Limits...
The Ancient Evolutionary History of Polyomaviruses.

Buck CB, Van Doorslaer K, Peretti A, Geoghegan EM, Tisza MJ, An P, Katz JP, Pipas JM, McBride AA, Camus AC, McDermott AJ, Dill JA, Delwart E, Ng TF, Farkas K, Austin C, Kraberger S, Davison W, Pastrana DV, Varsani A - PLoS Pathog. (2016)

Bottom Line: To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods.Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages.The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

View Article: PubMed Central - PubMed

Affiliation: Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.

ABSTRACT
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

Show MeSH

Related in: MedlinePlus

Virus-host co-divergence plot.SDT software was used to score individual pairs of polyomaviruses within various clades for percent divergence across the entire viral genome. The nucleotide divergence score was plotted against the estimated time (in millions of years ago, mya) of the last common ancestor of the host animals in which the polyomavirus pair was found. Apparent recent transmission of some Avi polyomaviruses between distantly related bird species is represented by points close to the x-axis. The absence of such points in the Almi and Ortho clades indicates a lack of evidence for recent transmission of polyomaviruses between distantly related mammal species. The arbitrary dashed reference line has a slope of about 0.5% polyomavirus divergence per million years after host divergence.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4836724&req=5

ppat.1005574.g007: Virus-host co-divergence plot.SDT software was used to score individual pairs of polyomaviruses within various clades for percent divergence across the entire viral genome. The nucleotide divergence score was plotted against the estimated time (in millions of years ago, mya) of the last common ancestor of the host animals in which the polyomavirus pair was found. Apparent recent transmission of some Avi polyomaviruses between distantly related bird species is represented by points close to the x-axis. The absence of such points in the Almi and Ortho clades indicates a lack of evidence for recent transmission of polyomaviruses between distantly related mammal species. The arbitrary dashed reference line has a slope of about 0.5% polyomavirus divergence per million years after host divergence.

Mentions: The first known polyomavirus of birds was discovered in diseased budgerigar fledglings (reviewed in [43]). Sequences >99% identical to the original budgerigar fledgling disease polyomavirus have subsequently been found in a surprisingly wide range of distantly related bird species [44–47]. Likewise, sequences nearly identical to goose hemorrhagic polyomavirus have been found in ducks [48, 49](accession JF304775). These prior findings are displayed as points close to the x-axis in Fig 7. Although the findings indicate that the host-switching model shown in the middle panel of Fig 6 might be applicable to some avian polyomaviruses, an important caveat is that all documented instances of inter-species Avi polyomavirus transmission have involved captive animals. It thus remains uncertain whether Avi polyomavirus host-switching occurs in the wild over longer timescales.


The Ancient Evolutionary History of Polyomaviruses.

Buck CB, Van Doorslaer K, Peretti A, Geoghegan EM, Tisza MJ, An P, Katz JP, Pipas JM, McBride AA, Camus AC, McDermott AJ, Dill JA, Delwart E, Ng TF, Farkas K, Austin C, Kraberger S, Davison W, Pastrana DV, Varsani A - PLoS Pathog. (2016)

Virus-host co-divergence plot.SDT software was used to score individual pairs of polyomaviruses within various clades for percent divergence across the entire viral genome. The nucleotide divergence score was plotted against the estimated time (in millions of years ago, mya) of the last common ancestor of the host animals in which the polyomavirus pair was found. Apparent recent transmission of some Avi polyomaviruses between distantly related bird species is represented by points close to the x-axis. The absence of such points in the Almi and Ortho clades indicates a lack of evidence for recent transmission of polyomaviruses between distantly related mammal species. The arbitrary dashed reference line has a slope of about 0.5% polyomavirus divergence per million years after host divergence.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836724&req=5

ppat.1005574.g007: Virus-host co-divergence plot.SDT software was used to score individual pairs of polyomaviruses within various clades for percent divergence across the entire viral genome. The nucleotide divergence score was plotted against the estimated time (in millions of years ago, mya) of the last common ancestor of the host animals in which the polyomavirus pair was found. Apparent recent transmission of some Avi polyomaviruses between distantly related bird species is represented by points close to the x-axis. The absence of such points in the Almi and Ortho clades indicates a lack of evidence for recent transmission of polyomaviruses between distantly related mammal species. The arbitrary dashed reference line has a slope of about 0.5% polyomavirus divergence per million years after host divergence.
Mentions: The first known polyomavirus of birds was discovered in diseased budgerigar fledglings (reviewed in [43]). Sequences >99% identical to the original budgerigar fledgling disease polyomavirus have subsequently been found in a surprisingly wide range of distantly related bird species [44–47]. Likewise, sequences nearly identical to goose hemorrhagic polyomavirus have been found in ducks [48, 49](accession JF304775). These prior findings are displayed as points close to the x-axis in Fig 7. Although the findings indicate that the host-switching model shown in the middle panel of Fig 6 might be applicable to some avian polyomaviruses, an important caveat is that all documented instances of inter-species Avi polyomavirus transmission have involved captive animals. It thus remains uncertain whether Avi polyomavirus host-switching occurs in the wild over longer timescales.

Bottom Line: To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods.Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages.The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

View Article: PubMed Central - PubMed

Affiliation: Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.

ABSTRACT
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

Show MeSH
Related in: MedlinePlus