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Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.

Weng H, Yan Y, Jin YH, Meng XY, Mo YY, Zeng XT - Sci Rep (2016)

Bottom Line: Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis.No significant association was found between MMP-2-753 C/T and periodontitis susceptibility.Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.

ABSTRACT
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.

No MeSH data available.


Related in: MedlinePlus

Forest plot for MMP-9-1562 C/T polymorphism associated with periodontitis susceptibility in C versus T allele comparison based on random-effects model.
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f2: Forest plot for MMP-9-1562 C/T polymorphism associated with periodontitis susceptibility in C versus T allele comparison based on random-effects model.

Mentions: In all study subjects, meta-analysis showed a reduced risk between the MMP-9-1562 C/T polymorphism and periodontitis susceptibility in all tested genetic model (T vs. C: OR = 0.58, 95% CI = 0.37-0.90; TT vs. CC: OR = 0.17, 95% CI = 0.13–0.23; CT vs. CC: OR = 0.61, 95% CI = 0.41–0.93; TT + CT vs. CC: OR = 0.54, 95% CI = 0.32–0.93; TT vs. CC + CT: OR = 0.28, 95% CI = 0.21–0.36) with some evidence of between-study heterogeneity (Table 2, Fig. 2). Sensitivity analysisby excluding studies with control inconsistent with HWE showed that the decreased risk was only observed in recessive model (OR = 0.41, 95% CI = 0.18–0.93). Stratification analysis by type of disease indicated that individuals were more susceptible to CP than AgP (Table 2).


Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.

Weng H, Yan Y, Jin YH, Meng XY, Mo YY, Zeng XT - Sci Rep (2016)

Forest plot for MMP-9-1562 C/T polymorphism associated with periodontitis susceptibility in C versus T allele comparison based on random-effects model.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837403&req=5

f2: Forest plot for MMP-9-1562 C/T polymorphism associated with periodontitis susceptibility in C versus T allele comparison based on random-effects model.
Mentions: In all study subjects, meta-analysis showed a reduced risk between the MMP-9-1562 C/T polymorphism and periodontitis susceptibility in all tested genetic model (T vs. C: OR = 0.58, 95% CI = 0.37-0.90; TT vs. CC: OR = 0.17, 95% CI = 0.13–0.23; CT vs. CC: OR = 0.61, 95% CI = 0.41–0.93; TT + CT vs. CC: OR = 0.54, 95% CI = 0.32–0.93; TT vs. CC + CT: OR = 0.28, 95% CI = 0.21–0.36) with some evidence of between-study heterogeneity (Table 2, Fig. 2). Sensitivity analysisby excluding studies with control inconsistent with HWE showed that the decreased risk was only observed in recessive model (OR = 0.41, 95% CI = 0.18–0.93). Stratification analysis by type of disease indicated that individuals were more susceptible to CP than AgP (Table 2).

Bottom Line: Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis.No significant association was found between MMP-2-753 C/T and periodontitis susceptibility.Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.

ABSTRACT
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.

No MeSH data available.


Related in: MedlinePlus