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Prognostic significance of tumor-infiltrating CD8⁺ or CD3⁺ T lymphocytes and interleukin-2 expression in radically resected non-small cell lung cancer.

Tian C, Lu S, Fan Q, Zhang W, Jiao S, Zhao X, Wu Z, Sun L, Wang L - Chin. Med. J. (2015)

Bottom Line: Altered immunoresponse is associated with tumorigenesis and cancer progression.Clinicopathological and survival data were collected and analyzed using the Chi-squared test, Kaplan-Meier curves, and the log-rank test or the Cox regression model.In addition, the levels of CD8 + T lymphocytes were associated with an unfavorable 5-year OS, whereas patients with high levels of CD3 + T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.

ABSTRACT

Background: Altered immunoresponse is associated with tumorigenesis and cancer progression. This study assessed the levels of tumor-infiltrating CD3 + or CD8 + T lymphocytes and interleukin-2 (IL-2) protein in radically resected non-small cell lung cancer (NSCLC) tissues to predict overall survival (OS) of the patients.

Methods: Paraffin-embedded tissue specimens from 129 NSCLC patients were retrospectively collected for immunostaining of CD8 + , CD3 + , and IL-2 expression. Clinicopathological and survival data were collected and analyzed using the Chi-squared test, Kaplan-Meier curves, and the log-rank test or the Cox regression model.

Results: The data showed a significant inverse association between CD8 + T lymphocyte levels and IL-2 expression (r = -0.927; P = 0.000) and between the levels of CD8 + and CD3 + T lymphocytes (r = -0.722; P = 0.000), but a positive association between CD3 + T lymphocyte levels and IL-2 expression (r = 0.781; P = 0.000) in NSCLC tissues. Furthermore, the levels of CD3 + and CD8 + T lymphocytes and IL-2 expression were associated with tumor stage (P = 0.023, 0.006, and 0.031, respectively) and the level of CD8 + T lymphocytes was associated with the patient gender (P = 0.024). In addition, the levels of CD8 + T lymphocytes were associated with an unfavorable 5-year OS, whereas patients with high levels of CD3 + T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.

Conclusions: The levels of CD8 + T cells in tumor lesions and IL-2 expression were both independent predictors of OS for these NSCLC patients. Thus, the detection of tumor-infiltrating CD3 + or CD8 + T lymphocytes and IL-2 expression could be useful to predict the prognosis of radically resected NSCLC patients.

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Kaplan–Meier analysis of OS of non-small cell lung cancer patients according to the level of infiltration of CD3+ T cells (a) and CD8+ T cells (b) as well as interleukin-2 expression (c).
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Figure 2: Kaplan–Meier analysis of OS of non-small cell lung cancer patients according to the level of infiltration of CD3+ T cells (a) and CD8+ T cells (b) as well as interleukin-2 expression (c).

Mentions: Furthermore, the number of CD8+ T cells in the tumor lesion appeared to be an unfavorable prognostic factor (5-year OS of 21.1% vs. 48.6% for high vs. low levels; P = 0.000, Table 2 and Figure 2b); Table 2 and Figure 2b Patients with high levels of CD3+ T cells in the tumor lesions had a significantly better 5-year OS than patients with low levels of CD3+ T cells in the tumor lesions (55.3% vs. 25.6%; P = 0.002; Table 2 and Figure 2a). Similarly, patients with IL-2-expressing tumors had a better 5-year OS rate than those patients with a low IL-2-expressing tumor (47.5% vs. 18.4%; P = 0.000; Table 2 and Figure 2c).


Prognostic significance of tumor-infiltrating CD8⁺ or CD3⁺ T lymphocytes and interleukin-2 expression in radically resected non-small cell lung cancer.

Tian C, Lu S, Fan Q, Zhang W, Jiao S, Zhao X, Wu Z, Sun L, Wang L - Chin. Med. J. (2015)

Kaplan–Meier analysis of OS of non-small cell lung cancer patients according to the level of infiltration of CD3+ T cells (a) and CD8+ T cells (b) as well as interleukin-2 expression (c).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837804&req=5

Figure 2: Kaplan–Meier analysis of OS of non-small cell lung cancer patients according to the level of infiltration of CD3+ T cells (a) and CD8+ T cells (b) as well as interleukin-2 expression (c).
Mentions: Furthermore, the number of CD8+ T cells in the tumor lesion appeared to be an unfavorable prognostic factor (5-year OS of 21.1% vs. 48.6% for high vs. low levels; P = 0.000, Table 2 and Figure 2b); Table 2 and Figure 2b Patients with high levels of CD3+ T cells in the tumor lesions had a significantly better 5-year OS than patients with low levels of CD3+ T cells in the tumor lesions (55.3% vs. 25.6%; P = 0.002; Table 2 and Figure 2a). Similarly, patients with IL-2-expressing tumors had a better 5-year OS rate than those patients with a low IL-2-expressing tumor (47.5% vs. 18.4%; P = 0.000; Table 2 and Figure 2c).

Bottom Line: Altered immunoresponse is associated with tumorigenesis and cancer progression.Clinicopathological and survival data were collected and analyzed using the Chi-squared test, Kaplan-Meier curves, and the log-rank test or the Cox regression model.In addition, the levels of CD8 + T lymphocytes were associated with an unfavorable 5-year OS, whereas patients with high levels of CD3 + T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.

ABSTRACT

Background: Altered immunoresponse is associated with tumorigenesis and cancer progression. This study assessed the levels of tumor-infiltrating CD3 + or CD8 + T lymphocytes and interleukin-2 (IL-2) protein in radically resected non-small cell lung cancer (NSCLC) tissues to predict overall survival (OS) of the patients.

Methods: Paraffin-embedded tissue specimens from 129 NSCLC patients were retrospectively collected for immunostaining of CD8 + , CD3 + , and IL-2 expression. Clinicopathological and survival data were collected and analyzed using the Chi-squared test, Kaplan-Meier curves, and the log-rank test or the Cox regression model.

Results: The data showed a significant inverse association between CD8 + T lymphocyte levels and IL-2 expression (r = -0.927; P = 0.000) and between the levels of CD8 + and CD3 + T lymphocytes (r = -0.722; P = 0.000), but a positive association between CD3 + T lymphocyte levels and IL-2 expression (r = 0.781; P = 0.000) in NSCLC tissues. Furthermore, the levels of CD3 + and CD8 + T lymphocytes and IL-2 expression were associated with tumor stage (P = 0.023, 0.006, and 0.031, respectively) and the level of CD8 + T lymphocytes was associated with the patient gender (P = 0.024). In addition, the levels of CD8 + T lymphocytes were associated with an unfavorable 5-year OS, whereas patients with high levels of CD3 + T lymphocytes in tumor lesions and IL-2-expressing tumors had significantly better 5-year OS rates than patients with low levels.

Conclusions: The levels of CD8 + T cells in tumor lesions and IL-2 expression were both independent predictors of OS for these NSCLC patients. Thus, the detection of tumor-infiltrating CD3 + or CD8 + T lymphocytes and IL-2 expression could be useful to predict the prognosis of radically resected NSCLC patients.

Show MeSH
Related in: MedlinePlus