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Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma.

Marmarelis ME, Davis MR, Sethi NS, Krajewksi KM, McKay RR, Choueiri TK, Ott PA - J Immunother Cancer (2016)

Bottom Line: Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC).Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology.This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA USA.

ABSTRACT
Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC). Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology. This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.

No MeSH data available.


Related in: MedlinePlus

a PET CT images of the mediastinal mass, pulmonary lesion and renal mass. Left column: Pre- pembrolizumab; right column: 8 weeks after administration of one dose of pembrolizumab. There is near complete involution of the anterior mediastinal mass and a decrease in size of the pulmonary lesion. The size of the renal mass is unchanged. b Size (cm) on axial imaging (CT or PET/CT) of renal, mediastinal and dominant right pulmonary nodule over time. The last scan showed two new subcentimter pulmonary metastases and increased size of a soft tissue component of the left renal mass
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Fig4: a PET CT images of the mediastinal mass, pulmonary lesion and renal mass. Left column: Pre- pembrolizumab; right column: 8 weeks after administration of one dose of pembrolizumab. There is near complete involution of the anterior mediastinal mass and a decrease in size of the pulmonary lesion. The size of the renal mass is unchanged. b Size (cm) on axial imaging (CT or PET/CT) of renal, mediastinal and dominant right pulmonary nodule over time. The last scan showed two new subcentimter pulmonary metastases and increased size of a soft tissue component of the left renal mass

Mentions: Restaging CTs of the chest, abdomen, and pelvis performed in September 2014 demonstrated dramatic reduction in size of several lung metastases, while others remained stable. The right adrenal lesion, several mesenteric nodules, and a subcutaneous nodule on the left anterior abdominal wall were all substantially smaller in size. The left renal mass remained stable. Serial CTs of the chest, abdomen, and pelvis in November 2014, February 2015, May 2015, and August 2014 showed continued decrease in tumor size consistent with a partial response to treatment for a duration of 14 months (Fig. 4). Most recently, a chest, abdomen, and pelvic CT in November of 2015 showed two new subcentimeter pulmonary lesions and a satellite nodule in the primary renal cell cancer. The patient is currently undergoing re-induction therapy with pembrolizumab.Fig. 4


Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma.

Marmarelis ME, Davis MR, Sethi NS, Krajewksi KM, McKay RR, Choueiri TK, Ott PA - J Immunother Cancer (2016)

a PET CT images of the mediastinal mass, pulmonary lesion and renal mass. Left column: Pre- pembrolizumab; right column: 8 weeks after administration of one dose of pembrolizumab. There is near complete involution of the anterior mediastinal mass and a decrease in size of the pulmonary lesion. The size of the renal mass is unchanged. b Size (cm) on axial imaging (CT or PET/CT) of renal, mediastinal and dominant right pulmonary nodule over time. The last scan showed two new subcentimter pulmonary metastases and increased size of a soft tissue component of the left renal mass
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837591&req=5

Fig4: a PET CT images of the mediastinal mass, pulmonary lesion and renal mass. Left column: Pre- pembrolizumab; right column: 8 weeks after administration of one dose of pembrolizumab. There is near complete involution of the anterior mediastinal mass and a decrease in size of the pulmonary lesion. The size of the renal mass is unchanged. b Size (cm) on axial imaging (CT or PET/CT) of renal, mediastinal and dominant right pulmonary nodule over time. The last scan showed two new subcentimter pulmonary metastases and increased size of a soft tissue component of the left renal mass
Mentions: Restaging CTs of the chest, abdomen, and pelvis performed in September 2014 demonstrated dramatic reduction in size of several lung metastases, while others remained stable. The right adrenal lesion, several mesenteric nodules, and a subcutaneous nodule on the left anterior abdominal wall were all substantially smaller in size. The left renal mass remained stable. Serial CTs of the chest, abdomen, and pelvis in November 2014, February 2015, May 2015, and August 2014 showed continued decrease in tumor size consistent with a partial response to treatment for a duration of 14 months (Fig. 4). Most recently, a chest, abdomen, and pelvic CT in November of 2015 showed two new subcentimeter pulmonary lesions and a satellite nodule in the primary renal cell cancer. The patient is currently undergoing re-induction therapy with pembrolizumab.Fig. 4

Bottom Line: Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC).Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology.This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA USA.

ABSTRACT
Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC). Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology. This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.

No MeSH data available.


Related in: MedlinePlus