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Peripheral artery disease and exertional leg symptoms in diabetes patients in Ghana.

Yeboah K, Puplampu P, Ainuson J, Akpalu J, Gyan B, Amoah AG - BMC Cardiovasc Disord (2016)

Bottom Line: In multivariable logistic regression, intermittent claudication [OR (95 % CI), 3.39 (1.14 - 8.1), p < 0.05] and rest pain [4.3 (1.58 - 9.67), p < 0.001] were independently associated with PAD in non-diabetes group, and rest pain [1.71 (1.13 - 2.17), p < 0.05] was associated with PAD in all participants.There is high burden of PAD and exertional leg pains in DM patients in Ghana.PAD is expressed as intermittent claudication and rest pain in non-diabetes individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, P. O. Box KB 143, Accra, Ghana. melvinky@gmail.com.

ABSTRACT

Background: Peripheral arterial disease (PAD) is a major health problem in diabetes patients in high-income countries, but the PAD burden in sub-Saharan Africa is largely undetermined. We studied the prevalence of PAD and exertional leg symptoms in diabetes (DM) patients in a tertiary hospital in Ghana.

Methods: In a case control study design, 485 DM and 330 non-diabetes participants were recruited. PAD was diagnosed as Ankle Brachial Index (ABI) < 0.9. Edinburgh Claudication Questionnaire (ECQ) was used to assess exertional leg symptoms.

Results: The overall prevalence of classical intermittent claudication was 10.3 % and ABI-diagnosed PAD was 26.7 %, with 3.5 % of the participants having both classic intermittent claudication and ABI-diagnosed PAD. The prevalence of exertional leg symptoms were similar in diabetes patients with and without PAD. In non-diabetes participants, intermittent claudication and rest pain were higher in PAD patients than in non-PAD participants. In multivariable logistic regression, intermittent claudication [OR (95 % CI), 3.39 (1.14 - 8.1), p < 0.05] and rest pain [4.3 (1.58 - 9.67), p < 0.001] were independently associated with PAD in non-diabetes group, and rest pain [1.71 (1.13 - 2.17), p < 0.05] was associated with PAD in all participants.

Conclusions: There is high burden of PAD and exertional leg pains in DM patients in Ghana. PAD is expressed as intermittent claudication and rest pain in non-diabetes individuals.

No MeSH data available.


Related in: MedlinePlus

Distribution of PAD across age decades
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Fig3: Distribution of PAD across age decades

Mentions: Participants in various ABI categories had similar age, BMI, waist-hip ratio, systolic BP and gender distribution. PAD patients were shorter with higher diastolic BP and heart rate. Exertional leg symptoms were not associated with ABI groups (Table 2). In both genders, PAD prevalence, lower in participants younger than 40 years, increased dramatically from 4th through 6th decades, and reduced after 7th decade of life (Fig. 3). In DM patients, except for underweight group, there was a general increase in age and gender adjusted prevalence of PAD across BMI groups. However, age and gender adjusted prevalence of PAD remained similar in non-diabetes participants across various BMI groups (Fig. 4).Table 2


Peripheral artery disease and exertional leg symptoms in diabetes patients in Ghana.

Yeboah K, Puplampu P, Ainuson J, Akpalu J, Gyan B, Amoah AG - BMC Cardiovasc Disord (2016)

Distribution of PAD across age decades
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837554&req=5

Fig3: Distribution of PAD across age decades
Mentions: Participants in various ABI categories had similar age, BMI, waist-hip ratio, systolic BP and gender distribution. PAD patients were shorter with higher diastolic BP and heart rate. Exertional leg symptoms were not associated with ABI groups (Table 2). In both genders, PAD prevalence, lower in participants younger than 40 years, increased dramatically from 4th through 6th decades, and reduced after 7th decade of life (Fig. 3). In DM patients, except for underweight group, there was a general increase in age and gender adjusted prevalence of PAD across BMI groups. However, age and gender adjusted prevalence of PAD remained similar in non-diabetes participants across various BMI groups (Fig. 4).Table 2

Bottom Line: In multivariable logistic regression, intermittent claudication [OR (95 % CI), 3.39 (1.14 - 8.1), p < 0.05] and rest pain [4.3 (1.58 - 9.67), p < 0.001] were independently associated with PAD in non-diabetes group, and rest pain [1.71 (1.13 - 2.17), p < 0.05] was associated with PAD in all participants.There is high burden of PAD and exertional leg pains in DM patients in Ghana.PAD is expressed as intermittent claudication and rest pain in non-diabetes individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, P. O. Box KB 143, Accra, Ghana. melvinky@gmail.com.

ABSTRACT

Background: Peripheral arterial disease (PAD) is a major health problem in diabetes patients in high-income countries, but the PAD burden in sub-Saharan Africa is largely undetermined. We studied the prevalence of PAD and exertional leg symptoms in diabetes (DM) patients in a tertiary hospital in Ghana.

Methods: In a case control study design, 485 DM and 330 non-diabetes participants were recruited. PAD was diagnosed as Ankle Brachial Index (ABI) < 0.9. Edinburgh Claudication Questionnaire (ECQ) was used to assess exertional leg symptoms.

Results: The overall prevalence of classical intermittent claudication was 10.3 % and ABI-diagnosed PAD was 26.7 %, with 3.5 % of the participants having both classic intermittent claudication and ABI-diagnosed PAD. The prevalence of exertional leg symptoms were similar in diabetes patients with and without PAD. In non-diabetes participants, intermittent claudication and rest pain were higher in PAD patients than in non-PAD participants. In multivariable logistic regression, intermittent claudication [OR (95 % CI), 3.39 (1.14 - 8.1), p < 0.05] and rest pain [4.3 (1.58 - 9.67), p < 0.001] were independently associated with PAD in non-diabetes group, and rest pain [1.71 (1.13 - 2.17), p < 0.05] was associated with PAD in all participants.

Conclusions: There is high burden of PAD and exertional leg pains in DM patients in Ghana. PAD is expressed as intermittent claudication and rest pain in non-diabetes individuals.

No MeSH data available.


Related in: MedlinePlus