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The history of pulse therapy in lupus nephritis (1976-2016).

Scheinberg M - Lupus Sci Med (2016)

Bottom Line: Pulse therapy with methylprednisolone became standard of care for the treatment of worsening lupus nephritis since its introduction in 1976.Even today, 40 years since its introduction, it is still a gold standard for this clinical condition.In this communication, we have reviewed the events that surrounded the use of this therapy by one of the authors of the original paper published in Lancet 40 years ago.

View Article: PubMed Central - PubMed

Affiliation: HospitalAlbert Einstein, Sao Paulo, Brazil; HospitalAACD, UK.

ABSTRACT
Pulse therapy with methylprednisolone became standard of care for the treatment of worsening lupus nephritis since its introduction in 1976. Even today, 40 years since its introduction, it is still a gold standard for this clinical condition. In this communication, we have reviewed the events that surrounded the use of this therapy by one of the authors of the original paper published in Lancet 40 years ago.

No MeSH data available.


Related in: MedlinePlus

Publication of the first paper on systemic lupus erythematosus nephritis.
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LUPUS2016000149F1: Publication of the first paper on systemic lupus erythematosus nephritis.

Mentions: The initial experience was confirmed by other groups and was extended to other clinical manifestations of active lupus and autoimmune diseases requiring acute immunosuppression with extensive citation throughout the last 40 years (table 1). Since the publication of the original paper in 1976, bolus injections of steroids have suffered considerable variation in the dose, number, timing and duration of the higher dose. Despite 40 years of use, the clarity of the mechanism of action is still, to some extent, unknown. It is well known that pulse therapy is cumulatively less toxic than treatment with continuous oral steroids at lower doses. However, it is also known that pulse therapy may be associated with side effects and contraindicated in systemic infections and uncontrolled hypertension and its use can lead to metabolic disturbances, and changes in behaviour, requiring adequate monitoring during its use (figures 1 and 2).


The history of pulse therapy in lupus nephritis (1976-2016).

Scheinberg M - Lupus Sci Med (2016)

Publication of the first paper on systemic lupus erythematosus nephritis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836283&req=5

LUPUS2016000149F1: Publication of the first paper on systemic lupus erythematosus nephritis.
Mentions: The initial experience was confirmed by other groups and was extended to other clinical manifestations of active lupus and autoimmune diseases requiring acute immunosuppression with extensive citation throughout the last 40 years (table 1). Since the publication of the original paper in 1976, bolus injections of steroids have suffered considerable variation in the dose, number, timing and duration of the higher dose. Despite 40 years of use, the clarity of the mechanism of action is still, to some extent, unknown. It is well known that pulse therapy is cumulatively less toxic than treatment with continuous oral steroids at lower doses. However, it is also known that pulse therapy may be associated with side effects and contraindicated in systemic infections and uncontrolled hypertension and its use can lead to metabolic disturbances, and changes in behaviour, requiring adequate monitoring during its use (figures 1 and 2).

Bottom Line: Pulse therapy with methylprednisolone became standard of care for the treatment of worsening lupus nephritis since its introduction in 1976.Even today, 40 years since its introduction, it is still a gold standard for this clinical condition.In this communication, we have reviewed the events that surrounded the use of this therapy by one of the authors of the original paper published in Lancet 40 years ago.

View Article: PubMed Central - PubMed

Affiliation: HospitalAlbert Einstein, Sao Paulo, Brazil; HospitalAACD, UK.

ABSTRACT
Pulse therapy with methylprednisolone became standard of care for the treatment of worsening lupus nephritis since its introduction in 1976. Even today, 40 years since its introduction, it is still a gold standard for this clinical condition. In this communication, we have reviewed the events that surrounded the use of this therapy by one of the authors of the original paper published in Lancet 40 years ago.

No MeSH data available.


Related in: MedlinePlus