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Age of asthma onset and vulnerability to ambient air pollution: an observational population-based study of adults from Southern Taiwan.

Wu TJ, Wu CF, Chen BY, Lee YL, Guo YL - BMC Pulm Med (2016)

Bottom Line: Data from 23,551 participants remained satisfactory with a response rate of 66 %.Among 20,508 participants aged 26-50 years, 703 questionnaire-determined asthmatics were identified and included for analysis.In adulthood, exposure to PM10 has a greater effect on late-onset asthma than early-onset asthma and deserves greater attention among ambient air pollutants.

View Article: PubMed Central - PubMed

Affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, 17, Syujhou Road, Taipei, 100, Taiwan.

ABSTRACT

Background: Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset and early-onset asthma. However, there is little known about the association of onset-age phenotype and air pollution. In this population-based study, we aimed to determine the association of asthma severity outcomes and air pollution regarding age at onset of asthma.

Methods: In 2004, we conducted a cross-sectional questionnaire survey about respiratory health among schoolchildren's parents randomly selected from 94 of 816 elementary and middle schools in southern Taiwan. Participants ever having typical asthma symptoms were enrolled. We used kriging method to estimate individual exposure to ambient air pollution in the preceding year before the year of asthma severity survey. Ordered logistic regression was used to determine the association of exposure and asthma severity scores. Age at asthma onset of 12 years was used as a cut-off to define early- or late-onset asthma.

Results: The study surveyed 35,682 participants. Data from 23,551 participants remained satisfactory with a response rate of 66 %. Among 20,508 participants aged 26-50 years, 703 questionnaire-determined asthmatics were identified and included for analysis. Using the median of PM10 (66 μg/m(3)) as a cut-off, those exposed to higher PM10 were more likely to have higher severity scores (OR = 1.74; 95 % CI, 1.13 - 2.70) only for asthmatics with asthma onset at > 12 years.

Conclusions: In adulthood, exposure to PM10 has a greater effect on late-onset asthma than early-onset asthma and deserves greater attention among ambient air pollutants.

No MeSH data available.


Related in: MedlinePlus

Plots of measured values and predicted values of PM10 (a), NO2 (b), SO2 (c), and CO (d) at air monitoring stations in 2003 by the kriging method. Regression lines and identity lines are shown in red and blue, respectively
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Fig3: Plots of measured values and predicted values of PM10 (a), NO2 (b), SO2 (c), and CO (d) at air monitoring stations in 2003 by the kriging method. Regression lines and identity lines are shown in red and blue, respectively

Mentions: The interquartile range was 61.0 to 71.0 μg/m3 for PM10, 16.9 to 23.6 ppb for NO2, 3.8 to 7.4 ppb for SO2, and 0.55 to 0.71 ppm for CO, respectively. The correlation of air pollutant values was relatively high with each other (R > 0.80) (Additional file 1: Table S2). The ratios of the geometric means of predicted air pollutant values over measured ones were 1.03 for PM10, 1.11 for NO2, 1.18 for SO2, 1.03 for CO in 2003, 1.02 for PM10, 1.10 for NO2, 1.17 for SO2, 1.03 for CO in 2002, respectively. The correlation coefficients of predicted and measured air pollutant values were 0.58 for PM10, 0.86 for NO2, 0.79 for SO2, 0.73 for CO in 2003, respectively (Fig. 3). Similarly, the correlation coefficients of predicted and measured air pollutant levels were 0.55 for PM10, 0.90 for NO2, 0.80 for SO2, 0.65 for CO in 2002, respectively. The result showed that the predicting model is a reasonable model for PM10, NO2, SO2 and CO. However, the correlation coefficients of predicted O3 and measured O3 were not high (R < 0.28). Therefore, O3 was not included in subsequent analyses.Fig. 3


Age of asthma onset and vulnerability to ambient air pollution: an observational population-based study of adults from Southern Taiwan.

Wu TJ, Wu CF, Chen BY, Lee YL, Guo YL - BMC Pulm Med (2016)

Plots of measured values and predicted values of PM10 (a), NO2 (b), SO2 (c), and CO (d) at air monitoring stations in 2003 by the kriging method. Regression lines and identity lines are shown in red and blue, respectively
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837625&req=5

Fig3: Plots of measured values and predicted values of PM10 (a), NO2 (b), SO2 (c), and CO (d) at air monitoring stations in 2003 by the kriging method. Regression lines and identity lines are shown in red and blue, respectively
Mentions: The interquartile range was 61.0 to 71.0 μg/m3 for PM10, 16.9 to 23.6 ppb for NO2, 3.8 to 7.4 ppb for SO2, and 0.55 to 0.71 ppm for CO, respectively. The correlation of air pollutant values was relatively high with each other (R > 0.80) (Additional file 1: Table S2). The ratios of the geometric means of predicted air pollutant values over measured ones were 1.03 for PM10, 1.11 for NO2, 1.18 for SO2, 1.03 for CO in 2003, 1.02 for PM10, 1.10 for NO2, 1.17 for SO2, 1.03 for CO in 2002, respectively. The correlation coefficients of predicted and measured air pollutant values were 0.58 for PM10, 0.86 for NO2, 0.79 for SO2, 0.73 for CO in 2003, respectively (Fig. 3). Similarly, the correlation coefficients of predicted and measured air pollutant levels were 0.55 for PM10, 0.90 for NO2, 0.80 for SO2, 0.65 for CO in 2002, respectively. The result showed that the predicting model is a reasonable model for PM10, NO2, SO2 and CO. However, the correlation coefficients of predicted O3 and measured O3 were not high (R < 0.28). Therefore, O3 was not included in subsequent analyses.Fig. 3

Bottom Line: Data from 23,551 participants remained satisfactory with a response rate of 66 %.Among 20,508 participants aged 26-50 years, 703 questionnaire-determined asthmatics were identified and included for analysis.In adulthood, exposure to PM10 has a greater effect on late-onset asthma than early-onset asthma and deserves greater attention among ambient air pollutants.

View Article: PubMed Central - PubMed

Affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, 17, Syujhou Road, Taipei, 100, Taiwan.

ABSTRACT

Background: Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset and early-onset asthma. However, there is little known about the association of onset-age phenotype and air pollution. In this population-based study, we aimed to determine the association of asthma severity outcomes and air pollution regarding age at onset of asthma.

Methods: In 2004, we conducted a cross-sectional questionnaire survey about respiratory health among schoolchildren's parents randomly selected from 94 of 816 elementary and middle schools in southern Taiwan. Participants ever having typical asthma symptoms were enrolled. We used kriging method to estimate individual exposure to ambient air pollution in the preceding year before the year of asthma severity survey. Ordered logistic regression was used to determine the association of exposure and asthma severity scores. Age at asthma onset of 12 years was used as a cut-off to define early- or late-onset asthma.

Results: The study surveyed 35,682 participants. Data from 23,551 participants remained satisfactory with a response rate of 66 %. Among 20,508 participants aged 26-50 years, 703 questionnaire-determined asthmatics were identified and included for analysis. Using the median of PM10 (66 μg/m(3)) as a cut-off, those exposed to higher PM10 were more likely to have higher severity scores (OR = 1.74; 95 % CI, 1.13 - 2.70) only for asthmatics with asthma onset at > 12 years.

Conclusions: In adulthood, exposure to PM10 has a greater effect on late-onset asthma than early-onset asthma and deserves greater attention among ambient air pollutants.

No MeSH data available.


Related in: MedlinePlus