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Quantification of the Effect of Pressure Wire Drift on the Diagnostic Performance of Fractional Flow Reserve, Instantaneous Wave-Free Ratio, and Whole-Cycle Pd/Pa.

Cook CM, Ahmad Y, Shun-Shin MJ, Nijjer S, Petraco R, Al-Lamee R, Mayet J, Francis DP, Sen S, Davies JE - Circ Cardiovasc Interv (2016)

Bottom Line: Both FFR and iFR had significantly lower misclassification than whole-cycle Pd/Pa (P<0.001).There was no statistically significant difference between the diagnostic performance of FFR and iFR (P=0.125).Whole-cycle Pd/Pa is more vulnerable to such reclassification than FFR and iFR.

View Article: PubMed Central - PubMed

Affiliation: From the International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College NHS Trust, United Kingdom. christopher.cook@nhs.net.

No MeSH data available.


Related in: MedlinePlus

Quantification of the effect of clinically tolerated degrees of pressure wire drift on the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle distal pressure/proximal pressure (Pd/Pa) in 447 stenoses; 21% (94), 25% (110), and 33% (148) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively. FFR and iFR were significantly more resilient to stenosis misclassification than whole-cycle Pd/Pa analysis. There was no statistically significant difference in the diagnostic performance of FFR and iFR.
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Figure 2: Quantification of the effect of clinically tolerated degrees of pressure wire drift on the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle distal pressure/proximal pressure (Pd/Pa) in 447 stenoses; 21% (94), 25% (110), and 33% (148) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively. FFR and iFR were significantly more resilient to stenosis misclassification than whole-cycle Pd/Pa analysis. There was no statistically significant difference in the diagnostic performance of FFR and iFR.

Mentions: Stenosis misclassification occurred with ±2 mm Hg pressure wire drift across all 3 indices and was commonest with whole-cycle Pd/Pa. Both FFR and iFR had significantly lower proportions of misclassification than whole-cycle Pd/Pa (P<0.001). There was no statistically significant difference between the diagnostic performance of FFR and iFR indices (P=0.125). Overall, 21% (94), 25% (110), and 33% (148) of the total study population were reclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively (Figure 2). The effect of aortic pressure drift was similar. Overall, 15% (68), 23% (101), and 31% (138) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively.


Quantification of the Effect of Pressure Wire Drift on the Diagnostic Performance of Fractional Flow Reserve, Instantaneous Wave-Free Ratio, and Whole-Cycle Pd/Pa.

Cook CM, Ahmad Y, Shun-Shin MJ, Nijjer S, Petraco R, Al-Lamee R, Mayet J, Francis DP, Sen S, Davies JE - Circ Cardiovasc Interv (2016)

Quantification of the effect of clinically tolerated degrees of pressure wire drift on the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle distal pressure/proximal pressure (Pd/Pa) in 447 stenoses; 21% (94), 25% (110), and 33% (148) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively. FFR and iFR were significantly more resilient to stenosis misclassification than whole-cycle Pd/Pa analysis. There was no statistically significant difference in the diagnostic performance of FFR and iFR.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836560&req=5

Figure 2: Quantification of the effect of clinically tolerated degrees of pressure wire drift on the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle distal pressure/proximal pressure (Pd/Pa) in 447 stenoses; 21% (94), 25% (110), and 33% (148) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively. FFR and iFR were significantly more resilient to stenosis misclassification than whole-cycle Pd/Pa analysis. There was no statistically significant difference in the diagnostic performance of FFR and iFR.
Mentions: Stenosis misclassification occurred with ±2 mm Hg pressure wire drift across all 3 indices and was commonest with whole-cycle Pd/Pa. Both FFR and iFR had significantly lower proportions of misclassification than whole-cycle Pd/Pa (P<0.001). There was no statistically significant difference between the diagnostic performance of FFR and iFR indices (P=0.125). Overall, 21% (94), 25% (110), and 33% (148) of the total study population were reclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively (Figure 2). The effect of aortic pressure drift was similar. Overall, 15% (68), 23% (101), and 31% (138) of the total study population were inappropriately misclassified with FFR, iFR, and whole-cycle Pd/Pa, respectively.

Bottom Line: Both FFR and iFR had significantly lower misclassification than whole-cycle Pd/Pa (P<0.001).There was no statistically significant difference between the diagnostic performance of FFR and iFR (P=0.125).Whole-cycle Pd/Pa is more vulnerable to such reclassification than FFR and iFR.

View Article: PubMed Central - PubMed

Affiliation: From the International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College NHS Trust, United Kingdom. christopher.cook@nhs.net.

No MeSH data available.


Related in: MedlinePlus