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Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

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Fig 2 MCE total population and recovered cohorts (517 total deaths reported in 1989 publication by Frantz and colleagues15)
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f2: Fig 2 MCE total population and recovered cohorts (517 total deaths reported in 1989 publication by Frantz and colleagues15)

Mentions: We recovered raw MCE data, including previously unpublished records of serum cholesterol and autopsy reports (table 1 and fig 2), and an extensive collection of study documents, including a 1981 master’s thesis by S K Broste. The Broste thesis, which includes detailed survival analyses for the full randomized cohort and for the prespecified age and sex subgroups, has never previously been cited or considered part of the scientific evidence base (http://www.psych.uic.edu/download/Broste_thesis_1981.pdf).


Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR - BMJ (2016)

Fig 2 MCE total population and recovered cohorts (517 total deaths reported in 1989 publication by Frantz and colleagues15)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836695&req=5

f2: Fig 2 MCE total population and recovered cohorts (517 total deaths reported in 1989 publication by Frantz and colleagues15)
Mentions: We recovered raw MCE data, including previously unpublished records of serum cholesterol and autopsy reports (table 1 and fig 2), and an extensive collection of study documents, including a 1981 master’s thesis by S K Broste. The Broste thesis, which includes detailed survival analyses for the full randomized cohort and for the prespecified age and sex subgroups, has never previously been cited or considered part of the scientific evidence base (http://www.psych.uic.edu/download/Broste_thesis_1981.pdf).

Bottom Line: Control diet was high in saturated fat from animal fats, common margarines, and shortenings.Kaplan Meier graphs showed no mortality benefit for the intervention group in the full randomized cohort or for any prespecified subgroup.There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts.

View Article: PubMed Central - PubMed

Affiliation: Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina, Chapel Hill, NC, USA Chris.Ramsden@nih.gov.

Show MeSH
Related in: MedlinePlus