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Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus

The expected cardiac time intervals according to age and gender in participants without cardiovascular disease or cardiovascular risk factors.Depicting the expected values of the cardiac time intervals with increasing age for participants stratified according to gender. Dotted curves indicate 95% confidence intervals. IVCT = Isovolumic Contraction Time; IVRT = Isovolumic Relaxation Time; ET = Ejection Time; MPI = Myocardial Performance Index.
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pone.0153636.g002: The expected cardiac time intervals according to age and gender in participants without cardiovascular disease or cardiovascular risk factors.Depicting the expected values of the cardiac time intervals with increasing age for participants stratified according to gender. Dotted curves indicate 95% confidence intervals. IVCT = Isovolumic Contraction Time; IVRT = Isovolumic Relaxation Time; ET = Ejection Time; MPI = Myocardial Performance Index.

Mentions: In participants without hypertension, diabetes, IHD, CHF or atrial fibrillation, normal values of cardiac time intervals were assessed. The population that contributed to the normal values consisted of 974 participants, 553 women and 421 men, (Table 1). The study participants were stratified according to age (20 to 39, 40 to 59, and ≥ 60 years) and gender (Table 2 and Fig 2).


Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

The expected cardiac time intervals according to age and gender in participants without cardiovascular disease or cardiovascular risk factors.Depicting the expected values of the cardiac time intervals with increasing age for participants stratified according to gender. Dotted curves indicate 95% confidence intervals. IVCT = Isovolumic Contraction Time; IVRT = Isovolumic Relaxation Time; ET = Ejection Time; MPI = Myocardial Performance Index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836694&req=5

pone.0153636.g002: The expected cardiac time intervals according to age and gender in participants without cardiovascular disease or cardiovascular risk factors.Depicting the expected values of the cardiac time intervals with increasing age for participants stratified according to gender. Dotted curves indicate 95% confidence intervals. IVCT = Isovolumic Contraction Time; IVRT = Isovolumic Relaxation Time; ET = Ejection Time; MPI = Myocardial Performance Index.
Mentions: In participants without hypertension, diabetes, IHD, CHF or atrial fibrillation, normal values of cardiac time intervals were assessed. The population that contributed to the normal values consisted of 974 participants, 553 women and 421 men, (Table 1). The study participants were stratified according to age (20 to 39, 40 to 59, and ≥ 60 years) and gender (Table 2 and Fig 2).

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus