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Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus

Insulator interactions. Due to the presence of a series of proteins, multiplecontacts are formed in the insulator protein complex and they define strongbinding between insulators and the polarity of their interaction. Only similarlyaligned insulators can bind to each other, which defined the configuration ofthe loop and activation of a gene
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Figure 6: Insulator interactions. Due to the presence of a series of proteins, multiplecontacts are formed in the insulator protein complex and they define strongbinding between insulators and the polarity of their interaction. Only similarlyaligned insulators can bind to each other, which defined the configuration ofthe loop and activation of a gene

Mentions: First of all, new properties belonging to insulators, importantcis-elements in transcription regulation, have been discovered. Theirrole has been found to be highly dependent on their ability to bind tightly toeach other [18, 19].This property depends on the dimerization of a number ofproteins that make up insulator complexes: e.g., the Mod(mdg4) proteindiscovered at the Institute [20](Fig. 6).


Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

Georgiev GP - Acta Naturae (2016 Jan-Mar)

Insulator interactions. Due to the presence of a series of proteins, multiplecontacts are formed in the insulator protein complex and they define strongbinding between insulators and the polarity of their interaction. Only similarlyaligned insulators can bind to each other, which defined the configuration ofthe loop and activation of a gene
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837567&req=5

Figure 6: Insulator interactions. Due to the presence of a series of proteins, multiplecontacts are formed in the insulator protein complex and they define strongbinding between insulators and the polarity of their interaction. Only similarlyaligned insulators can bind to each other, which defined the configuration ofthe loop and activation of a gene
Mentions: First of all, new properties belonging to insulators, importantcis-elements in transcription regulation, have been discovered. Theirrole has been found to be highly dependent on their ability to bind tightly toeach other [18, 19].This property depends on the dimerization of a number ofproteins that make up insulator complexes: e.g., the Mod(mdg4) proteindiscovered at the Institute [20](Fig. 6).

Bottom Line: Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics.However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N.The transcript of the lecture is presented below.

View Article: PubMed Central - PubMed

Affiliation: Institute of Gene Biology, Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

ABSTRACT
On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.

No MeSH data available.


Related in: MedlinePlus