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Acoustic Characteristics of Stridor in Multiple System Atrophy.

Koo DL, Lee JY, Joo EY, Hong SB, Nam H - PLoS ONE (2016)

Bottom Line: Patients were then assessed clinically with sleep questionnaires, including the Pittsburgh Sleep Quality Index, and the Hoehn and Yahr scale.The rhythmic waveform group presented higher scores on the Hoehn and Yahr scale and the survival outcome of this group was lower compared to the semirhythmic waveform group (p = 0.030, p = 0.014).In the Kaplan Meier's survival curve, the outcome of patients with rhythmic waveform was significantly less favorable than the outcome of patients with semirhythmic waveform (log-rank test, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Seoul National University Boramae Hospital, Seoul, South Korea.

ABSTRACT
Nocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an increased risk of sudden death). In this study, we aimed to classify types of stridor by sound analysis and to reveal their clinical significance. Patients who met the criteria for probable MSA and had undergone polysomnography (PSG) were recruited. Patients were then assessed clinically with sleep questionnaires, including the Pittsburgh Sleep Quality Index, and the Hoehn and Yahr scale. Nocturnal stridor and snoring were analyzed with the Multi-Dimensional Voice Program. Nocturnal stridor was recorded in 22 patients and snoring in 18 patients using the PSG. Waveforms of stridors were classified into rhythmic or semirhythmic after analysis of the oscillogram. Formants and harmonics were observed in both types of stridor, but not in snoring. Of the 22 patients diagnosed with stridor during the present study, fifteen have subsequently died, with the time to death after the PSG study being 1.9 ± 1.4 years (range 0.8 to 5.0 years). The rhythmic waveform group presented higher scores on the Hoehn and Yahr scale and the survival outcome of this group was lower compared to the semirhythmic waveform group (p = 0.030, p = 0.014). In the Kaplan Meier's survival curve, the outcome of patients with rhythmic waveform was significantly less favorable than the outcome of patients with semirhythmic waveform (log-rank test, p < 0.001). Stridor in MSA can be classified into rhythmic and semirhythmic types and the rhythmic component signifies a poorer outcome.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier analysis of waveform-specific survival rate in patients with MSA stridor.Patients with rhythmic waveform (n = 9) have a significantly worse prognosis than those with semirhythmic waveform (n = 13) (Log rank test, p<0.001)
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pone.0153935.g002: Kaplan-Meier analysis of waveform-specific survival rate in patients with MSA stridor.Patients with rhythmic waveform (n = 9) have a significantly worse prognosis than those with semirhythmic waveform (n = 13) (Log rank test, p<0.001)

Mentions: Of the 22 patients with nocturnal stridor included in this study, 15 have subsequently died, with the time to death from the PSG being 1.7 ± 1.4 years (range 0.8 to 5.0 years). The seven survivors were followed up for 2.4 ± 1.4 years after the PSG. We applied correlation analysis between RBD and each type of stridor. There was no significant relationship between RBD and stridor subtypes (P = 0.131). Kaplan Meier’s survival analysis was applied to compare the survival after PSG between rhythmic and semirhythmic waveform groups. Patients with rhythmic waveform demonstrated a significantly more unfavorable outcome than those with semirhythmic waveform (log-rank test, p < 0.001) (Fig 2).


Acoustic Characteristics of Stridor in Multiple System Atrophy.

Koo DL, Lee JY, Joo EY, Hong SB, Nam H - PLoS ONE (2016)

Kaplan-Meier analysis of waveform-specific survival rate in patients with MSA stridor.Patients with rhythmic waveform (n = 9) have a significantly worse prognosis than those with semirhythmic waveform (n = 13) (Log rank test, p<0.001)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836672&req=5

pone.0153935.g002: Kaplan-Meier analysis of waveform-specific survival rate in patients with MSA stridor.Patients with rhythmic waveform (n = 9) have a significantly worse prognosis than those with semirhythmic waveform (n = 13) (Log rank test, p<0.001)
Mentions: Of the 22 patients with nocturnal stridor included in this study, 15 have subsequently died, with the time to death from the PSG being 1.7 ± 1.4 years (range 0.8 to 5.0 years). The seven survivors were followed up for 2.4 ± 1.4 years after the PSG. We applied correlation analysis between RBD and each type of stridor. There was no significant relationship between RBD and stridor subtypes (P = 0.131). Kaplan Meier’s survival analysis was applied to compare the survival after PSG between rhythmic and semirhythmic waveform groups. Patients with rhythmic waveform demonstrated a significantly more unfavorable outcome than those with semirhythmic waveform (log-rank test, p < 0.001) (Fig 2).

Bottom Line: Patients were then assessed clinically with sleep questionnaires, including the Pittsburgh Sleep Quality Index, and the Hoehn and Yahr scale.The rhythmic waveform group presented higher scores on the Hoehn and Yahr scale and the survival outcome of this group was lower compared to the semirhythmic waveform group (p = 0.030, p = 0.014).In the Kaplan Meier's survival curve, the outcome of patients with rhythmic waveform was significantly less favorable than the outcome of patients with semirhythmic waveform (log-rank test, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Seoul National University Boramae Hospital, Seoul, South Korea.

ABSTRACT
Nocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an increased risk of sudden death). In this study, we aimed to classify types of stridor by sound analysis and to reveal their clinical significance. Patients who met the criteria for probable MSA and had undergone polysomnography (PSG) were recruited. Patients were then assessed clinically with sleep questionnaires, including the Pittsburgh Sleep Quality Index, and the Hoehn and Yahr scale. Nocturnal stridor and snoring were analyzed with the Multi-Dimensional Voice Program. Nocturnal stridor was recorded in 22 patients and snoring in 18 patients using the PSG. Waveforms of stridors were classified into rhythmic or semirhythmic after analysis of the oscillogram. Formants and harmonics were observed in both types of stridor, but not in snoring. Of the 22 patients diagnosed with stridor during the present study, fifteen have subsequently died, with the time to death after the PSG study being 1.9 ± 1.4 years (range 0.8 to 5.0 years). The rhythmic waveform group presented higher scores on the Hoehn and Yahr scale and the survival outcome of this group was lower compared to the semirhythmic waveform group (p = 0.030, p = 0.014). In the Kaplan Meier's survival curve, the outcome of patients with rhythmic waveform was significantly less favorable than the outcome of patients with semirhythmic waveform (log-rank test, p < 0.001). Stridor in MSA can be classified into rhythmic and semirhythmic types and the rhythmic component signifies a poorer outcome.

No MeSH data available.


Related in: MedlinePlus