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Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise.

Sarrami-Foroushani A, Nasr Esfahany M, Saligheh Rad H, Firouznia K, Shakiba M, Ghanaati H - Iran J Radiol (2016)

Bottom Line: The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.Results showed significant changes for the three simulated states.For a proportion of the states examined, results were counterintuitive.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran.

ABSTRACT

Background: Hemodynamics is thought to play an important role in the mechanisms responsible for initiation, growth, and rupture of intracranial aneurysms. Computational fluid dynamic (CFD) analysis is used to assess intra-aneurysmal hemodynamics.

Objectives: This study aimed to investigate the effects of variations in heart rate and internal carotid artery (ICA) flow rate on intra-aneurysmal hemodynamics, in an ICA aneurysm, by using computational fluid dynamics.

Patients and methods: Computed tomography angiography (CTA) was performed in a 55 years old female case, with a saccular ICA aneurysm, to create a patient-specific geometrical anatomic model of the aneurysm. The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.

Results: Results showed significant changes for the three simulated states. For a proportion of the states examined, results were counterintuitive. Systolic and time-averaged wall shear stress and pressure on the aneurysm wall showed a proportional evolution with the mainstream flow rate.

Conclusion: Results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific CFD analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated.

No MeSH data available.


Related in: MedlinePlus

Wall shear stress distributions for three states time-averaged over a cardiac cycle (first row) and at peak systole (second row).
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fig23830: Wall shear stress distributions for three states time-averaged over a cardiac cycle (first row) and at peak systole (second row).

Mentions: Distributions of WSS, time-averaged over a cardiac cycle on the aneurysmal wall, are shown in Figure 2 for the three states (first row). For all states, areas of elevated WSS were observed around the aneurysm neck and the remainder of the aneurysm wall was exposed to low WSS. Visual comparison of the states showed an increase in WSS in state 2, compared to state 1, whereas time-averaged WSS decreased in state 3, although blood flow and heart rate were increased in this state. Figure 2 also shows the distribution of WSS on the aneurysm region at peak systole, for each state. Systolic WSS, however, increased, as flow and heart rate increased in all states.


Effects of Variations of Flow and Heart Rate on Intra-Aneurysmal Hemodynamics in a Ruptured Internal Carotid Artery Aneurysm During Exercise.

Sarrami-Foroushani A, Nasr Esfahany M, Saligheh Rad H, Firouznia K, Shakiba M, Ghanaati H - Iran J Radiol (2016)

Wall shear stress distributions for three states time-averaged over a cardiac cycle (first row) and at peak systole (second row).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837368&req=5

fig23830: Wall shear stress distributions for three states time-averaged over a cardiac cycle (first row) and at peak systole (second row).
Mentions: Distributions of WSS, time-averaged over a cardiac cycle on the aneurysmal wall, are shown in Figure 2 for the three states (first row). For all states, areas of elevated WSS were observed around the aneurysm neck and the remainder of the aneurysm wall was exposed to low WSS. Visual comparison of the states showed an increase in WSS in state 2, compared to state 1, whereas time-averaged WSS decreased in state 3, although blood flow and heart rate were increased in this state. Figure 2 also shows the distribution of WSS on the aneurysm region at peak systole, for each state. Systolic WSS, however, increased, as flow and heart rate increased in all states.

Bottom Line: The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.Results showed significant changes for the three simulated states.For a proportion of the states examined, results were counterintuitive.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran.

ABSTRACT

Background: Hemodynamics is thought to play an important role in the mechanisms responsible for initiation, growth, and rupture of intracranial aneurysms. Computational fluid dynamic (CFD) analysis is used to assess intra-aneurysmal hemodynamics.

Objectives: This study aimed to investigate the effects of variations in heart rate and internal carotid artery (ICA) flow rate on intra-aneurysmal hemodynamics, in an ICA aneurysm, by using computational fluid dynamics.

Patients and methods: Computed tomography angiography (CTA) was performed in a 55 years old female case, with a saccular ICA aneurysm, to create a patient-specific geometrical anatomic model of the aneurysm. The intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based CFD modeling.

Results: Results showed significant changes for the three simulated states. For a proportion of the states examined, results were counterintuitive. Systolic and time-averaged wall shear stress and pressure on the aneurysm wall showed a proportional evolution with the mainstream flow rate.

Conclusion: Results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific CFD analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated.

No MeSH data available.


Related in: MedlinePlus