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Improving the Stability of Astaxanthin by Microencapsulation in Calcium Alginate Beads.

Lin SF, Chen YC, Chen RN, Chen LC, Ho HO, Tsung YH, Sheu MT, Liu DZ - PLoS ONE (2016)

Bottom Line: The evaluation of astaxanthin stability under various environmental factors reveals that temperature is the most influential environmental factor in astaxanthin degradation.Stability analysis shows that, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remains above 90% of the original amount after 21 days of storage at 25°C.These results suggest that the proposed technique is a promising way to enhance the stability of other sensitive compounds.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University, Taipei, Taiwan (ROC).

ABSTRACT
There has been considerable interest in the biological functions of astaxanthin and its potential applications in the nutraceutical, cosmetics, food, and feed industries in recent years. However, the unstable structure of astaxanthin considerably limits its application. Therefore, this study reports the encapsulation of astaxanthin in calcium alginate beads using the extrusion method to improve its stability. This study also evaluates the stability of the encapsulated astaxanthin under different storage conditions. The evaluation of astaxanthin stability under various environmental factors reveals that temperature is the most influential environmental factor in astaxanthin degradation. Stability analysis shows that, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remains above 90% of the original amount after 21 days of storage at 25°C. These results suggest that the proposed technique is a promising way to enhance the stability of other sensitive compounds.

No MeSH data available.


Related in: MedlinePlus

The enhanced stability of astaxanthin encapsulated alginate beads with various formulations under storage conditions at 25°C, RH 60% (A) and 40°C, RH 75% (B). C-1: the control sample of Carophyll® Pink 10% CWS; C-2: the control sample of pure astaxanthin raw material.
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pone.0153685.g005: The enhanced stability of astaxanthin encapsulated alginate beads with various formulations under storage conditions at 25°C, RH 60% (A) and 40°C, RH 75% (B). C-1: the control sample of Carophyll® Pink 10% CWS; C-2: the control sample of pure astaxanthin raw material.

Mentions: To determine the enhanced stability of encapsulated astaxanthin under different storage conditions (25°C, RH 60%, 40°C, and RH 75%), this study compares the stability of astaxanthin, encapsulated astaxanthin with various formulations, and Carophyll® Pink, a commercial product containing 10% astaxanthin. A pre-study first evaluated the stability of astaxanthin under various environmental factors such as light, nitrogen storage, and temperature. Results show that astaxanthin is most sensitive to high temperature, agreeing with the results of Kittikaiwan et al. [15]. Hence, the storage conditions were set at 40°C and 25°C to test stability. The astaxanthin contents of various formulations of alginate beads and controls were measured periodically during the 21 d of the study. The results in Fig 5 indicate that, regardless of the storage conditions, the content of astaxanthin encapsulated in alginate beads was significantly higher than the two controls (without encapsulation). This can be explained by the reason that the alginate matrix protects the astaxanthin from thermal degradation and blocks the attack of oxygen. Note that the extraction method caused some fluctuations in astaxanthin content during storage, indicating that the technique of extracting astaxanthin from alginate beads can be improved. After 21 d of storage at 25°C, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remained more than 90% of the original amount. These results demonstrate that the proposed technique can be used to enhance the stability of other sensitive compounds.


Improving the Stability of Astaxanthin by Microencapsulation in Calcium Alginate Beads.

Lin SF, Chen YC, Chen RN, Chen LC, Ho HO, Tsung YH, Sheu MT, Liu DZ - PLoS ONE (2016)

The enhanced stability of astaxanthin encapsulated alginate beads with various formulations under storage conditions at 25°C, RH 60% (A) and 40°C, RH 75% (B). C-1: the control sample of Carophyll® Pink 10% CWS; C-2: the control sample of pure astaxanthin raw material.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836734&req=5

pone.0153685.g005: The enhanced stability of astaxanthin encapsulated alginate beads with various formulations under storage conditions at 25°C, RH 60% (A) and 40°C, RH 75% (B). C-1: the control sample of Carophyll® Pink 10% CWS; C-2: the control sample of pure astaxanthin raw material.
Mentions: To determine the enhanced stability of encapsulated astaxanthin under different storage conditions (25°C, RH 60%, 40°C, and RH 75%), this study compares the stability of astaxanthin, encapsulated astaxanthin with various formulations, and Carophyll® Pink, a commercial product containing 10% astaxanthin. A pre-study first evaluated the stability of astaxanthin under various environmental factors such as light, nitrogen storage, and temperature. Results show that astaxanthin is most sensitive to high temperature, agreeing with the results of Kittikaiwan et al. [15]. Hence, the storage conditions were set at 40°C and 25°C to test stability. The astaxanthin contents of various formulations of alginate beads and controls were measured periodically during the 21 d of the study. The results in Fig 5 indicate that, regardless of the storage conditions, the content of astaxanthin encapsulated in alginate beads was significantly higher than the two controls (without encapsulation). This can be explained by the reason that the alginate matrix protects the astaxanthin from thermal degradation and blocks the attack of oxygen. Note that the extraction method caused some fluctuations in astaxanthin content during storage, indicating that the technique of extracting astaxanthin from alginate beads can be improved. After 21 d of storage at 25°C, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remained more than 90% of the original amount. These results demonstrate that the proposed technique can be used to enhance the stability of other sensitive compounds.

Bottom Line: The evaluation of astaxanthin stability under various environmental factors reveals that temperature is the most influential environmental factor in astaxanthin degradation.Stability analysis shows that, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remains above 90% of the original amount after 21 days of storage at 25°C.These results suggest that the proposed technique is a promising way to enhance the stability of other sensitive compounds.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University, Taipei, Taiwan (ROC).

ABSTRACT
There has been considerable interest in the biological functions of astaxanthin and its potential applications in the nutraceutical, cosmetics, food, and feed industries in recent years. However, the unstable structure of astaxanthin considerably limits its application. Therefore, this study reports the encapsulation of astaxanthin in calcium alginate beads using the extrusion method to improve its stability. This study also evaluates the stability of the encapsulated astaxanthin under different storage conditions. The evaluation of astaxanthin stability under various environmental factors reveals that temperature is the most influential environmental factor in astaxanthin degradation. Stability analysis shows that, regardless of the formulation used, the content of astaxanthin encapsulated in alginate beads remains above 90% of the original amount after 21 days of storage at 25°C. These results suggest that the proposed technique is a promising way to enhance the stability of other sensitive compounds.

No MeSH data available.


Related in: MedlinePlus