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Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus

ENY2 protein knockdown blocks mRNA export from the nucleus to thecytoplasm. Inhibition of protein synthesis is achieved via RNA interference. Asa result, almost all of the poly(A)+RNA remains in the nucleus
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Figure 10: ENY2 protein knockdown blocks mRNA export from the nucleus to thecytoplasm. Inhibition of protein synthesis is achieved via RNA interference. Asa result, almost all of the poly(A)+RNA remains in the nucleus

Mentions: E(y)2/ENY2 was found to be multifunctional. It is part of the DUB module of theSAGA complex and participates in the activation of transcription initiation[30]. ENY2 is also part of the THOprotein complex involved in hnRNA elongation, binding to hnRNP and export ofsome mRNAs. ENY2 is also an important component of the Drosophila AMEX proteincomplex, binding hnRNP and playing a key role in the export of many mRNAs.Knock down of ENY2 by RNA interference leads to complete blockage of mRNAtransport from the nucleus to the cytoplasm. All mRNA accumulate in the nucleus[31](Fig. 10).Finally, ENY2 is part of some insulator complexes, performing the barrierfunction of insulator [32].


Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

ENY2 protein knockdown blocks mRNA export from the nucleus to thecytoplasm. Inhibition of protein synthesis is achieved via RNA interference. Asa result, almost all of the poly(A)+RNA remains in the nucleus
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837567&req=5

Figure 10: ENY2 protein knockdown blocks mRNA export from the nucleus to thecytoplasm. Inhibition of protein synthesis is achieved via RNA interference. Asa result, almost all of the poly(A)+RNA remains in the nucleus
Mentions: E(y)2/ENY2 was found to be multifunctional. It is part of the DUB module of theSAGA complex and participates in the activation of transcription initiation[30]. ENY2 is also part of the THOprotein complex involved in hnRNA elongation, binding to hnRNP and export ofsome mRNAs. ENY2 is also an important component of the Drosophila AMEX proteincomplex, binding hnRNP and playing a key role in the export of many mRNAs.Knock down of ENY2 by RNA interference leads to complete blockage of mRNAtransport from the nucleus to the cytoplasm. All mRNA accumulate in the nucleus[31](Fig. 10).Finally, ENY2 is part of some insulator complexes, performing the barrierfunction of insulator [32].

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus