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Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus

Cardiac time intervals assessed by a color tissue Doppler imaging (TDI) M-mode line through the mitral leaflet.Left: Four-chamber gray-scale (bottom) and color TDI (top) views in end-systole displaying the position of the M-mode line used for measuring the cardiac time intervals. Right: Color diagram of the TDI M-mode line through the mitral leaflet. MV = Mitral Valve; MVC = MV Closing; AVO = Aortic Valve Opening; AVC = Aortic Valve Closure; MVO = MV Opening.
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pone.0153636.g001: Cardiac time intervals assessed by a color tissue Doppler imaging (TDI) M-mode line through the mitral leaflet.Left: Four-chamber gray-scale (bottom) and color TDI (top) views in end-systole displaying the position of the M-mode line used for measuring the cardiac time intervals. Right: Color diagram of the TDI M-mode line through the mitral leaflet. MV = Mitral Valve; MVC = MV Closing; AVO = Aortic Valve Opening; AVC = Aortic Valve Closure; MVO = MV Opening.

Mentions: In both group A [8,18] and group B, cardiac time intervals were obtained by placing a 2–4 cm straight M-mode line through the septal half of the MV in the color TDI 4-chamber view and cardiac time intervals were measured directly from the color diagram[7,8,18] (Fig 1). The IVCT was defined as the time interval from MV closure (MVC), determined by the color shift from blue/turquoise to red at end-diastole, to aortic valve opening (AVO) determined by the color shift from blue to red (Fig 1). ET was defined as the time interval from AVO to aortic valve closing (AVC), determined by the color shift from red to blue at end systole (Fig 1). IVRT was defined as the time interval from AVC to MV opening (MVO), determined by the color shift from red-orange to yellow (Fig 1). The method has previously been validated [7,17,18], and has been demonstrated to be superior to the conventional method of obtaining cardiac time intervals[17,18]. Furthermore, we have previously demonstrated high reproducibility of the method in this present study population[18]. Both isovolumic time intervals were divided with ET creating IVRT/ET and IVCT/ET, respectively, and MPI was calculated as the sum of the two ((IVRT+IVCT)/ET).


Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

Biering-Sørensen T, Mogelvang R, de Knegt MC, Olsen FJ, Galatius S, Jensen JS - PLoS ONE (2016)

Cardiac time intervals assessed by a color tissue Doppler imaging (TDI) M-mode line through the mitral leaflet.Left: Four-chamber gray-scale (bottom) and color TDI (top) views in end-systole displaying the position of the M-mode line used for measuring the cardiac time intervals. Right: Color diagram of the TDI M-mode line through the mitral leaflet. MV = Mitral Valve; MVC = MV Closing; AVO = Aortic Valve Opening; AVC = Aortic Valve Closure; MVO = MV Opening.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836694&req=5

pone.0153636.g001: Cardiac time intervals assessed by a color tissue Doppler imaging (TDI) M-mode line through the mitral leaflet.Left: Four-chamber gray-scale (bottom) and color TDI (top) views in end-systole displaying the position of the M-mode line used for measuring the cardiac time intervals. Right: Color diagram of the TDI M-mode line through the mitral leaflet. MV = Mitral Valve; MVC = MV Closing; AVO = Aortic Valve Opening; AVC = Aortic Valve Closure; MVO = MV Opening.
Mentions: In both group A [8,18] and group B, cardiac time intervals were obtained by placing a 2–4 cm straight M-mode line through the septal half of the MV in the color TDI 4-chamber view and cardiac time intervals were measured directly from the color diagram[7,8,18] (Fig 1). The IVCT was defined as the time interval from MV closure (MVC), determined by the color shift from blue/turquoise to red at end-diastole, to aortic valve opening (AVO) determined by the color shift from blue to red (Fig 1). ET was defined as the time interval from AVO to aortic valve closing (AVC), determined by the color shift from red to blue at end systole (Fig 1). IVRT was defined as the time interval from AVC to MV opening (MVO), determined by the color shift from red-orange to yellow (Fig 1). The method has previously been validated [7,17,18], and has been demonstrated to be superior to the conventional method of obtaining cardiac time intervals[17,18]. Furthermore, we have previously demonstrated high reproducibility of the method in this present study population[18]. Both isovolumic time intervals were divided with ET creating IVRT/ET and IVCT/ET, respectively, and MPI was calculated as the sum of the two ((IVRT+IVCT)/ET).

Bottom Line: IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function.MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Purpose: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.

Methods: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET) were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT)/ET) were calculated. We also included a validation population (n = 44) of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.

Results: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all). IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max) and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s) and diastolic function (e', global strainrate e)(p<0.05 for all), whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all).

Conclusion: Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv) is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

No MeSH data available.


Related in: MedlinePlus