Limits...
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.

Wang Y, Zhu YF, Wang Q, Xu J, Yan N, Xu J, Shi LF, He ST, Zhang JA - BMC Endocr Disord (2016)

Bottom Line: Such subphenotypes included GD, HT, and thyroid associated ophthalmopathy (TAO).The negative results were also found in the frequency of other haplotypes of the gene except the haplotype of TCGGC, which was significantly higher in HT group than in control group (P = 0.031, OR = 1.441).The present findings indicate that TCGGC haplotype is associated with an increased risk of HT and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, No. 277 West Yanta Road, Xi'an, 710061, China.

ABSTRACT

Background: The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune thyroid diseases (AITDs) and their clinical phenotypes.

Methods: We genotyped five single-nucleotide polymorphisms (SNPs) rs131654, rs5754217, rs2298428, rs140489 and rs5998672 of UBE2L3 gene in case groups including 1028 patients with AITDs [676 cases of Graves' disease (GD) and 352 cases of Hashimoto's thyroiditis (HT)] and control group including 897 healthy individuals. The genotyping was performed with the method of polymerase chain reaction-ligase detection reaction (PCR-LDR).

Results: The frequencies of allele and genotype of five SNPs in gene UBE2L3 showed no statistically significant difference between case groups and control group, respectively. Moreover, no significant differences in frequencies of allele and genotype of five SNPs of the gene were found between clinical subphenotypes of AITDs and control group. Such subphenotypes included GD, HT, and thyroid associated ophthalmopathy (TAO). The negative results were also found in the frequency of other haplotypes of the gene except the haplotype of TCGGC, which was significantly higher in HT group than in control group (P = 0.031, OR = 1.441).

Conclusions: The present findings indicate that TCGGC haplotype is associated with an increased risk of HT and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

No MeSH data available.


Related in: MedlinePlus

Five SNPs in the same LD block in UBE2L3 from the Hapmap CHB data
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4837539&req=5

Fig1: Five SNPs in the same LD block in UBE2L3 from the Hapmap CHB data

Mentions: We found that five SNPs rs131654, rs5754217, rs2298428, rs5998672, and rs140489 of UBE2L3 region were in the same LD block (65 kilobases) using Hapmap CHB data (corresponding to samples of China ancestry from Beijing) and Haploview software. Strong linkage disequilibrium was shown for five SNPs (Fig. 1).Fig. 1


The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.

Wang Y, Zhu YF, Wang Q, Xu J, Yan N, Xu J, Shi LF, He ST, Zhang JA - BMC Endocr Disord (2016)

Five SNPs in the same LD block in UBE2L3 from the Hapmap CHB data
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4837539&req=5

Fig1: Five SNPs in the same LD block in UBE2L3 from the Hapmap CHB data
Mentions: We found that five SNPs rs131654, rs5754217, rs2298428, rs5998672, and rs140489 of UBE2L3 region were in the same LD block (65 kilobases) using Hapmap CHB data (corresponding to samples of China ancestry from Beijing) and Haploview software. Strong linkage disequilibrium was shown for five SNPs (Fig. 1).Fig. 1

Bottom Line: Such subphenotypes included GD, HT, and thyroid associated ophthalmopathy (TAO).The negative results were also found in the frequency of other haplotypes of the gene except the haplotype of TCGGC, which was significantly higher in HT group than in control group (P = 0.031, OR = 1.441).The present findings indicate that TCGGC haplotype is associated with an increased risk of HT and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, No. 277 West Yanta Road, Xi'an, 710061, China.

ABSTRACT

Background: The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune thyroid diseases (AITDs) and their clinical phenotypes.

Methods: We genotyped five single-nucleotide polymorphisms (SNPs) rs131654, rs5754217, rs2298428, rs140489 and rs5998672 of UBE2L3 gene in case groups including 1028 patients with AITDs [676 cases of Graves' disease (GD) and 352 cases of Hashimoto's thyroiditis (HT)] and control group including 897 healthy individuals. The genotyping was performed with the method of polymerase chain reaction-ligase detection reaction (PCR-LDR).

Results: The frequencies of allele and genotype of five SNPs in gene UBE2L3 showed no statistically significant difference between case groups and control group, respectively. Moreover, no significant differences in frequencies of allele and genotype of five SNPs of the gene were found between clinical subphenotypes of AITDs and control group. Such subphenotypes included GD, HT, and thyroid associated ophthalmopathy (TAO). The negative results were also found in the frequency of other haplotypes of the gene except the haplotype of TCGGC, which was significantly higher in HT group than in control group (P = 0.031, OR = 1.441).

Conclusions: The present findings indicate that TCGGC haplotype is associated with an increased risk of HT and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

No MeSH data available.


Related in: MedlinePlus