Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response.
Bottom Line: Despite characterization of the host factors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate these SUMOylation events remain to be defined.Moreover, in the absence of ICP0, high-molecular-weight SUMO-conjugated proteins do not accumulate if HSV-1 DNA does not replicate.The protein inhibitor of activated STAT (PIAS) family of SUMO ligases is predominantly associated with the suppression of innate immune signaling.
Affiliation: MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland, United Kingdom.Show MeSH
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Mentions: To investigate the roles of PIAS4 during HSV-1 infection, the domains that mediate recruitment into replication compartments were evaluated (Fig. 3A). While the SAP domain regulates MAR association (65, 66), the LxxLL sequence, PINIT domain, SIM, or carboxyl (C)-terminal acidic domain (AD) may mediate important protein-protein interactions that regulate PIAS4 localization during infection (Fig. 3A). Additionally, the catalytic activity of PIAS4 may regulate localization through the SUMOylation of substrates to influence relevant protein-protein interactions.
Affiliation: MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland, United Kingdom.