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A Unified Frequency Domain Model to Study the Effect of Demyelination on Axonal Conduction.

Chaubey S, Goodwin SJ - Biomed Eng Comput Biol (2016)

Bottom Line: The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach.Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled.Using this approach, future studies can model the loss of myelin in various parts of nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.

ABSTRACT
Multiple sclerosis is a disease caused by demyelination of nerve fibers. In order to determine the loss of signal with the percentage of demyelination, we need to develop models that can simulate this effect. Existing time-based models does not provide a method to determine the influences of demyelination based on simulation results. Our goal is to develop a system identification approach to generate a transfer function in the frequency domain. The idea is to create a unified modeling approach for neural action potential propagation along the length of an axon containing number of Nodes of Ranvier (N). A system identification approach has been used to identify a transfer function of the classical Hodgkin-Huxley equations for membrane voltage potential. Using this approach, we model cable properties and signal propagation along the length of the axon with N node myelination. MATLAB/Simulink platform is used to analyze an N node-myelinated neuronal axon. The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach. Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled. Using this approach, future studies can model the loss of myelin in various parts of nervous system.

No MeSH data available.


Related in: MedlinePlus

First-order response of a reduced form of Hodgkin–Huxley equation (as described in Equation 2). This shows the effect of neglecting the ion activation and inactivation channels. (A) Reduced circuit diagram of the single neuron chamber. (B) First order response with only leakage component into consideration.
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f3-becb-7-2016-019: First-order response of a reduced form of Hodgkin–Huxley equation (as described in Equation 2). This shows the effect of neglecting the ion activation and inactivation channels. (A) Reduced circuit diagram of the single neuron chamber. (B) First order response with only leakage component into consideration.

Mentions: Thus, this system is reduced to a first-order system with finite output response (Fig. 3). By the theory of control analysis,7 this result proves the existence of valid and stable transfer function (following our set of heuristic assumptions).


A Unified Frequency Domain Model to Study the Effect of Demyelination on Axonal Conduction.

Chaubey S, Goodwin SJ - Biomed Eng Comput Biol (2016)

First-order response of a reduced form of Hodgkin–Huxley equation (as described in Equation 2). This shows the effect of neglecting the ion activation and inactivation channels. (A) Reduced circuit diagram of the single neuron chamber. (B) First order response with only leakage component into consideration.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4836623&req=5

f3-becb-7-2016-019: First-order response of a reduced form of Hodgkin–Huxley equation (as described in Equation 2). This shows the effect of neglecting the ion activation and inactivation channels. (A) Reduced circuit diagram of the single neuron chamber. (B) First order response with only leakage component into consideration.
Mentions: Thus, this system is reduced to a first-order system with finite output response (Fig. 3). By the theory of control analysis,7 this result proves the existence of valid and stable transfer function (following our set of heuristic assumptions).

Bottom Line: The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach.Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled.Using this approach, future studies can model the loss of myelin in various parts of nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.

ABSTRACT
Multiple sclerosis is a disease caused by demyelination of nerve fibers. In order to determine the loss of signal with the percentage of demyelination, we need to develop models that can simulate this effect. Existing time-based models does not provide a method to determine the influences of demyelination based on simulation results. Our goal is to develop a system identification approach to generate a transfer function in the frequency domain. The idea is to create a unified modeling approach for neural action potential propagation along the length of an axon containing number of Nodes of Ranvier (N). A system identification approach has been used to identify a transfer function of the classical Hodgkin-Huxley equations for membrane voltage potential. Using this approach, we model cable properties and signal propagation along the length of the axon with N node myelination. MATLAB/Simulink platform is used to analyze an N node-myelinated neuronal axon. The ability to transfer function in the frequency domain will help reduce effort and will give a much more realistic feel when compared to the classical time-based approach. Once a transfer function is identified, the conduction as a cascade of each linear time invariant system-based transfer function can be modeled. Using this approach, future studies can model the loss of myelin in various parts of nervous system.

No MeSH data available.


Related in: MedlinePlus