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Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus

Scheme of the supercomplex with the SAYP protein. The formation ofthe supercomplex dramatically increases the efficiency of TFIID binding with apromoter and transcriptional activity
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Figure 9: Scheme of the supercomplex with the SAYP protein. The formation ofthe supercomplex dramatically increases the efficiency of TFIID binding with apromoter and transcriptional activity

Mentions: SAYP binds the protein initiating complex TFIID and chromatin remodelingcomplex SWI/SNF into a single supercomplex. Knockdown SAYP blocks therecruitment of TFIID and SWI/SNF at the promoter and represses thetranscription of many genes. It can be assumed that the fusion of the complexesallows TFIID to immediately bind to the promoter as soon as theSWI/SNF-activated movement of nucleosomes along the DNA release it from thenucleosomes [29](Fig. 9).


Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

Scheme of the supercomplex with the SAYP protein. The formation ofthe supercomplex dramatically increases the efficiency of TFIID binding with apromoter and transcriptional activity
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837567&req=5

Figure 9: Scheme of the supercomplex with the SAYP protein. The formation ofthe supercomplex dramatically increases the efficiency of TFIID binding with apromoter and transcriptional activity
Mentions: SAYP binds the protein initiating complex TFIID and chromatin remodelingcomplex SWI/SNF into a single supercomplex. Knockdown SAYP blocks therecruitment of TFIID and SWI/SNF at the promoter and represses thetranscription of many genes. It can be assumed that the fusion of the complexesallows TFIID to immediately bind to the promoter as soon as theSWI/SNF-activated movement of nucleosomes along the DNA release it from thenucleosomes [29](Fig. 9).

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus