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Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A - Sci Rep (2016)

Bottom Line: We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK.Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)).We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births.

View Article: PubMed Central - PubMed

Affiliation: Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon &Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

ABSTRACT
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥ 45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.

No MeSH data available.


Related in: MedlinePlus

Associations in the multiple early-life risk factor model.Results shown are for the logistic regression model in all age groups including all early-life risk factors at the same time (n = 78,603), adjusted for the potential confounding variables Townsend deprivation index, BMI, smoking status, smoking pack-years, frequency of alcohol intake, number of live births, educational level and whether the participant ate meat. The early life risk-factors included are age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10. Cancer at under 20 years and year of birth were not included due to the small number of cases in the former, and confounding with age at recruitment in the latter. Confidence intervals are 99.995%.
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f4: Associations in the multiple early-life risk factor model.Results shown are for the logistic regression model in all age groups including all early-life risk factors at the same time (n = 78,603), adjusted for the potential confounding variables Townsend deprivation index, BMI, smoking status, smoking pack-years, frequency of alcohol intake, number of live births, educational level and whether the participant ate meat. The early life risk-factors included are age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10. Cancer at under 20 years and year of birth were not included due to the small number of cases in the former, and confounding with age at recruitment in the latter. Confidence intervals are 99.995%.

Mentions: In a fully-adjusted model including all early-life risk factors that were associated with EM (age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10), only the risk factors younger age at menarche (OR = 1.05, CI: 1.0, 1.09, P = 7.27 × 10−6) and being part of a multiple birth (OR = 1.55, CI: 1.13, 2.13, P = 2.11 × 10−8) remained significantly associated with EM (Fig. 4, Supplementary Table 7). Only age at menarche remained significantly associated in the Cox model including all early-life risk factors (Supplementary Table 7). Cancer at under 20 years and year of birth were not included in the model including all early-life risk factors, due to the small number of cases in the former, and bias due to age at recruitment in the latter.


Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A - Sci Rep (2016)

Associations in the multiple early-life risk factor model.Results shown are for the logistic regression model in all age groups including all early-life risk factors at the same time (n = 78,603), adjusted for the potential confounding variables Townsend deprivation index, BMI, smoking status, smoking pack-years, frequency of alcohol intake, number of live births, educational level and whether the participant ate meat. The early life risk-factors included are age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10. Cancer at under 20 years and year of birth were not included due to the small number of cases in the former, and confounding with age at recruitment in the latter. Confidence intervals are 99.995%.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837365&req=5

f4: Associations in the multiple early-life risk factor model.Results shown are for the logistic regression model in all age groups including all early-life risk factors at the same time (n = 78,603), adjusted for the potential confounding variables Townsend deprivation index, BMI, smoking status, smoking pack-years, frequency of alcohol intake, number of live births, educational level and whether the participant ate meat. The early life risk-factors included are age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10. Cancer at under 20 years and year of birth were not included due to the small number of cases in the former, and confounding with age at recruitment in the latter. Confidence intervals are 99.995%.
Mentions: In a fully-adjusted model including all early-life risk factors that were associated with EM (age at menarche, birth weight, maternal smoking, breast fed as a baby, part of multiple birth and comparative body size at age 10), only the risk factors younger age at menarche (OR = 1.05, CI: 1.0, 1.09, P = 7.27 × 10−6) and being part of a multiple birth (OR = 1.55, CI: 1.13, 2.13, P = 2.11 × 10−8) remained significantly associated with EM (Fig. 4, Supplementary Table 7). Only age at menarche remained significantly associated in the Cox model including all early-life risk factors (Supplementary Table 7). Cancer at under 20 years and year of birth were not included in the model including all early-life risk factors, due to the small number of cases in the former, and bias due to age at recruitment in the latter.

Bottom Line: We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK.Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)).We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births.

View Article: PubMed Central - PubMed

Affiliation: Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon &Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

ABSTRACT
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥ 45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.

No MeSH data available.


Related in: MedlinePlus