantly predicted the postoperative survival time [Table 2].

Bottom Line: The factors that were significantly associated with prognosis in the univariate analysis were age (as a categorical variable) (P = 0.006), modus operandi (P = 0.000), histologic subtype (P = 0.000), tumor grade (P = 0.000), ascites (P = 0.000), postoperative metastasis (P = 0.000) and adjuvant therapy (P = 0.030).However, in the multivariate analysis, the modus operandi (P = 0.000), tumor grade (P = 0.006), ascites (P = 0.027), postoperative metastasis (P = 0.023) and age (as a categorical variable) (P = 0.002) were the only significant predictors of survival.High grade, old age (≥ 60 years old), postoperative metastasis, and ascites predict poor prognoses.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

ABSTRACT

Background: Liposarcomas, which represent 20% of all adult sarcomas, are the most common histological type of malignant soft tissue tumors. The aim of this study was to define the prognostic factors that predict the postoperative survival period for patients with primary retroperitoneal liposarcoma.

Methods: The clinical data and prognoses of 71 patients with primary retroperitoneal liposarcoma who were treated in the General Hospital of the People's Liberation Army of China between January 1, 2000 and December 31, 2007 were retrospectively reviewed and analyzed.

Results: The primary tumor from each patient was resected; 54.9% (39/71) were deemed R0 resections, 31.0% (22/71) were R1 resections and 14.1% (10/71) were deemed R2 resections (palliative operations). The median follow up was 68 months (range: 1-160 months). Of the patients who received an R1 or R2 resection of their primary tumor, 96.7% (59/61) had tumor recurrence. The 1-year, 3-year, and 5-year recurrence-free rates were 77.0%, 29.8% and 19.7%, respectively. As of April 2013, 53 of the 71 patients had died from tumor recurrence. The overall 1-year, 3-year, 5-year, and 10-year survival rates were 88.7%, 76.1%, 61.7%, and 30.4%, respectively. The factors that were significantly associated with prognosis in the univariate analysis were age (as a categorical variable) (P = 0.006), modus operandi (P = 0.000), histologic subtype (P = 0.000), tumor grade (P = 0.000), ascites (P = 0.000), postoperative metastasis (P = 0.000) and adjuvant therapy (P = 0.030). However, in the multivariate analysis, the modus operandi (P = 0.000), tumor grade (P = 0.006), ascites (P = 0.027), postoperative metastasis (P = 0.023) and age (as a categorical variable) (P = 0.002) were the only significant predictors of survival.

Conclusions: Complete resection remains the most effective method for treating liposarcoma. High grade, old age (≥ 60 years old), postoperative metastasis, and ascites predict poor prognoses.

Show MeSH
Related in: MedlinePlus