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Memory dysfunction in type 2 diabetes mellitus correlates with reduced hippocampal CA1 and subiculum volumes.

Zhang YW, Zhang JQ, Liu C, Wei P, Zhang X, Yuan QY, Yin XT, Wei LQ, Cui JG, Wang J - Chin. Med. J. (2015)

Bottom Line: Additionally, higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM.These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction, suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

ABSTRACT

Background: Little attention has been paid to the role of subcortical deep gray matter (SDGM) structures in type 2 diabetes mellitus (T2DM)-induced cognitive impairment, especially hippocampal subfields. Our aims were to assess the in vivo volumes of SDGM structures and hippocampal subfields using magnetic resonance imaging (MRI) and to test their associations with cognitive performance in T2DM.

Methods: A total of 80 T2DM patients and 80 neurologically unimpaired healthy controls matched by age, sex and education level was enrolled in this study. We assessed the volumes of the SDGM structures and seven hippocampal subfields on MRI using a novel technique that enabled automated volumetry. We used Mini-Mental State Examination and Montreal Cognitive Assessment (MoCA) scores as measures of cognitive performance. The association of glycosylated hemoglobin (HbA1c) with SDGM structures and neuropsychological tests and correlations between hippocampal subfields and neuropsychological tests were assessed by partial correlation analysis in T2DM.

Results: Bilaterally, the hippocampal volumes were smaller in T2DM patients, mainly in the CA1 and subiculum subfields. Partial correlation analysis showed that the MoCA scores, particularly those regarding delayed memory, were significantly positively correlated with reduced hippocampal CA1 and subiculum volumes in T2DM patients. Additionally, higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.

Conclusions: These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM. These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction, suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.

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The correlation of the bilateral CA1 volume (a) and the bilateral subiculum volume (b) with the total Montreal Cognitive Assessment (MoCA) score in T2DM patients. The correlation of the bilateral CA1 volume (c) and the bilateral subiculum volume (d) with the delayed recall score in T2DM patients. The error bar represents the 95% confidence interval.
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Figure 1: The correlation of the bilateral CA1 volume (a) and the bilateral subiculum volume (b) with the total Montreal Cognitive Assessment (MoCA) score in T2DM patients. The correlation of the bilateral CA1 volume (c) and the bilateral subiculum volume (d) with the delayed recall score in T2DM patients. The error bar represents the 95% confidence interval.

Mentions: Partial correlation analysis revealed that the total volumes of the CA1 and subiculum subfields were positively correlated with the total MoCA score (r = 0.516, P < 0.001, [Figure 1a]; r = 0.307, P = 0.007, [Figure 1b]), mainly in terms of delayed recall (r = 0.430, P < 0.001, [Figure 1c]; r = 0.385, P = 0.001; [Figure 1d]) in the T2DM patients.


Memory dysfunction in type 2 diabetes mellitus correlates with reduced hippocampal CA1 and subiculum volumes.

Zhang YW, Zhang JQ, Liu C, Wei P, Zhang X, Yuan QY, Yin XT, Wei LQ, Cui JG, Wang J - Chin. Med. J. (2015)

The correlation of the bilateral CA1 volume (a) and the bilateral subiculum volume (b) with the total Montreal Cognitive Assessment (MoCA) score in T2DM patients. The correlation of the bilateral CA1 volume (c) and the bilateral subiculum volume (d) with the delayed recall score in T2DM patients. The error bar represents the 95% confidence interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836248&req=5

Figure 1: The correlation of the bilateral CA1 volume (a) and the bilateral subiculum volume (b) with the total Montreal Cognitive Assessment (MoCA) score in T2DM patients. The correlation of the bilateral CA1 volume (c) and the bilateral subiculum volume (d) with the delayed recall score in T2DM patients. The error bar represents the 95% confidence interval.
Mentions: Partial correlation analysis revealed that the total volumes of the CA1 and subiculum subfields were positively correlated with the total MoCA score (r = 0.516, P < 0.001, [Figure 1a]; r = 0.307, P = 0.007, [Figure 1b]), mainly in terms of delayed recall (r = 0.430, P < 0.001, [Figure 1c]; r = 0.385, P = 0.001; [Figure 1d]) in the T2DM patients.

Bottom Line: Additionally, higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM.These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction, suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

ABSTRACT

Background: Little attention has been paid to the role of subcortical deep gray matter (SDGM) structures in type 2 diabetes mellitus (T2DM)-induced cognitive impairment, especially hippocampal subfields. Our aims were to assess the in vivo volumes of SDGM structures and hippocampal subfields using magnetic resonance imaging (MRI) and to test their associations with cognitive performance in T2DM.

Methods: A total of 80 T2DM patients and 80 neurologically unimpaired healthy controls matched by age, sex and education level was enrolled in this study. We assessed the volumes of the SDGM structures and seven hippocampal subfields on MRI using a novel technique that enabled automated volumetry. We used Mini-Mental State Examination and Montreal Cognitive Assessment (MoCA) scores as measures of cognitive performance. The association of glycosylated hemoglobin (HbA1c) with SDGM structures and neuropsychological tests and correlations between hippocampal subfields and neuropsychological tests were assessed by partial correlation analysis in T2DM.

Results: Bilaterally, the hippocampal volumes were smaller in T2DM patients, mainly in the CA1 and subiculum subfields. Partial correlation analysis showed that the MoCA scores, particularly those regarding delayed memory, were significantly positively correlated with reduced hippocampal CA1 and subiculum volumes in T2DM patients. Additionally, higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.

Conclusions: These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM. These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction, suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.

Show MeSH
Related in: MedlinePlus