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Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

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Fig 4 MCE flow diagram. *16 825 participants completed MCE form No 011 (tape 4 data, appendix part 1); †Broste thesis reports that 9570 participants were randomized and that 147 dropped out prior to diet exposure, 1975 abstract and 1989 manuscript reported that 9449 and 9057 participants were randomized, respectively; ‡longitudinal serum cholesterol data recovered for 2355/2403 randomized participants exposed to diet for one year or more (tape 2 data, appendix part 1); ¶autopsy files with aortic and coronary atherosclerosis and infarct data recovered for 149/295 completed autopsies
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f4: Fig 4 MCE flow diagram. *16 825 participants completed MCE form No 011 (tape 4 data, appendix part 1); †Broste thesis reports that 9570 participants were randomized and that 147 dropped out prior to diet exposure, 1975 abstract and 1989 manuscript reported that 9449 and 9057 participants were randomized, respectively; ‡longitudinal serum cholesterol data recovered for 2355/2403 randomized participants exposed to diet for one year or more (tape 2 data, appendix part 1); ¶autopsy files with aortic and coronary atherosclerosis and infarct data recovered for 149/295 completed autopsies

Mentions: We were unable to recover the complete MCE dataset including all randomized participants. Thus, we could not conduct a traditional randomized controlled trial analysis to determine the effect of randomization. We do, however, include the life table graphs from the 1981 Broste thesis. A thorough explanation of methods and results can be found on pages 21-49 of the Broste thesis (http://www.psych.uic.edu/download/Broste_thesis_1981.pdf). For context, we include a CONSORT flow diagram (fig 4).


Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Fig 4 MCE flow diagram. *16 825 participants completed MCE form No 011 (tape 4 data, appendix part 1); †Broste thesis reports that 9570 participants were randomized and that 147 dropped out prior to diet exposure, 1975 abstract and 1989 manuscript reported that 9449 and 9057 participants were randomized, respectively; ‡longitudinal serum cholesterol data recovered for 2355/2403 randomized participants exposed to diet for one year or more (tape 2 data, appendix part 1); ¶autopsy files with aortic and coronary atherosclerosis and infarct data recovered for 149/295 completed autopsies
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836695&req=5

f4: Fig 4 MCE flow diagram. *16 825 participants completed MCE form No 011 (tape 4 data, appendix part 1); †Broste thesis reports that 9570 participants were randomized and that 147 dropped out prior to diet exposure, 1975 abstract and 1989 manuscript reported that 9449 and 9057 participants were randomized, respectively; ‡longitudinal serum cholesterol data recovered for 2355/2403 randomized participants exposed to diet for one year or more (tape 2 data, appendix part 1); ¶autopsy files with aortic and coronary atherosclerosis and infarct data recovered for 149/295 completed autopsies
Mentions: We were unable to recover the complete MCE dataset including all randomized participants. Thus, we could not conduct a traditional randomized controlled trial analysis to determine the effect of randomization. We do, however, include the life table graphs from the 1981 Broste thesis. A thorough explanation of methods and results can be found on pages 21-49 of the Broste thesis (http://www.psych.uic.edu/download/Broste_thesis_1981.pdf). For context, we include a CONSORT flow diagram (fig 4).

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

Show MeSH
Related in: MedlinePlus