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Clinicopathological study of sporadic Burkitt lymphoma in children.

Huang H, Liu ZL, Zeng H, Zhang SH, Huang CS, Xu HY, Wu Y, Zeng ST, Xiong F, Yang WP - Chin. Med. J. (2015)

Bottom Line: Polypoid BL showed a lower clinical stage (P = 0.002), and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome (P = 0.024 and 0.053, respectively).The anatomical location, growth pattern and serum albumin level of BL were associated with biological behavior.MUM1 may be a potential adverse prognostic marker, and not associated with EBV infection status.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jiangxi Children's Hospital, Nanchang, Jiangxi 330006, China.

ABSTRACT

Background: Non-Hodgkin lymphoma is the fourth most common malignant tumors in children, Burkitt lymphoma (BL) accounts for 30-50% of all pediatric lymphomas. The aim of this study was to investigate the clinicopathologic features, immunophenotype, Epstein-Barr virus (EBV) infection and c-myc gene rearrangement of sporadic BL in children.

Methods: Ninety-two cases of pediatric BL were retrospectively analyzed for clinical features, immunohistochemistry, EBV-encoded RNA (EBER) status by in situ hybridization and c-myc gene rearrangement by fluorescence in situ hybridization.

Results: In the 92 cases, male is predominant in sex distribution (M: F = 3.38:1). The average age at diagnosis was 4.97 years. Polypoid BL showed a lower clinical stage (P = 0.002), and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome (P = 0.024 and 0.053, respectively). The positive expression of CDl0, B-cell lymphoma-6, MUMl and EBER were 95.7% (88 cases), 92.4% (85 cases), 22.8% (21 cases), 41.3% (38 cases), respectively. The expression of MUM1 were not associated with EBV infection status (P = 1.000). c-myc gene rearrangement was detected in 94.6% (87/92). Clinical treatment information for 54 cases was collected, 21 patients died of tumor after surgery alone, 33 patients received surgery and chemotherapy, and of which six patients died shortly afterwords (MUM1 positive expression in 3 cases, P = 0.076).

Conclusions: The anatomical location, growth pattern and serum albumin level of BL were associated with biological behavior. MUM1 may be a potential adverse prognostic marker, and not associated with EBV infection status.

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Survival curves of 33 treated patients showed nearly statistical significance between MUM1 expression and prognosis (P = 0.076).
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Figure 5: Survival curves of 33 treated patients showed nearly statistical significance between MUM1 expression and prognosis (P = 0.076).

Mentions: Clinical treatment information was assessment for 54 of 92 cases, the follow-up time ranging from 2 days to 120 months. Among the 54 cases, 21 patients received surgery alone, all patients died of tumor (the average survival time was 5.2 months, ranging from 2 days to 20 months). Totally, 33 patients received surgery and chemotherapy ([R] CHOP-like regimen and NHL-[BFM]-90 regimen), six patients died of tumor and associated disease (including four bone marrow relapse cases, one respiratory failure case and one acute tumor lysis syndrome case) with the average survival time 9.7 months (ranging from 4 to 18 months), 27 was still alive with the average survival time 63.4 months (ranging from 8 to 120 months), including nine polypoid cases and one Stage II case without timely treatment. For the 33 patients received surgery and chemotherapy, advanced clinical stages were correlated to the poorer survival of BL (P = 0.024). MUM1 positive expression in 3 of 6 died cases [Figure 5] (P = 0.076).


Clinicopathological study of sporadic Burkitt lymphoma in children.

Huang H, Liu ZL, Zeng H, Zhang SH, Huang CS, Xu HY, Wu Y, Zeng ST, Xiong F, Yang WP - Chin. Med. J. (2015)

Survival curves of 33 treated patients showed nearly statistical significance between MUM1 expression and prognosis (P = 0.076).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836256&req=5

Figure 5: Survival curves of 33 treated patients showed nearly statistical significance between MUM1 expression and prognosis (P = 0.076).
Mentions: Clinical treatment information was assessment for 54 of 92 cases, the follow-up time ranging from 2 days to 120 months. Among the 54 cases, 21 patients received surgery alone, all patients died of tumor (the average survival time was 5.2 months, ranging from 2 days to 20 months). Totally, 33 patients received surgery and chemotherapy ([R] CHOP-like regimen and NHL-[BFM]-90 regimen), six patients died of tumor and associated disease (including four bone marrow relapse cases, one respiratory failure case and one acute tumor lysis syndrome case) with the average survival time 9.7 months (ranging from 4 to 18 months), 27 was still alive with the average survival time 63.4 months (ranging from 8 to 120 months), including nine polypoid cases and one Stage II case without timely treatment. For the 33 patients received surgery and chemotherapy, advanced clinical stages were correlated to the poorer survival of BL (P = 0.024). MUM1 positive expression in 3 of 6 died cases [Figure 5] (P = 0.076).

Bottom Line: Polypoid BL showed a lower clinical stage (P = 0.002), and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome (P = 0.024 and 0.053, respectively).The anatomical location, growth pattern and serum albumin level of BL were associated with biological behavior.MUM1 may be a potential adverse prognostic marker, and not associated with EBV infection status.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jiangxi Children's Hospital, Nanchang, Jiangxi 330006, China.

ABSTRACT

Background: Non-Hodgkin lymphoma is the fourth most common malignant tumors in children, Burkitt lymphoma (BL) accounts for 30-50% of all pediatric lymphomas. The aim of this study was to investigate the clinicopathologic features, immunophenotype, Epstein-Barr virus (EBV) infection and c-myc gene rearrangement of sporadic BL in children.

Methods: Ninety-two cases of pediatric BL were retrospectively analyzed for clinical features, immunohistochemistry, EBV-encoded RNA (EBER) status by in situ hybridization and c-myc gene rearrangement by fluorescence in situ hybridization.

Results: In the 92 cases, male is predominant in sex distribution (M: F = 3.38:1). The average age at diagnosis was 4.97 years. Polypoid BL showed a lower clinical stage (P = 0.002), and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome (P = 0.024 and 0.053, respectively). The positive expression of CDl0, B-cell lymphoma-6, MUMl and EBER were 95.7% (88 cases), 92.4% (85 cases), 22.8% (21 cases), 41.3% (38 cases), respectively. The expression of MUM1 were not associated with EBV infection status (P = 1.000). c-myc gene rearrangement was detected in 94.6% (87/92). Clinical treatment information for 54 cases was collected, 21 patients died of tumor after surgery alone, 33 patients received surgery and chemotherapy, and of which six patients died shortly afterwords (MUM1 positive expression in 3 cases, P = 0.076).

Conclusions: The anatomical location, growth pattern and serum albumin level of BL were associated with biological behavior. MUM1 may be a potential adverse prognostic marker, and not associated with EBV infection status.

Show MeSH
Related in: MedlinePlus