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Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus

Cell viabilities after culturing in pure Zr and Zr–Ru alloys’ extraction media for 1, 3 and 5 days: (a) L-929 cell line and (b) MG 63 cell line (⋆indicating p < 0.001 when comparing with negative control).
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f6: Cell viabilities after culturing in pure Zr and Zr–Ru alloys’ extraction media for 1, 3 and 5 days: (a) L-929 cell line and (b) MG 63 cell line (⋆indicating p < 0.001 when comparing with negative control).

Mentions: Figure 6 illustrates the L929 (Fig. 6(a)) and MG63 (Fig. 6(b)) proliferations after culturing in extraction media of pure Zr and Zr–Ru alloys for different time periods. It could be seen that, after 1, 3 and 5 days of culture, the cell viabilities of pure Zr and Zr–Ru alloys were almost the same as that of the negative group, and the statistic analysis indicated no significant difference among negative control, pure Zr and Zr–1Ru alloy groups (p > 0.05). Moreover, the cell morphology of the pure Zr and Zr–Ru alloy groups are similar to that of the negative control group, i.e. healthy, well spreading and stretching, spindle-shaped or cellular polygon-shaped, converging and laminipodia could be observed (Supplementary Information S5).


Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Cell viabilities after culturing in pure Zr and Zr–Ru alloys’ extraction media for 1, 3 and 5 days: (a) L-929 cell line and (b) MG 63 cell line (⋆indicating p < 0.001 when comparing with negative control).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836298&req=5

f6: Cell viabilities after culturing in pure Zr and Zr–Ru alloys’ extraction media for 1, 3 and 5 days: (a) L-929 cell line and (b) MG 63 cell line (⋆indicating p < 0.001 when comparing with negative control).
Mentions: Figure 6 illustrates the L929 (Fig. 6(a)) and MG63 (Fig. 6(b)) proliferations after culturing in extraction media of pure Zr and Zr–Ru alloys for different time periods. It could be seen that, after 1, 3 and 5 days of culture, the cell viabilities of pure Zr and Zr–Ru alloys were almost the same as that of the negative group, and the statistic analysis indicated no significant difference among negative control, pure Zr and Zr–1Ru alloy groups (p > 0.05). Moreover, the cell morphology of the pure Zr and Zr–Ru alloy groups are similar to that of the negative control group, i.e. healthy, well spreading and stretching, spindle-shaped or cellular polygon-shaped, converging and laminipodia could be observed (Supplementary Information S5).

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus