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MicroRNAs: The Role in Autoimmune Inflammation.

Baulina NM, Kulakova OG, Favorova OO - Acta Naturae (2016 Jan-Mar)

Bottom Line: MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators.This review summarizes the data on biogenesis and the mechanisms of miRNA action.Currently, a lot of research is focused on this problem.

View Article: PubMed Central - PubMed

Affiliation: Pirogov Russian National Research Medical University, Ostrovityanova St., 1, Moscow, 117997, Russia ; Russian Cardiology Research and Production Complex, 3-rd Cherepkovskay St., 15a, Moscow, 121552 , Russia.

ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3'-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, through a complex regulatory network, the expression of more than 60% of human genes. MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators. Disruption of this regulation may lead to the development of various pathological conditions, including autoimmune inflammation. This review summarizes the data on biogenesis and the mechanisms of miRNA action. We discuss the role of miRNAs in the development and the action of the immune system, as well as in the development of an autoimmune inflammatory response. Special attention is given to the role of miRNAs in the autoimmune inflammation in multiple sclerosis, which is a serious socially significant disease of the central nervous system. Currently, a lot of research is focused on this problem.

No MeSH data available.


Related in: MedlinePlus

Redundancy and pleiotropy of the miRNA regulatory system. The STAT3 gene (green oval)encodes a transcriptional factor. Red ovals are miRNAs downregulating the STAT3 geneexpression. Each of the miRNAs inhibits expression of other target mRNAs (blue, violet,and light blue ovals). Additional miRNAs that may affect the STAT3 gene expression arelisted on the right-hand side. The regulatory network was simulated using theMirtarbase database (http://mirtarbase.mbc.nctu.edu.tw/index.php).
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Figure 2: Redundancy and pleiotropy of the miRNA regulatory system. The STAT3 gene (green oval)encodes a transcriptional factor. Red ovals are miRNAs downregulating the STAT3 geneexpression. Each of the miRNAs inhibits expression of other target mRNAs (blue, violet,and light blue ovals). Additional miRNAs that may affect the STAT3 gene expression arelisted on the right-hand side. The regulatory network was simulated using theMirtarbase database (http://mirtarbase.mbc.nctu.edu.tw/index.php).

Mentions: Like cytokine action, the miRNA function is characterized by degeneracy(redundancy) and pleiotropy; i.e. the expression level of one mRNA can beregulated by many miRNAs, and one miRNA binds to many target mRNAs, whichresults in the formation of a complex regulatorynetwork (Fig. 2).Thus, a change in the expression of one miRNA may lead to changesin the expression profile of many target mRNAs: however, this effect foreach individual mRNA will also depend on the influence of other miRNAs.


MicroRNAs: The Role in Autoimmune Inflammation.

Baulina NM, Kulakova OG, Favorova OO - Acta Naturae (2016 Jan-Mar)

Redundancy and pleiotropy of the miRNA regulatory system. The STAT3 gene (green oval)encodes a transcriptional factor. Red ovals are miRNAs downregulating the STAT3 geneexpression. Each of the miRNAs inhibits expression of other target mRNAs (blue, violet,and light blue ovals). Additional miRNAs that may affect the STAT3 gene expression arelisted on the right-hand side. The regulatory network was simulated using theMirtarbase database (http://mirtarbase.mbc.nctu.edu.tw/index.php).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837569&req=5

Figure 2: Redundancy and pleiotropy of the miRNA regulatory system. The STAT3 gene (green oval)encodes a transcriptional factor. Red ovals are miRNAs downregulating the STAT3 geneexpression. Each of the miRNAs inhibits expression of other target mRNAs (blue, violet,and light blue ovals). Additional miRNAs that may affect the STAT3 gene expression arelisted on the right-hand side. The regulatory network was simulated using theMirtarbase database (http://mirtarbase.mbc.nctu.edu.tw/index.php).
Mentions: Like cytokine action, the miRNA function is characterized by degeneracy(redundancy) and pleiotropy; i.e. the expression level of one mRNA can beregulated by many miRNAs, and one miRNA binds to many target mRNAs, whichresults in the formation of a complex regulatorynetwork (Fig. 2).Thus, a change in the expression of one miRNA may lead to changesin the expression profile of many target mRNAs: however, this effect foreach individual mRNA will also depend on the influence of other miRNAs.

Bottom Line: MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators.This review summarizes the data on biogenesis and the mechanisms of miRNA action.Currently, a lot of research is focused on this problem.

View Article: PubMed Central - PubMed

Affiliation: Pirogov Russian National Research Medical University, Ostrovityanova St., 1, Moscow, 117997, Russia ; Russian Cardiology Research and Production Complex, 3-rd Cherepkovskay St., 15a, Moscow, 121552 , Russia.

ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3'-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, through a complex regulatory network, the expression of more than 60% of human genes. MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators. Disruption of this regulation may lead to the development of various pathological conditions, including autoimmune inflammation. This review summarizes the data on biogenesis and the mechanisms of miRNA action. We discuss the role of miRNAs in the development and the action of the immune system, as well as in the development of an autoimmune inflammatory response. Special attention is given to the role of miRNAs in the autoimmune inflammation in multiple sclerosis, which is a serious socially significant disease of the central nervous system. Currently, a lot of research is focused on this problem.

No MeSH data available.


Related in: MedlinePlus