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Effects of a buried magnetic field on cranial bone reconstruction in rats.

Abreu MC, Ponzoni D, Langie R, Artuzi FE, Puricelli E - J Appl Oral Sci (2016)

Bottom Line: Results These analyses showed significant group by postoperative time interactions (p=0.008).Results also showed that the quality of bone repair remained higher in the former group as compared to the latter at 60 postoperative days.Conclusions After 60 postoperative days, bone repair was greater in the group treated with autogenous bone grafts and exposed to a magnetic field, and bone repair was most pronounced in animals treated with autogenous bone grafts, followed by those treated with powdered synthetic hydroxyapatite and allogeneic cartilage grafts.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Cirurgia Oral e Maxilofacial, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

ABSTRACT
The understanding of bone repair phenomena is a fundamental part of dentistry and maxillofacial surgery. Objective The present study aimed to evaluate the influence of buried magnetic field stimulation on bone repair in rat calvaria after reconstruction with autogenous bone grafts, synthetic powdered hydroxyapatite, or allogeneic cartilage grafts, with or without exposure to magnetic stimulation. Material and Methods Ninety male Wistar rats were divided into 18 groups of five animals each. Critical bone defects were created in the rats' calvaria and immediately reconstructed with autogenous bone, powdered synthetic hydroxyapatite or allogeneic cartilage. Magnetic implants were also placed in half the animals. Rats were euthanized for analysis at 15, 30, and 60 postoperative days. Histomorphometric analyses of the quantity of bone repair were performed at all times. Results These analyses showed significant group by postoperative time interactions (p=0.008). Among the rats subjected to autogenous bone reconstruction, those exposed to magnetic stimulation had higher bone fill percentages than those without magnetic implants. Results also showed that the quality of bone repair remained higher in the former group as compared to the latter at 60 postoperative days. Conclusions After 60 postoperative days, bone repair was greater in the group treated with autogenous bone grafts and exposed to a magnetic field, and bone repair was most pronounced in animals treated with autogenous bone grafts, followed by those treated with powdered synthetic hydroxyapatite and allogeneic cartilage grafts.

No MeSH data available.


Related in: MedlinePlus

Histomorphometric analysis after reconstruction with autogenous bone graft, powdered synthetic hydroxyapatite implant, andallogeneic cartilage graft, with or without exposure to buried magnetic field, at 60 postoperative days (Blue lines define the total area of the bone defects, and cross hatched areas represent areas of new bone formation within the critical defect). d) Powdered synthetic hydroxyapatite group exposed to buried magnetic stimulation; e) Autogenous bone graft group not exposed to buried magnetic stimulation; f) Autogenous bone graft group exposed to buried magnetic stimulation. * indicates cartilage graft; # indicates hydroxyapatite implant; ++ indicates bone graft
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f03: Histomorphometric analysis after reconstruction with autogenous bone graft, powdered synthetic hydroxyapatite implant, andallogeneic cartilage graft, with or without exposure to buried magnetic field, at 60 postoperative days (Blue lines define the total area of the bone defects, and cross hatched areas represent areas of new bone formation within the critical defect). d) Powdered synthetic hydroxyapatite group exposed to buried magnetic stimulation; e) Autogenous bone graft group not exposed to buried magnetic stimulation; f) Autogenous bone graft group exposed to buried magnetic stimulation. * indicates cartilage graft; # indicates hydroxyapatite implant; ++ indicates bone graft

Mentions: Between-group comparisons of bone fill percentage at 15 postoperative days showed that the autogenous bone graft with magnetic field group (AB+M) had a higher bone fill percentage than the allogeneic cartilage graft without magnetic field group (CT) – indicated in the graph for *. At 30 postoperative days, the bone fill percentage of AB+M rats was still higher than observed in the CT group, and was also significantly greater than that seen in the hydroxyapatite implant with magnetic field group (HA+M) – indicated in the graph for #. After 60 days, the HA+M group showed a higher bone fill percentage than the CT group – indicated in the graph for +, and the AB+M group had higher bone fill than the CT and autogenous bone graft without magnetic field (AB) groups – indicated in the graph for **. These results showed that 60 days after autogenous bone reconstruction, rats exposed to magnetic fields had a higher bone fill percentage than those without stimulation (Figure 3).


