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Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A - Sci Rep (2016)

Bottom Line: We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK.Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)).We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births.

View Article: PubMed Central - PubMed

Affiliation: Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon &Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

ABSTRACT
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥ 45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.

No MeSH data available.


Related in: MedlinePlus

Selection of data used in the analysis.
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f1: Selection of data used in the analysis.

Mentions: We considered the outcome EM in our analyses, since this is clinically relevant and captures the lower extreme of normal reproductive ageing. EM cases were women with menopause under 45 years while controls had menopause or were known to be pre-menopausal at age 45 or over. Age at natural menopause was defined as age at last menstrual period excluding those with surgical menopause or taking hormone replacement therapy (further details in Supplementary Methods). Of the 257,503 white women, there were 11,781 EM cases (4.6%) and 173,641 controls (67.4%) (Fig. 1).


Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A - Sci Rep (2016)

Selection of data used in the analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4837365&req=5

f1: Selection of data used in the analysis.
Mentions: We considered the outcome EM in our analyses, since this is clinically relevant and captures the lower extreme of normal reproductive ageing. EM cases were women with menopause under 45 years while controls had menopause or were known to be pre-menopausal at age 45 or over. Age at natural menopause was defined as age at last menstrual period excluding those with surgical menopause or taking hormone replacement therapy (further details in Supplementary Methods). Of the 257,503 white women, there were 11,781 EM cases (4.6%) and 173,641 controls (67.4%) (Fig. 1).

Bottom Line: We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK.Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)).We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births.

View Article: PubMed Central - PubMed

Affiliation: Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon &Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.

ABSTRACT
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥ 45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.

No MeSH data available.


Related in: MedlinePlus