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Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus

The tensile stress-strain curves (a,c) and tensile mechanical property data (b,d) of as-cast (a,b) and annealed (c,d) pure Zr and Zr–Ru alloys (*indicating p < 0.05, #indicating p < 0.01 and ⋆indicating p < 0.001 when comparing with pure Zr).
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f2: The tensile stress-strain curves (a,c) and tensile mechanical property data (b,d) of as-cast (a,b) and annealed (c,d) pure Zr and Zr–Ru alloys (*indicating p < 0.05, #indicating p < 0.01 and ⋆indicating p < 0.001 when comparing with pure Zr).

Mentions: The tensile stress-strain curves (a, c) and tensile mechanical property data (b, d) of as-cast (a, b) and annealed (c, d) pure Zr and Zr–Ru alloys are shown in Fig. 2. It can be seen that both the Yield Strength (YS) and the Ultimate Tensile Strength (UTS) of the Zr–Ru alloys are higher than that of pure Zr, except for the as-cast Zr–10Ru alloy, of which the UTS is slightly lower than that of the as-cast pure Zr, as the as-cast Zr–10Ru alloy exhibited brittle fracture during tensile test with the lowest elongation of 1.4%. After recrystallization annealing, pure Zr and Zr–Ru alloys exhibited higher ductility, as their average elongation at fracture exceeded 10%.


Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

The tensile stress-strain curves (a,c) and tensile mechanical property data (b,d) of as-cast (a,b) and annealed (c,d) pure Zr and Zr–Ru alloys (*indicating p < 0.05, #indicating p < 0.01 and ⋆indicating p < 0.001 when comparing with pure Zr).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836298&req=5

f2: The tensile stress-strain curves (a,c) and tensile mechanical property data (b,d) of as-cast (a,b) and annealed (c,d) pure Zr and Zr–Ru alloys (*indicating p < 0.05, #indicating p < 0.01 and ⋆indicating p < 0.001 when comparing with pure Zr).
Mentions: The tensile stress-strain curves (a, c) and tensile mechanical property data (b, d) of as-cast (a, b) and annealed (c, d) pure Zr and Zr–Ru alloys are shown in Fig. 2. It can be seen that both the Yield Strength (YS) and the Ultimate Tensile Strength (UTS) of the Zr–Ru alloys are higher than that of pure Zr, except for the as-cast Zr–10Ru alloy, of which the UTS is slightly lower than that of the as-cast pure Zr, as the as-cast Zr–10Ru alloy exhibited brittle fracture during tensile test with the lowest elongation of 1.4%. After recrystallization annealing, pure Zr and Zr–Ru alloys exhibited higher ductility, as their average elongation at fracture exceeded 10%.

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus