Limits...
Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus

Fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys: (a) pure Zr, (b) Zr–0.5Ru, (c) Zr–1Ru, (d) Zr–2Ru, (e) Zr–3Ru, (f) Zr–5Ru and (g) Zr–10Ru alloy samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4836298&req=5

f3: Fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys: (a) pure Zr, (b) Zr–0.5Ru, (c) Zr–1Ru, (d) Zr–2Ru, (e) Zr–3Ru, (f) Zr–5Ru and (g) Zr–10Ru alloy samples.

Mentions: Figure 3 showed the fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys. It is obvious that the fracture morphology characteristics consistent with the results of tensile experiments. For the as-cast groups, the fracture morphology of pure Zr, Zr–0.5Ru and Zr–1Ru exhibited typical toughness fracture, with many dimple patterns being observed. The dimples of the Zr–2Ru alloy are very small and shallow, indicating the decreased toughness. With the further increase of the content of Ru, the Zr–3Ru, Zr–5Ru and Zr–10Ru alloy exhibited typical cleavage fracture, indicating their relatively poor toughness. After annealing, all the Zr–Ru alloys exhibited typical toughness fracture, with many dimple patterns observed.


Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys: (a) pure Zr, (b) Zr–0.5Ru, (c) Zr–1Ru, (d) Zr–2Ru, (e) Zr–3Ru, (f) Zr–5Ru and (g) Zr–10Ru alloy samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836298&req=5

f3: Fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys: (a) pure Zr, (b) Zr–0.5Ru, (c) Zr–1Ru, (d) Zr–2Ru, (e) Zr–3Ru, (f) Zr–5Ru and (g) Zr–10Ru alloy samples.
Mentions: Figure 3 showed the fracture micrograph of as-cast (Fig. 3A) and annealed (Fig. 3B) pure Zr and Zr–Ru alloys. It is obvious that the fracture morphology characteristics consistent with the results of tensile experiments. For the as-cast groups, the fracture morphology of pure Zr, Zr–0.5Ru and Zr–1Ru exhibited typical toughness fracture, with many dimple patterns being observed. The dimples of the Zr–2Ru alloy are very small and shallow, indicating the decreased toughness. With the further increase of the content of Ru, the Zr–3Ru, Zr–5Ru and Zr–10Ru alloy exhibited typical cleavage fracture, indicating their relatively poor toughness. After annealing, all the Zr–Ru alloys exhibited typical toughness fracture, with many dimple patterns observed.

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus