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Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice.

Hosick PA, AlAmodi AA, Hankins MW, Stec DE - Adipocyte (2015)

Bottom Line: Chronic treatment with CORM-A1 resulted in a 33% decrease from initial body weight over the 30 week treatment period while treatment with iCORM and saline were associated with 18 and 25% gain in initial body weight over the same time frame.Chronic treatment with CORM-A1 did not affect food intake or activity but resulted in a significant increase in metabolism.CORM-A1 treatment also resulted in lower fasting blood glucose, improvement in insulin sensitivity and decreased heptatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology & Biophysics; Center for Excellence in Cardiovascular-Renal Research; University of Mississippi Medical Center; Jackson, MS USA; Department of Exercise Science and Physical Education; Montclair State University; Montclair, NJ USA.

ABSTRACT
Chronic, low level treatment with a carbon monoxide releasing molecule (CO-RM), CORM-A1, has been shown to prevent the development of obesity in response to a high fat diet. The objective of this study was to test the hypothesis that chronic, low level treatment with this CO-RM can reverse established obesity via a mechanism independent of food intake. Dietary induced obese mice were treated with CORM-A1, the inactive compound iCORM-A1, or saline every 48 hours for 30 weeks while maintained on a high fat (60%) diet. Chronic treatment with CORM-A1 resulted in a 33% decrease from initial body weight over the 30 week treatment period while treatment with iCORM and saline were associated with 18 and 25% gain in initial body weight over the same time frame. Chronic treatment with CORM-A1 did not affect food intake or activity but resulted in a significant increase in metabolism. CORM-A1 treatment also resulted in lower fasting blood glucose, improvement in insulin sensitivity and decreased heptatic steatosis. Chronic treatment with CO releasing molecules can reverse dietary induced obesity and normalize insulin resistance independent of changes in food intake or activity. These findings are likely though a mechanism which increases metabolism.

No MeSH data available.


Related in: MedlinePlus

Body weights of treated mice over 30 week study. * = P < 0.05 as compared to other groups. † = P < 0.05 as compared to control and iCORM-A1 treated mice.
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f0001: Body weights of treated mice over 30 week study. * = P < 0.05 as compared to other groups. † = P < 0.05 as compared to control and iCORM-A1 treated mice.

Mentions: Initial body weights of 3 treatment groups were not different; however, the control mice were significantly lighter over the first 3 weeks of the experimental protocol but caught up to the iCORM-A1 and saline treated groups by 6 weeks of age (Fig. 1). CORM-A1 treatment resulted in the lack of weight gain in the high fat treated mice over the first 18 weeks of the study after which time the mice started to progressively lose weight over the last 12 weeks such that at the end of the experimental protocol the mice lost 33% of their initial body weight (Fig. 1). Saline treated mice transiently exhibited a greater increase in body weight during week's 19–21 of the study but no significant differences in body weight between controls, saline or iCORM-A1 treated mice were observed at the end of the study (Fig. 1).Figure 1.


Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice.

Hosick PA, AlAmodi AA, Hankins MW, Stec DE - Adipocyte (2015)

Body weights of treated mice over 30 week study. * = P < 0.05 as compared to other groups. † = P < 0.05 as compared to control and iCORM-A1 treated mice.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836479&req=5

f0001: Body weights of treated mice over 30 week study. * = P < 0.05 as compared to other groups. † = P < 0.05 as compared to control and iCORM-A1 treated mice.
Mentions: Initial body weights of 3 treatment groups were not different; however, the control mice were significantly lighter over the first 3 weeks of the experimental protocol but caught up to the iCORM-A1 and saline treated groups by 6 weeks of age (Fig. 1). CORM-A1 treatment resulted in the lack of weight gain in the high fat treated mice over the first 18 weeks of the study after which time the mice started to progressively lose weight over the last 12 weeks such that at the end of the experimental protocol the mice lost 33% of their initial body weight (Fig. 1). Saline treated mice transiently exhibited a greater increase in body weight during week's 19–21 of the study but no significant differences in body weight between controls, saline or iCORM-A1 treated mice were observed at the end of the study (Fig. 1).Figure 1.

Bottom Line: Chronic treatment with CORM-A1 resulted in a 33% decrease from initial body weight over the 30 week treatment period while treatment with iCORM and saline were associated with 18 and 25% gain in initial body weight over the same time frame.Chronic treatment with CORM-A1 did not affect food intake or activity but resulted in a significant increase in metabolism.CORM-A1 treatment also resulted in lower fasting blood glucose, improvement in insulin sensitivity and decreased heptatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology & Biophysics; Center for Excellence in Cardiovascular-Renal Research; University of Mississippi Medical Center; Jackson, MS USA; Department of Exercise Science and Physical Education; Montclair State University; Montclair, NJ USA.

ABSTRACT
Chronic, low level treatment with a carbon monoxide releasing molecule (CO-RM), CORM-A1, has been shown to prevent the development of obesity in response to a high fat diet. The objective of this study was to test the hypothesis that chronic, low level treatment with this CO-RM can reverse established obesity via a mechanism independent of food intake. Dietary induced obese mice were treated with CORM-A1, the inactive compound iCORM-A1, or saline every 48 hours for 30 weeks while maintained on a high fat (60%) diet. Chronic treatment with CORM-A1 resulted in a 33% decrease from initial body weight over the 30 week treatment period while treatment with iCORM and saline were associated with 18 and 25% gain in initial body weight over the same time frame. Chronic treatment with CORM-A1 did not affect food intake or activity but resulted in a significant increase in metabolism. CORM-A1 treatment also resulted in lower fasting blood glucose, improvement in insulin sensitivity and decreased heptatic steatosis. Chronic treatment with CO releasing molecules can reverse dietary induced obesity and normalize insulin resistance independent of changes in food intake or activity. These findings are likely though a mechanism which increases metabolism.

No MeSH data available.


Related in: MedlinePlus