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The survey of birth defects rate based on birth registration system.

Yu M, Ping Z, Zhang S, He Y, Dong R, Guo X - Chin. Med. J. (2015)

Bottom Line: The incidence of congenital heart disease (CHD) increased with time, particularly after 2012, it became the most frequent type (r s = 0.808, P < 0.001).Till then, the number of neural tube defects (NTDs) declined significantly (χ2 = 76.254, P < 0.01).NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of Health Ministry, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

ABSTRACT

Background: To investigate the surveillance trend of birth defects, incidence, distribution, occurrence regularity, and their relevant factors in Xi'an City in the last 10 years for proposing control measures.

Methods: The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003-2012. Microsoft Excel 2003 was used for data input, and Statistical Package for the Social Sciences version 16.0 (International Business Machines Corporation, New York, NY, USA) was used for descriptive analysis. χ2 test, Spearman correlation and linear-by-linear association trend test were used for statistical analyses.

Results: The birth defect rate declined from 9.18% in 2003 to 7.00% in 2012 (χ2 = 45.001, P < 0.01) with a mean value of 7.85%, which is below the Chinese national average level (χ2 = 20.451, P < 0.01). The order of five most common birth defects has changed. The incidence of congenital heart disease (CHD) increased with time, particularly after 2012, it became the most frequent type (r s = 0.808, P < 0.001). Till then, the number of neural tube defects (NTDs) declined significantly (χ2 = 76.254, P < 0.01). The average birth defects rate of 8.11% in rural areas was higher than that in urban areas (7.56%, χ2 = 7.919, P < 0.01) and much higher in males (8.28%) than that in females (7.18%, χ2 = 32.397, P < 0.01). Maternal age older than 35 years (χ2 = 35.298, P < 0.01) is the most dangerous age bracket of birth defects than maternal age younger than 20 years (χ2 = 7.128, P < 0.01).

Conclusions: A downward trend of birth defects was observed in Xi'an City from 2003 to 2012. NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

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Hierarchical cluster analysis of cumulative incidence of common birth defects in 13 counties and districts during 2003–2012.
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Figure 2: Hierarchical cluster analysis of cumulative incidence of common birth defects in 13 counties and districts during 2003–2012.

Mentions: Group 4: Consisted of Hu County and Zhouzhi County, and the rest of the districts and counties (Yanta District/Xincheng District/Lianhu District/Weiyang District/Lintong District/Changan District) are classified as Group 5 in which all kinds of deformity incidence are low [Figure 2].


The survey of birth defects rate based on birth registration system.

Yu M, Ping Z, Zhang S, He Y, Dong R, Guo X - Chin. Med. J. (2015)

Hierarchical cluster analysis of cumulative incidence of common birth defects in 13 counties and districts during 2003–2012.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837823&req=5

Figure 2: Hierarchical cluster analysis of cumulative incidence of common birth defects in 13 counties and districts during 2003–2012.
Mentions: Group 4: Consisted of Hu County and Zhouzhi County, and the rest of the districts and counties (Yanta District/Xincheng District/Lianhu District/Weiyang District/Lintong District/Changan District) are classified as Group 5 in which all kinds of deformity incidence are low [Figure 2].

Bottom Line: The incidence of congenital heart disease (CHD) increased with time, particularly after 2012, it became the most frequent type (r s = 0.808, P < 0.001).Till then, the number of neural tube defects (NTDs) declined significantly (χ2 = 76.254, P < 0.01).NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of Health Ministry, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

ABSTRACT

Background: To investigate the surveillance trend of birth defects, incidence, distribution, occurrence regularity, and their relevant factors in Xi'an City in the last 10 years for proposing control measures.

Methods: The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003-2012. Microsoft Excel 2003 was used for data input, and Statistical Package for the Social Sciences version 16.0 (International Business Machines Corporation, New York, NY, USA) was used for descriptive analysis. χ2 test, Spearman correlation and linear-by-linear association trend test were used for statistical analyses.

Results: The birth defect rate declined from 9.18% in 2003 to 7.00% in 2012 (χ2 = 45.001, P < 0.01) with a mean value of 7.85%, which is below the Chinese national average level (χ2 = 20.451, P < 0.01). The order of five most common birth defects has changed. The incidence of congenital heart disease (CHD) increased with time, particularly after 2012, it became the most frequent type (r s = 0.808, P < 0.001). Till then, the number of neural tube defects (NTDs) declined significantly (χ2 = 76.254, P < 0.01). The average birth defects rate of 8.11% in rural areas was higher than that in urban areas (7.56%, χ2 = 7.919, P < 0.01) and much higher in males (8.28%) than that in females (7.18%, χ2 = 32.397, P < 0.01). Maternal age older than 35 years (χ2 = 35.298, P < 0.01) is the most dangerous age bracket of birth defects than maternal age younger than 20 years (χ2 = 7.128, P < 0.01).

Conclusions: A downward trend of birth defects was observed in Xi'an City from 2003 to 2012. NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

Show MeSH
Related in: MedlinePlus