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A Unified Frequency Domain Model to Study the Effect of Demyelination on Axonal Conduction.

Chaubey S, Goodwin SJ - Biomed Eng Comput Biol (2016)

Bottom Line: The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach.Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled.Using this approach, future studies can model the loss of myelin in various parts of nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.

ABSTRACT
Multiple sclerosis is a disease caused by demyelination of nerve fibers. In order to determine the loss of signal with the percentage of demyelination, we need to develop models that can simulate this effect. Existing time-based models does not provide a method to determine the influences of demyelination based on simulation results. Our goal is to develop a system identification approach to generate a transfer function in the frequency domain. The idea is to create a unified modeling approach for neural action potential propagation along the length of an axon containing number of Nodes of Ranvier (N). A system identification approach has been used to identify a transfer function of the classical Hodgkin-Huxley equations for membrane voltage potential. Using this approach, we model cable properties and signal propagation along the length of the axon with N node myelination. MATLAB/Simulink platform is used to analyze an N node-myelinated neuronal axon. The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach. Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled. Using this approach, future studies can model the loss of myelin in various parts of nervous system.

No MeSH data available.


Related in: MedlinePlus

Simulated frequency response of a single chamber of a neuron variation of action potential velocity vs Node of Ranvier. (A) Magnitude and phase response and (B) transfer function and pole zero plot.
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f6-becb-7-2016-019: Simulated frequency response of a single chamber of a neuron variation of action potential velocity vs Node of Ranvier. (A) Magnitude and phase response and (B) transfer function and pole zero plot.

Mentions: Figure 6 illustrates the open loop characteristics of a single axon/dendrite chamber. As shown in Figure 6B, the transfer function has one zero and three poles. Also from Figure 6A, it can be seen that the phase margin is 33°, which guarantees the stability of the transfer function.


A Unified Frequency Domain Model to Study the Effect of Demyelination on Axonal Conduction.

Chaubey S, Goodwin SJ - Biomed Eng Comput Biol (2016)

Simulated frequency response of a single chamber of a neuron variation of action potential velocity vs Node of Ranvier. (A) Magnitude and phase response and (B) transfer function and pole zero plot.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4836623&req=5

f6-becb-7-2016-019: Simulated frequency response of a single chamber of a neuron variation of action potential velocity vs Node of Ranvier. (A) Magnitude and phase response and (B) transfer function and pole zero plot.
Mentions: Figure 6 illustrates the open loop characteristics of a single axon/dendrite chamber. As shown in Figure 6B, the transfer function has one zero and three poles. Also from Figure 6A, it can be seen that the phase margin is 33°, which guarantees the stability of the transfer function.

Bottom Line: The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach.Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled.Using this approach, future studies can model the loss of myelin in various parts of nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.

ABSTRACT
Multiple sclerosis is a disease caused by demyelination of nerve fibers. In order to determine the loss of signal with the percentage of demyelination, we need to develop models that can simulate this effect. Existing time-based models does not provide a method to determine the influences of demyelination based on simulation results. Our goal is to develop a system identification approach to generate a transfer function in the frequency domain. The idea is to create a unified modeling approach for neural action potential propagation along the length of an axon containing number of Nodes of Ranvier (N). A system identification approach has been used to identify a transfer function of the classical Hodgkin-Huxley equations for membrane voltage potential. Using this approach, we model cable properties and signal propagation along the length of the axon with N node myelination. MATLAB/Simulink platform is used to analyze an N node-myelinated neuronal axon. The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach. Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled. Using this approach, future studies can model the loss of myelin in various parts of nervous system.

No MeSH data available.


Related in: MedlinePlus