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Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus

The scatter plots for MPITDI and MPIConv according to the values of dP/dt max and dP/dt min, respectively.Depicting the scatter plots and the expected values for MPITDI and MPIConv according to the values of dP/dt max (Fig 3a) and dP/dt min (Fig 3b), respectively. Dotted curves indicate 95% confidence intervals. dP/dt max = the rate of LV pressure rise in early systole; dP/dt min = the rate of LV pressure decline in early diastole; MPITDI = Myocardial Performance Index by TDI M-mode; MPIConv = Myocardial Performance Index by the conventional method.
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pone.0153636.g003: The scatter plots for MPITDI and MPIConv according to the values of dP/dt max and dP/dt min, respectively.Depicting the scatter plots and the expected values for MPITDI and MPIConv according to the values of dP/dt max (Fig 3a) and dP/dt min (Fig 3b), respectively. Dotted curves indicate 95% confidence intervals. dP/dt max = the rate of LV pressure rise in early systole; dP/dt min = the rate of LV pressure decline in early diastole; MPITDI = Myocardial Performance Index by TDI M-mode; MPIConv = Myocardial Performance Index by the conventional method.

Mentions: The clinical characteristics of the validation cohort undergoing left heart catheterization are displayed in Table 3. There was no association between MPIConv and dP/dt max (p = 0.18; Table 4 and Fig 3a). The MPITDI decreased significantly with increasing values of dP/dt max (p = 0.047; Table 4 and Fig 3a), reflecting improved values of the combined cardiac index with improved cardiac contractility. In comparison, there was no association between dP/dt max and GLS (p = 0.20) or LVEF (p = 0.11). The only systolic echocardiographic parameter which displayed improved systolic function with better LV contractility determined by higher dP/dt max was GL Strainrate s (GL Strainrate s: β = -0.021 (-0.039 to -0.003), R2 = 0.12, p = 0.025, per 100 mmHg/sec increase).


Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

The scatter plots for MPITDI and MPIConv according to the values of dP/dt max and dP/dt min, respectively.Depicting the scatter plots and the expected values for MPITDI and MPIConv according to the values of dP/dt max (Fig 3a) and dP/dt min (Fig 3b), respectively. Dotted curves indicate 95% confidence intervals. dP/dt max = the rate of LV pressure rise in early systole; dP/dt min = the rate of LV pressure decline in early diastole; MPITDI = Myocardial Performance Index by TDI M-mode; MPIConv = Myocardial Performance Index by the conventional method.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836694&req=5

pone.0153636.g003: The scatter plots for MPITDI and MPIConv according to the values of dP/dt max and dP/dt min, respectively.Depicting the scatter plots and the expected values for MPITDI and MPIConv according to the values of dP/dt max (Fig 3a) and dP/dt min (Fig 3b), respectively. Dotted curves indicate 95% confidence intervals. dP/dt max = the rate of LV pressure rise in early systole; dP/dt min = the rate of LV pressure decline in early diastole; MPITDI = Myocardial Performance Index by TDI M-mode; MPIConv = Myocardial Performance Index by the conventional method.
Mentions: The clinical characteristics of the validation cohort undergoing left heart catheterization are displayed in Table 3. There was no association between MPIConv and dP/dt max (p = 0.18; Table 4 and Fig 3a). The MPITDI decreased significantly with increasing values of dP/dt max (p = 0.047; Table 4 and Fig 3a), reflecting improved values of the combined cardiac index with improved cardiac contractility. In comparison, there was no association between dP/dt max and GLS (p = 0.20) or LVEF (p = 0.11). The only systolic echocardiographic parameter which displayed improved systolic function with better LV contractility determined by higher dP/dt max was GL Strainrate s (GL Strainrate s: β = -0.021 (-0.039 to -0.003), R2 = 0.12, p = 0.025, per 100 mmHg/sec increase).

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus