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Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

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Fig 9 Potential unanticipated consequences of high linoleic acid intake. A=increased consumption of vegetable oils rich in linoleic acid alters non-cholesterol lipid mediators, including hydroperoxy- and hydroxy-octadecadienoic acids, eicosanoids, and endocannabinoids; B=hydroperoxy- and hydroxy-octadecadienoic acids have been linked to coronary heart disease pathogenesis via mechanisms independent of traditional diet-heart hypothesis; non-cholesterol lipid mediators can also contribute to development of other common conditions including chronic pain and steatohepatitis
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f9: Fig 9 Potential unanticipated consequences of high linoleic acid intake. A=increased consumption of vegetable oils rich in linoleic acid alters non-cholesterol lipid mediators, including hydroperoxy- and hydroxy-octadecadienoic acids, eicosanoids, and endocannabinoids; B=hydroperoxy- and hydroxy-octadecadienoic acids have been linked to coronary heart disease pathogenesis via mechanisms independent of traditional diet-heart hypothesis; non-cholesterol lipid mediators can also contribute to development of other common conditions including chronic pain and steatohepatitis

Mentions: Increasing dietary linoleic acid has been shown to increase oxidized linoleic acid derivatives in a dose-dependent manner in many tissues.406263646566 These oxidized derivatives, along with other non-cholesterol lipid mediators, have been implicated in the pathogenesis of many diseases including coronary heart disease,14 chronic pain,40676869 and steatohepatitis707172(fig 9). While the biochemical and clinical consequences of high intakes are incompletely understood, there is a possibility for unintended harm. These potential risks highlight the importance of ensuring that the full evidence base from randomized controlled trials is available for consideration by scientists, policymakers, and the public.


Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Fig 9 Potential unanticipated consequences of high linoleic acid intake. A=increased consumption of vegetable oils rich in linoleic acid alters non-cholesterol lipid mediators, including hydroperoxy- and hydroxy-octadecadienoic acids, eicosanoids, and endocannabinoids; B=hydroperoxy- and hydroxy-octadecadienoic acids have been linked to coronary heart disease pathogenesis via mechanisms independent of traditional diet-heart hypothesis; non-cholesterol lipid mediators can also contribute to development of other common conditions including chronic pain and steatohepatitis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836695&req=5

f9: Fig 9 Potential unanticipated consequences of high linoleic acid intake. A=increased consumption of vegetable oils rich in linoleic acid alters non-cholesterol lipid mediators, including hydroperoxy- and hydroxy-octadecadienoic acids, eicosanoids, and endocannabinoids; B=hydroperoxy- and hydroxy-octadecadienoic acids have been linked to coronary heart disease pathogenesis via mechanisms independent of traditional diet-heart hypothesis; non-cholesterol lipid mediators can also contribute to development of other common conditions including chronic pain and steatohepatitis
Mentions: Increasing dietary linoleic acid has been shown to increase oxidized linoleic acid derivatives in a dose-dependent manner in many tissues.406263646566 These oxidized derivatives, along with other non-cholesterol lipid mediators, have been implicated in the pathogenesis of many diseases including coronary heart disease,14 chronic pain,40676869 and steatohepatitis707172(fig 9). While the biochemical and clinical consequences of high intakes are incompletely understood, there is a possibility for unintended harm. These potential risks highlight the importance of ensuring that the full evidence base from randomized controlled trials is available for consideration by scientists, policymakers, and the public.

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

Show MeSH
Related in: MedlinePlus