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Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.

Weng H, Yan Y, Jin YH, Meng XY, Mo YY, Zeng XT - Sci Rep (2016)

Bottom Line: Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis.No significant association was found between MMP-2-753 C/T and periodontitis susceptibility.Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.

ABSTRACT
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.

No MeSH data available.


Related in: MedlinePlus

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f1: Flow chart for this meta-analysis.

Mentions: As shown in Fig. 1, we initially identified 142 articles. Finally we included 16 articles26272829303132333435363738394041 with 24 case-control studies involving 2,724 cases and 3,438 controls. Among them, there were four polymorphisms of MMP gene included in our meta-analysis: nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T. Two of these studies2837 contained data on two different groups (CP and AgP), which were considered independently. One article contained two independent case-control studies in different countries and in this study only allele number was available39. Three articles274041 were focused on two polymorphisms, and two articles3132 were focused on three polymorphisms, which were treated as independent case-control studies as well. Four articles with six case-control studies did not satisfy the HWE for control group26394041. Main characteristics of included studies were summarized in Table 1.


Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.

Weng H, Yan Y, Jin YH, Meng XY, Mo YY, Zeng XT - Sci Rep (2016)

Flow chart for this meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837403&req=5

f1: Flow chart for this meta-analysis.
Mentions: As shown in Fig. 1, we initially identified 142 articles. Finally we included 16 articles26272829303132333435363738394041 with 24 case-control studies involving 2,724 cases and 3,438 controls. Among them, there were four polymorphisms of MMP gene included in our meta-analysis: nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T. Two of these studies2837 contained data on two different groups (CP and AgP), which were considered independently. One article contained two independent case-control studies in different countries and in this study only allele number was available39. Three articles274041 were focused on two polymorphisms, and two articles3132 were focused on three polymorphisms, which were treated as independent case-control studies as well. Four articles with six case-control studies did not satisfy the HWE for control group26394041. Main characteristics of included studies were summarized in Table 1.

Bottom Line: Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis.No significant association was found between MMP-2-753 C/T and periodontitis susceptibility.Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.

ABSTRACT
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.

No MeSH data available.


Related in: MedlinePlus