Effects of a buried magnetic field on cranial bone reconstruction in rats.

Abreu MC, Ponzoni D, Langie R, Artuzi FE, Puricelli E - J Appl Oral Sci (2016)

Histomorphometric analysis after reconstruction with autogenous bone graft, powdered synthetic hydroxyapatite implant, andallogeneic cartilage graft, with or without exposure to buried magnetic field, at 60 postoperative days (Blue lines define the total area of the bone defects, and cross hatched areas represent areas of new bone formation within the critical defect). d) Powdered synthetic hydroxyapatite group exposed to buried magnetic stimulation; e) Autogenous bone graft group not exposed to buried magnetic stimulation; f) Autogenous bone graft group exposed to buried magnetic stimulation. * indicates cartilage graft; # indicates hydroxyapatite implant; ++ indicates bone graft
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836924&req=5

f03: Histomorphometric analysis after reconstruction with autogenous bone graft, powdered synthetic hydroxyapatite implant, andallogeneic cartilage graft, with or without exposure to buried magnetic field, at 60 postoperative days (Blue lines define the total area of the bone defects, and cross hatched areas represent areas of new bone formation within the critical defect). d) Powdered synthetic hydroxyapatite group exposed to buried magnetic stimulation; e) Autogenous bone graft group not exposed to buried magnetic stimulation; f) Autogenous bone graft group exposed to buried magnetic stimulation. * indicates cartilage graft; # indicates hydroxyapatite implant; ++ indicates bone graft
Mentions: Between-group comparisons of bone fill percentage at 15 postoperative days showed that the autogenous bone graft with magnetic field group (AB+M) had a higher bone fill percentage than the allogeneic cartilage graft without magnetic field group (CT) – indicated in the graph for *. At 30 postoperative days, the bone fill percentage of AB+M rats was still higher than observed in the CT group, and was also significantly greater than that seen in the hydroxyapatite implant with magnetic field group (HA+M) – indicated in the graph for #. After 60 days, the HA+M group showed a higher bone fill percentage than the CT group – indicated in the graph for +, and the AB+M group had higher bone fill than the CT and autogenous bone graft without magnetic field (AB) groups – indicated in the graph for **. These results showed that 60 days after autogenous bone reconstruction, rats exposed to magnetic fields had a higher bone fill percentage than those without stimulation (Figure 3).

Bottom Line: Results These analyses showed significant group by postoperative time interactions (p=0.008).Results also showed that the quality of bone repair remained higher in the former group as compared to the latter at 60 postoperative days.Conclusions After 60 postoperative days, bone repair was greater in the group treated with autogenous bone grafts and exposed to a magnetic field, and bone repair was most pronounced in animals treated with autogenous bone grafts, followed by those treated with powdered synthetic hydroxyapatite and allogeneic cartilage grafts.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Cirurgia Oral e Maxilofacial, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

ABSTRACT
The understanding of bone repair phenomena is a fundamental part of dentistry and maxillofacial surgery. Objective The present study aimed to evaluate the influence of buried magnetic field stimulation on bone repair in rat calvaria after reconstruction with autogenous bone grafts, synthetic powdered hydroxyapatite, or allogeneic cartilage grafts, with or without exposure to magnetic stimulation. Material and Methods Ninety male Wistar rats were divided into 18 groups of five animals each. Critical bone defects were created in the rats' calvaria and immediately reconstructed with autogenous bone, powdered synthetic hydroxyapatite or allogeneic cartilage. Magnetic implants were also placed in half the animals. Rats were euthanized for analysis at 15, 30, and 60 postoperative days. Histomorphometric analyses of the quantity of bone repair were performed at all times. Results These analyses showed significant group by postoperative time interactions (p=0.008). Among the rats subjected to autogenous bone reconstruction, those exposed to magnetic stimulation had higher bone fill percentages than those without magnetic implants. Results also showed that the quality of bone repair remained higher in the former group as compared to the latter at 60 postoperative days. Conclusions After 60 postoperative days, bone repair was greater in the group treated with autogenous bone grafts and exposed to a magnetic field, and bone repair was most pronounced in animals treated with autogenous bone grafts, followed by those treated with powdered synthetic hydroxyapatite and allogeneic cartilage grafts.

No MeSH data available.


Related in: MedlinePlus