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Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness.

Pan MM, Kovac JR - Transl Androl Urol (2016)

Bottom Line: Containing a chemical structure similar to testosterone, nandrolone has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass.Animal models have suggested application in the improvement of joint healing following rotator cuff repair.Minimal literature exists regarding the use of nandrolone and, as such, further human studies are required.

View Article: PubMed Central - PubMed

Affiliation: 1 Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA ; 2 Men's Health Center, Urology of Indiana, Indianapolis, Indiana 46260, USA.

ABSTRACT
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health. Containing a chemical structure similar to testosterone, nandrolone has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass. Animal models have suggested application in the improvement of joint healing following rotator cuff repair. Minimal literature exists regarding the use of nandrolone and, as such, further human studies are required.

No MeSH data available.


Related in: MedlinePlus

Comparison of molecular structures of testosterone and 19-nortestosterone (nandrolone).
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Related In: Results  -  Collection


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f1: Comparison of molecular structures of testosterone and 19-nortestosterone (nandrolone).

Mentions: Nandrolone is a synthetic anabolic steroid that bears similarity in chemical appearance to testosterone. The only major difference between the two molecules is a single methyl group (see Figure 1). Similar to testosterone, nandrolone is administered via intramuscular (IM) injection and has a plasma half-life of approximately 8 days (7). Nandrolone binds to androgen receptors with a greater binding affinity than testosterone and with an increased anabolic, or myotrophic, activity rate (versus androgenic activity) (15). For example and to assist in comparison, the myotrophic:androgenic ratio can be used to compare testosterone (~1:1) to nandrolone (~11:1) (15) with regards to the ability to stimulate muscle growth compared to virilization.


Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness.

Pan MM, Kovac JR - Transl Androl Urol (2016)

Comparison of molecular structures of testosterone and 19-nortestosterone (nandrolone).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4837307&req=5

f1: Comparison of molecular structures of testosterone and 19-nortestosterone (nandrolone).
Mentions: Nandrolone is a synthetic anabolic steroid that bears similarity in chemical appearance to testosterone. The only major difference between the two molecules is a single methyl group (see Figure 1). Similar to testosterone, nandrolone is administered via intramuscular (IM) injection and has a plasma half-life of approximately 8 days (7). Nandrolone binds to androgen receptors with a greater binding affinity than testosterone and with an increased anabolic, or myotrophic, activity rate (versus androgenic activity) (15). For example and to assist in comparison, the myotrophic:androgenic ratio can be used to compare testosterone (~1:1) to nandrolone (~11:1) (15) with regards to the ability to stimulate muscle growth compared to virilization.

Bottom Line: Containing a chemical structure similar to testosterone, nandrolone has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass.Animal models have suggested application in the improvement of joint healing following rotator cuff repair.Minimal literature exists regarding the use of nandrolone and, as such, further human studies are required.

View Article: PubMed Central - PubMed

Affiliation: 1 Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA ; 2 Men's Health Center, Urology of Indiana, Indianapolis, Indiana 46260, USA.

ABSTRACT
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health. Containing a chemical structure similar to testosterone, nandrolone has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass. Animal models have suggested application in the improvement of joint healing following rotator cuff repair. Minimal literature exists regarding the use of nandrolone and, as such, further human studies are required.

No MeSH data available.


Related in: MedlinePlus