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Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus

(a) The magnetization of pure Zr as function of applied magnetic field at room temperature and the corresponding linear fit, and (b) magnetic susceptibility variations of pure Zr and Zr–Ru alloys(⋆indicating p < 0.001 when comparing with pure Zr).
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f8: (a) The magnetization of pure Zr as function of applied magnetic field at room temperature and the corresponding linear fit, and (b) magnetic susceptibility variations of pure Zr and Zr–Ru alloys(⋆indicating p < 0.001 when comparing with pure Zr).

Mentions: The magnetization variation of pure Zr vs. the applied magnetic field at room temperature is shown in Fig. 8(a). Similar to pure Zr, the Zr–Ru alloys showed uniformly a linear variation relationship between magnetization and applied magnetic field, therefore the curves are omitted here. Instead, the magnetic susceptibilities of pure Zr and the Zr–Ru alloys, determined by the slope through linear fitting of the data, are plotted in Fig. 8 (b). It is obviously seen that after adding the alloying element Ru, the magnetic susceptibility significantly decreased. The mostly effective composition point lies in 1% Ru addition, with the magnetic susceptibility being the lowest, 1.247 × 10−6 cm3·g−1, indicating much better MRI compatibility compared with pure Zr (the magnetic susceptibility is 1.475 × 10−6 cm3·g−1).


Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

(a) The magnetization of pure Zr as function of applied magnetic field at room temperature and the corresponding linear fit, and (b) magnetic susceptibility variations of pure Zr and Zr–Ru alloys(⋆indicating p < 0.001 when comparing with pure Zr).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836298&req=5

f8: (a) The magnetization of pure Zr as function of applied magnetic field at room temperature and the corresponding linear fit, and (b) magnetic susceptibility variations of pure Zr and Zr–Ru alloys(⋆indicating p < 0.001 when comparing with pure Zr).
Mentions: The magnetization variation of pure Zr vs. the applied magnetic field at room temperature is shown in Fig. 8(a). Similar to pure Zr, the Zr–Ru alloys showed uniformly a linear variation relationship between magnetization and applied magnetic field, therefore the curves are omitted here. Instead, the magnetic susceptibilities of pure Zr and the Zr–Ru alloys, determined by the slope through linear fitting of the data, are plotted in Fig. 8 (b). It is obviously seen that after adding the alloying element Ru, the magnetic susceptibility significantly decreased. The mostly effective composition point lies in 1% Ru addition, with the magnetic susceptibility being the lowest, 1.247 × 10−6 cm3·g−1, indicating much better MRI compatibility compared with pure Zr (the magnetic susceptibility is 1.475 × 10−6 cm3·g−1).

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus