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Shifts in retinal vessel diameter and oxygen saturation in Chinese type 2 diabetes mellitus patients.

Dong Y, Lin L, Yan H, Fu Y, Zong Y, Yuan Y, Huang X, Li Y, He H, Gao Q - BMC Ophthalmol (2016)

Bottom Line: The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively.Both the NPDR and PDR groups showed significantly smaller AVR than the control.Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001).

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S Xianlie Road, Guangzhou, 510060, China.

ABSTRACT

Background: The aim of this study was to analyze the shifts in retinal vessel diameter and oxygen saturation in diabetic patients with and without diabetic retinopathy (DR), as well as to assess the association between diabetes duration and either vessel diameter or oxygen saturation.

Methods: In total, 99 Type 2 DM patients were recruited for the study and were divided into three groups: DM with non-obvious retinopathy (DM, n = 29), non-proliferative diabetic retinopathy (NPDR, n = 40), and proliferative diabetic retinopathy (PDR, n = 30). In addition, 78 age-matched healthy individuals were chosen as the control. The diameter and oxygen saturation of the retinal vessels were analyzed using a noninvasive retinal oximeter, and then compared between the three groups and the normal control. Association analysis was applied to analyze the possible influencing factors, including the diameter and oxygen saturation of retinal vessels, on best corrected visual acuity BCVA, as well as the relationship between diabetes duration and the oximetry values.

Results: All of the diabetic patients showed thinner arterioles, wider venules, and a smaller arteriolar-to-venular ratio (AVR) than the healthy individuals. The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively. Both the NPDR and PDR groups showed significantly smaller AVR than the control. All of the diabetic patients exhibited higher retinal vessel oxygen saturation than the healthy individuals. Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001). An increased diabetes duration was associated with decreased arteriolar diameter (slope = -0.082 pixels/year, r (2) = 0.085, P = 0.004) and AVR (slope = -0.009/year, r (2) = 0.349, P < 0.001), and with increased venular diameter (slope = 0.104 pixels/year, r (2) = -0.109, P = 0.001).

Conclusions: In this Chinese population with type 2 DM, the thinner arterioles and wider venules point to microvascular dysfunction in DR. The increased oxygen saturation of the retinal vessels suggests that retinal oxygen metabolism is affected in diabetic retinopathy.

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Related in: MedlinePlus

The oxygen saturation of arterioles, venules and AV-difference in the four groups studied. Both arteriolar and venular oxygen saturation showed increasing trend with increasing severity of disease (**p < 0.01)
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Fig3: The oxygen saturation of arterioles, venules and AV-difference in the four groups studied. Both arteriolar and venular oxygen saturation showed increasing trend with increasing severity of disease (**p < 0.01)

Mentions: The retinal oxygen saturation in healthy individuals was 95.0 ± 4.78 % in the arterioles and 58.50 ± 3.76 % in the venules. Compared with the normal control group, all of the diabetes patients showed higher oxygen saturation in both the arterioles and venules. Further, the differences between the NPDR or PDR patients and the normal controls were both statistically significant (p < 0.01; Fig. 3). Additionally, there was an obvious increasing trend in either arteriolar or venular oxygen saturation with the increasing severity of disease, although significance was only reached for the comparison of controls to the NPDR and PDR groups.Fig. 3


Shifts in retinal vessel diameter and oxygen saturation in Chinese type 2 diabetes mellitus patients.

Dong Y, Lin L, Yan H, Fu Y, Zong Y, Yuan Y, Huang X, Li Y, He H, Gao Q - BMC Ophthalmol (2016)

The oxygen saturation of arterioles, venules and AV-difference in the four groups studied. Both arteriolar and venular oxygen saturation showed increasing trend with increasing severity of disease (**p < 0.01)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837630&req=5

Fig3: The oxygen saturation of arterioles, venules and AV-difference in the four groups studied. Both arteriolar and venular oxygen saturation showed increasing trend with increasing severity of disease (**p < 0.01)
Mentions: The retinal oxygen saturation in healthy individuals was 95.0 ± 4.78 % in the arterioles and 58.50 ± 3.76 % in the venules. Compared with the normal control group, all of the diabetes patients showed higher oxygen saturation in both the arterioles and venules. Further, the differences between the NPDR or PDR patients and the normal controls were both statistically significant (p < 0.01; Fig. 3). Additionally, there was an obvious increasing trend in either arteriolar or venular oxygen saturation with the increasing severity of disease, although significance was only reached for the comparison of controls to the NPDR and PDR groups.Fig. 3

Bottom Line: The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively.Both the NPDR and PDR groups showed significantly smaller AVR than the control.Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001).

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S Xianlie Road, Guangzhou, 510060, China.

ABSTRACT

Background: The aim of this study was to analyze the shifts in retinal vessel diameter and oxygen saturation in diabetic patients with and without diabetic retinopathy (DR), as well as to assess the association between diabetes duration and either vessel diameter or oxygen saturation.

Methods: In total, 99 Type 2 DM patients were recruited for the study and were divided into three groups: DM with non-obvious retinopathy (DM, n = 29), non-proliferative diabetic retinopathy (NPDR, n = 40), and proliferative diabetic retinopathy (PDR, n = 30). In addition, 78 age-matched healthy individuals were chosen as the control. The diameter and oxygen saturation of the retinal vessels were analyzed using a noninvasive retinal oximeter, and then compared between the three groups and the normal control. Association analysis was applied to analyze the possible influencing factors, including the diameter and oxygen saturation of retinal vessels, on best corrected visual acuity BCVA, as well as the relationship between diabetes duration and the oximetry values.

Results: All of the diabetic patients showed thinner arterioles, wider venules, and a smaller arteriolar-to-venular ratio (AVR) than the healthy individuals. The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively. Both the NPDR and PDR groups showed significantly smaller AVR than the control. All of the diabetic patients exhibited higher retinal vessel oxygen saturation than the healthy individuals. Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001). An increased diabetes duration was associated with decreased arteriolar diameter (slope = -0.082 pixels/year, r (2) = 0.085, P = 0.004) and AVR (slope = -0.009/year, r (2) = 0.349, P < 0.001), and with increased venular diameter (slope = 0.104 pixels/year, r (2) = -0.109, P = 0.001).

Conclusions: In this Chinese population with type 2 DM, the thinner arterioles and wider venules point to microvascular dysfunction in DR. The increased oxygen saturation of the retinal vessels suggests that retinal oxygen metabolism is affected in diabetic retinopathy.

Show MeSH
Related in: MedlinePlus