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Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise.

Sarrami-Foroushani A, Nasr Esfahany M, Saligheh Rad H, Firouznia K, Shakiba M, Ghanaati H - Iran J Radiol (2016)

Bottom Line: The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.Results showed significant changes for the three simulated states.For a proportion of the states examined, results were counterintuitive.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran.

ABSTRACT

Background: Hemodynamics is thought to play an important role in the mechanisms responsible for initiation, growth, and rupture of intracranial aneurysms. Computational fluid dynamic (CFD) analysis is used to assess intra-aneurysmal hemodynamics.

Objectives: This study aimed to investigate the effects of variations in heart rate and internal carotid artery (ICA) flow rate on intra-aneurysmal hemodynamics, in an ICA aneurysm, by using computational fluid dynamics.

Patients and methods: Computed tomography angiography (CTA) was performed in a 55 years old female case, with a saccular ICA aneurysm, to create a patient-specific geometrical anatomic model of the aneurysm. The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.

Results: Results showed significant changes for the three simulated states. For a proportion of the states examined, results were counterintuitive. Systolic and time-averaged wall shear stress and pressure on the aneurysm wall showed a proportional evolution with the mainstream flow rate.

Conclusion: Results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific CFD analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated.

No MeSH data available.


Related in: MedlinePlus

Pressure distributions for three states at peak systole. The impingement point is shown by a small violet ball on each contour.
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fig23831: Pressure distributions for three states at peak systole. The impingement point is shown by a small violet ball on each contour.

Mentions: Figure 3 depicts the distribution of aneurysmal wall pressure at peak systole. An impingement region, concentrated at the aneurysm neck, was observed for all states (marked by a small ball on Figure 3). The location of impingement region slightly changed in state 3 and interestingly, in state 2, the maximum pressure at the aneurysm neck and also the pressure on the aneurysm apex were higher than the two other states. There is an area of elevated pressure on the aneurysm apex in states 1 and 2, which has disappeared in state 3.


Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise.

Sarrami-Foroushani A, Nasr Esfahany M, Saligheh Rad H, Firouznia K, Shakiba M, Ghanaati H - Iran J Radiol (2016)

Pressure distributions for three states at peak systole. The impingement point is shown by a small violet ball on each contour.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837368&req=5

fig23831: Pressure distributions for three states at peak systole. The impingement point is shown by a small violet ball on each contour.
Mentions: Figure 3 depicts the distribution of aneurysmal wall pressure at peak systole. An impingement region, concentrated at the aneurysm neck, was observed for all states (marked by a small ball on Figure 3). The location of impingement region slightly changed in state 3 and interestingly, in state 2, the maximum pressure at the aneurysm neck and also the pressure on the aneurysm apex were higher than the two other states. There is an area of elevated pressure on the aneurysm apex in states 1 and 2, which has disappeared in state 3.

Bottom Line: The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.Results showed significant changes for the three simulated states.For a proportion of the states examined, results were counterintuitive.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran.

ABSTRACT

Background: Hemodynamics is thought to play an important role in the mechanisms responsible for initiation, growth, and rupture of intracranial aneurysms. Computational fluid dynamic (CFD) analysis is used to assess intra-aneurysmal hemodynamics.

Objectives: This study aimed to investigate the effects of variations in heart rate and internal carotid artery (ICA) flow rate on intra-aneurysmal hemodynamics, in an ICA aneurysm, by using computational fluid dynamics.

Patients and methods: Computed tomography angiography (CTA) was performed in a 55 years old female case, with a saccular ICA aneurysm, to create a patient-specific geometrical anatomic model of the aneurysm. The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.

Results: Results showed significant changes for the three simulated states. For a proportion of the states examined, results were counterintuitive. Systolic and time-averaged wall shear stress and pressure on the aneurysm wall showed a proportional evolution with the mainstream flow rate.

Conclusion: Results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific CFD analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated.

No MeSH data available.


Related in: MedlinePlus