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Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus

XRD patterns of as-cast (a,b) and annealed (c,d) Zr–Ru alloys, (b,d) are the corresponding enlarged views of (a,c) in the range of 30°~40°.
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f1: XRD patterns of as-cast (a,b) and annealed (c,d) Zr–Ru alloys, (b,d) are the corresponding enlarged views of (a,c) in the range of 30°~40°.

Mentions: Figure 1 shows the XRD patterns of as-cast (Fig. 1(a,b)) and annealed (Fig. 1(c,d)) Zr–Ru alloys. For the as-cast Zr–Ru binary alloys, it can be seen from Fig. 1 that similar to pure zirconium, the Zr–0.5Ru, Zr–1Ru and Zr–2Ru alloys exhibited a single hexagonal close-packed structure (α phase). With the increase of the Ru content, the ω and β phases appeared in the XRD patterns of Zr–3Ru, Zr–5Ru and Zr–10Ru alloys. In addition, the RuZr phase was observed in Zr–10Ru alloy. After being cold worked to 50% thickness reduction and subsequently annealed at 600 °C, recrystallization occurred in the Zr–Ru alloys, as indicated by the reappearance of the α phase and the disappearance of the metastable ω phase in the Zr–3Ru and Zr–5Ru alloys.


Design and development of novel MRI compatible zirconium- ruthenium alloys with ultralow magnetic susceptibility.

Li HF, Zhou FY, Li L, Zheng YF - Sci Rep (2016)

XRD patterns of as-cast (a,b) and annealed (c,d) Zr–Ru alloys, (b,d) are the corresponding enlarged views of (a,c) in the range of 30°~40°.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836298&req=5

f1: XRD patterns of as-cast (a,b) and annealed (c,d) Zr–Ru alloys, (b,d) are the corresponding enlarged views of (a,c) in the range of 30°~40°.
Mentions: Figure 1 shows the XRD patterns of as-cast (Fig. 1(a,b)) and annealed (Fig. 1(c,d)) Zr–Ru alloys. For the as-cast Zr–Ru binary alloys, it can be seen from Fig. 1 that similar to pure zirconium, the Zr–0.5Ru, Zr–1Ru and Zr–2Ru alloys exhibited a single hexagonal close-packed structure (α phase). With the increase of the Ru content, the ω and β phases appeared in the XRD patterns of Zr–3Ru, Zr–5Ru and Zr–10Ru alloys. In addition, the RuZr phase was observed in Zr–10Ru alloy. After being cold worked to 50% thickness reduction and subsequently annealed at 600 °C, recrystallization occurred in the Zr–Ru alloys, as indicated by the reappearance of the α phase and the disappearance of the metastable ω phase in the Zr–3Ru and Zr–5Ru alloys.

Bottom Line: The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties.The corrosion resistance of zirconium-ruthenium alloys increased significantly.Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)).

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.

ABSTRACT
In the present study, novel MRI compatible zirconium-ruthenium alloys with ultralow magnetic susceptibility were developed for biomedical and therapeutic devices under MRI diagnostics environments. The results demonstrated that alloying with ruthenium into pure zirconium would significantly increase the strength and hardness properties. The corrosion resistance of zirconium-ruthenium alloys increased significantly. High cell viability could be found and healthy cell morphology observed when culturing MG 63 osteoblast-like cells and L-929 fibroblast cells with zirconium-ruthenium alloys, whereas the hemolysis rates of zirconium-ruthenium alloys are <1%, much lower than 5%, the safe value for biomaterials according to ISO 10993-4 standard. Compared with conventional biomedical 316L stainless steel, Co-Cr alloys and Ti-based alloys, the magnetic susceptibilities of the zirconium-ruthenium alloys (1.25 × 10(-6) cm(3)·g(-1)-1.29 × 10(-6) cm(3)·g(-1) for zirconium-ruthenium alloys) are ultralow, about one-third that of Ti-based alloys (Ti-6Al-4V, ~3.5 × 10(-6) cm(3)·g(-1), CP Ti and Ti-6Al-7Nb, ~3.0 × 10(-6) cm(3)·g(-1)), and one-sixth that of Co-Cr alloys (Co-Cr-Mo, ~7.7 × 10(-6) cm(3)·g(-1)). Among the Zr-Ru alloy series, Zr-1Ru demonstrates enhanced mechanical properties, excellent corrosion resistance and cell viability with lowest magnetic susceptibility, and thus is the optimal Zr-Ru alloy system as therapeutic devices under MRI diagnostics environments.

No MeSH data available.


Related in: MedlinePlus