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Shifts in retinal vessel diameter and oxygen saturation in Chinese type 2 diabetes mellitus patients.

Dong Y, Lin L, Yan H, Fu Y, Zong Y, Yuan Y, Huang X, Li Y, He H, Gao Q - BMC Ophthalmol (2016)

Bottom Line: The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively.Both the NPDR and PDR groups showed significantly smaller AVR than the control.Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001).

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S Xianlie Road, Guangzhou, 510060, China.

ABSTRACT

Background: The aim of this study was to analyze the shifts in retinal vessel diameter and oxygen saturation in diabetic patients with and without diabetic retinopathy (DR), as well as to assess the association between diabetes duration and either vessel diameter or oxygen saturation.

Methods: In total, 99 Type 2 DM patients were recruited for the study and were divided into three groups: DM with non-obvious retinopathy (DM, n = 29), non-proliferative diabetic retinopathy (NPDR, n = 40), and proliferative diabetic retinopathy (PDR, n = 30). In addition, 78 age-matched healthy individuals were chosen as the control. The diameter and oxygen saturation of the retinal vessels were analyzed using a noninvasive retinal oximeter, and then compared between the three groups and the normal control. Association analysis was applied to analyze the possible influencing factors, including the diameter and oxygen saturation of retinal vessels, on best corrected visual acuity BCVA, as well as the relationship between diabetes duration and the oximetry values.

Results: All of the diabetic patients showed thinner arterioles, wider venules, and a smaller arteriolar-to-venular ratio (AVR) than the healthy individuals. The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively. Both the NPDR and PDR groups showed significantly smaller AVR than the control. All of the diabetic patients exhibited higher retinal vessel oxygen saturation than the healthy individuals. Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001). An increased diabetes duration was associated with decreased arteriolar diameter (slope = -0.082 pixels/year, r (2) = 0.085, P = 0.004) and AVR (slope = -0.009/year, r (2) = 0.349, P < 0.001), and with increased venular diameter (slope = 0.104 pixels/year, r (2) = -0.109, P = 0.001).

Conclusions: In this Chinese population with type 2 DM, the thinner arterioles and wider venules point to microvascular dysfunction in DR. The increased oxygen saturation of the retinal vessels suggests that retinal oxygen metabolism is affected in diabetic retinopathy.

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Related in: MedlinePlus

The diameter of retinal arterioles and venules, AVR in the four groups studied. All diabetic patients showed thinner arterioles, wider venules, and smaller AVR compared with normal control, which varied with severity from DM with no DR to PDR. (**p < 0.01, *p < 0.05)
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Fig2: The diameter of retinal arterioles and venules, AVR in the four groups studied. All diabetic patients showed thinner arterioles, wider venules, and smaller AVR compared with normal control, which varied with severity from DM with no DR to PDR. (**p < 0.01, *p < 0.05)

Mentions: In healthy individuals, the diameters of the arterioles and venules were13.47 ± 1.19 pixels, and 16.80 ± 1.68 pixels, respectively, and the AVR was 0.81 ± 0.07. All diabetic patients showed thinner arterioles and wider venules and, therefore, smaller AVR than the healthy individuals, which changed according to the severity of the disease. Only the PDR group exhibited statistically significant thinner arterioles and wider venules when compared with the normal group. However, both the NPDR and PDR patients had significantly smaller AVR than the controls (p < 0.01; Fig. 2).Fig. 2


Shifts in retinal vessel diameter and oxygen saturation in Chinese type 2 diabetes mellitus patients.

Dong Y, Lin L, Yan H, Fu Y, Zong Y, Yuan Y, Huang X, Li Y, He H, Gao Q - BMC Ophthalmol (2016)

The diameter of retinal arterioles and venules, AVR in the four groups studied. All diabetic patients showed thinner arterioles, wider venules, and smaller AVR compared with normal control, which varied with severity from DM with no DR to PDR. (**p < 0.01, *p < 0.05)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837630&req=5

Fig2: The diameter of retinal arterioles and venules, AVR in the four groups studied. All diabetic patients showed thinner arterioles, wider venules, and smaller AVR compared with normal control, which varied with severity from DM with no DR to PDR. (**p < 0.01, *p < 0.05)
Mentions: In healthy individuals, the diameters of the arterioles and venules were13.47 ± 1.19 pixels, and 16.80 ± 1.68 pixels, respectively, and the AVR was 0.81 ± 0.07. All diabetic patients showed thinner arterioles and wider venules and, therefore, smaller AVR than the healthy individuals, which changed according to the severity of the disease. Only the PDR group exhibited statistically significant thinner arterioles and wider venules when compared with the normal group. However, both the NPDR and PDR patients had significantly smaller AVR than the controls (p < 0.01; Fig. 2).Fig. 2

Bottom Line: The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively.Both the NPDR and PDR groups showed significantly smaller AVR than the control.Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001).

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S Xianlie Road, Guangzhou, 510060, China.

ABSTRACT

Background: The aim of this study was to analyze the shifts in retinal vessel diameter and oxygen saturation in diabetic patients with and without diabetic retinopathy (DR), as well as to assess the association between diabetes duration and either vessel diameter or oxygen saturation.

Methods: In total, 99 Type 2 DM patients were recruited for the study and were divided into three groups: DM with non-obvious retinopathy (DM, n = 29), non-proliferative diabetic retinopathy (NPDR, n = 40), and proliferative diabetic retinopathy (PDR, n = 30). In addition, 78 age-matched healthy individuals were chosen as the control. The diameter and oxygen saturation of the retinal vessels were analyzed using a noninvasive retinal oximeter, and then compared between the three groups and the normal control. Association analysis was applied to analyze the possible influencing factors, including the diameter and oxygen saturation of retinal vessels, on best corrected visual acuity BCVA, as well as the relationship between diabetes duration and the oximetry values.

Results: All of the diabetic patients showed thinner arterioles, wider venules, and a smaller arteriolar-to-venular ratio (AVR) than the healthy individuals. The AVR results from the controls through to the PDR group were 0.81 ± 0.07, 0.78 ± 0.07, 0.76 ± 0.07 and 0.67 ± 0.07, respectively. Both the NPDR and PDR groups showed significantly smaller AVR than the control. All of the diabetic patients exhibited higher retinal vessel oxygen saturation than the healthy individuals. Among all of the oximetry values, AVR exhibited the most significant correlation with best corrected visual acuity (BCVA) (β = 1.533, P < 0.0001). An increased diabetes duration was associated with decreased arteriolar diameter (slope = -0.082 pixels/year, r (2) = 0.085, P = 0.004) and AVR (slope = -0.009/year, r (2) = 0.349, P < 0.001), and with increased venular diameter (slope = 0.104 pixels/year, r (2) = -0.109, P = 0.001).

Conclusions: In this Chinese population with type 2 DM, the thinner arterioles and wider venules point to microvascular dysfunction in DR. The increased oxygen saturation of the retinal vessels suggests that retinal oxygen metabolism is affected in diabetic retinopathy.

Show MeSH
Related in: MedlinePlus