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Adult onset retinoblastoma: a case report.

Zhang X, Zheng L, Gao F, Dong F - Chin. Med. J. (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

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Adult retinoblastoma is rare, and diagnosis is usually made at a fairly advanced stage... He began to notice floaters in the left eye 1 year before, and was diagnosed with “glaucoma OS” in local hospital... Intraocular pressure (IOP) decreased from 36 mmHg to normal with topical IOP-lowering medication... The patient's visual acuity of the left eye began to decrease in October, 2012... He was diagnosed with “neovascular glaucoma OS” in local hospital, and was advised to have operation... During pre-operative examination, an intraocular mass was found... Fundus examination showed large, whitish, elevated mass lesions with vascular in the inferonasal quadrant of the retina [Figure 1b] and on the disk, with retinal seedings of whitish, nodular lesions [Figure 1c]... As malignant retinal tumor with vitreous seeding of the left eye was diagnosed, the patient was informed sufficiently and decided to receive enucleation... Characteristic manifestation of these adult retinoblastoma was whitish, elevated, vascularized retinal mass with vitreous seeding... In a few cases, the masses involved the whole eye... Diffuse retinoblastoma was also found... In the majority of cases, diagnosis were made at a fairly advanced stage... The majority of the reported retinoblastoma in adults were differentiated showing Flexner-Wintersteiner rosettes... Our patient's tumor was classified as undifferentiated retinoblastoma with no rosettes and fleurettes, so immunohistochemistry was needed for diagnosis.

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Slit-lamp examination showed plenty of small white floaters in the vitreous (a). Fundus examination showed large, whitish, elevated mass lesion in the inferonasal quadrant of the retina (b). Fundus examination showed whitish, elevated mass lesion with vascular on the disk, with retinal seedings of whitish, nodular lesions (c) B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions and absence of calcification (d).
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Figure 1: Slit-lamp examination showed plenty of small white floaters in the vitreous (a). Fundus examination showed large, whitish, elevated mass lesion in the inferonasal quadrant of the retina (b). Fundus examination showed whitish, elevated mass lesion with vascular on the disk, with retinal seedings of whitish, nodular lesions (c) B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions and absence of calcification (d).

Mentions: On presentation to PUMCH, best corrected visual acuity was 1.2/Jr4 OD and 0.5/Jr7 OS. IOP was 18 mmHg OD and 42 mmHg OS. In the left eye, there were anterior chamber cells, neovascular of the pupil margin, and plenty of small white floaters in the vitreous [Figure 1a]. Fundus examination showed large, whitish, elevated mass lesions with vascular in the inferonasal quadrant of the retina [Figure 1b] and on the disk, with retinal seedings of whitish, nodular lesions [Figure 1c]. B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions with moderate reflective echoes and absence of calcification [Figure 1d]. Systemic examinations including blood and urine tests, electrocardiogram, chest computed tomography, abdomen B-scan ultrasonography, as well as 99mTc-methylene diphosphonate whole body bone imaging were normal.


Adult onset retinoblastoma: a case report.

Zhang X, Zheng L, Gao F, Dong F - Chin. Med. J. (2015)

Slit-lamp examination showed plenty of small white floaters in the vitreous (a). Fundus examination showed large, whitish, elevated mass lesion in the inferonasal quadrant of the retina (b). Fundus examination showed whitish, elevated mass lesion with vascular on the disk, with retinal seedings of whitish, nodular lesions (c) B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions and absence of calcification (d).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837810&req=5

Figure 1: Slit-lamp examination showed plenty of small white floaters in the vitreous (a). Fundus examination showed large, whitish, elevated mass lesion in the inferonasal quadrant of the retina (b). Fundus examination showed whitish, elevated mass lesion with vascular on the disk, with retinal seedings of whitish, nodular lesions (c) B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions and absence of calcification (d).
Mentions: On presentation to PUMCH, best corrected visual acuity was 1.2/Jr4 OD and 0.5/Jr7 OS. IOP was 18 mmHg OD and 42 mmHg OS. In the left eye, there were anterior chamber cells, neovascular of the pupil margin, and plenty of small white floaters in the vitreous [Figure 1a]. Fundus examination showed large, whitish, elevated mass lesions with vascular in the inferonasal quadrant of the retina [Figure 1b] and on the disk, with retinal seedings of whitish, nodular lesions [Figure 1c]. B-scan ultrasonography showed vitreous opacities and intraocular elevated lesions with moderate reflective echoes and absence of calcification [Figure 1d]. Systemic examinations including blood and urine tests, electrocardiogram, chest computed tomography, abdomen B-scan ultrasonography, as well as 99mTc-methylene diphosphonate whole body bone imaging were normal.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Adult retinoblastoma is rare, and diagnosis is usually made at a fairly advanced stage... He began to notice floaters in the left eye 1 year before, and was diagnosed with “glaucoma OS” in local hospital... Intraocular pressure (IOP) decreased from 36 mmHg to normal with topical IOP-lowering medication... The patient's visual acuity of the left eye began to decrease in October, 2012... He was diagnosed with “neovascular glaucoma OS” in local hospital, and was advised to have operation... During pre-operative examination, an intraocular mass was found... Fundus examination showed large, whitish, elevated mass lesions with vascular in the inferonasal quadrant of the retina [Figure 1b] and on the disk, with retinal seedings of whitish, nodular lesions [Figure 1c]... As malignant retinal tumor with vitreous seeding of the left eye was diagnosed, the patient was informed sufficiently and decided to receive enucleation... Characteristic manifestation of these adult retinoblastoma was whitish, elevated, vascularized retinal mass with vitreous seeding... In a few cases, the masses involved the whole eye... Diffuse retinoblastoma was also found... In the majority of cases, diagnosis were made at a fairly advanced stage... The majority of the reported retinoblastoma in adults were differentiated showing Flexner-Wintersteiner rosettes... Our patient's tumor was classified as undifferentiated retinoblastoma with no rosettes and fleurettes, so immunohistochemistry was needed for diagnosis.

Show MeSH
Related in: MedlinePlus