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Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.

Iranpour M, Moghadam AR, Yazdi M, Ande SR, Alizadeh J, Wiechec E, Lindsay R, Drebot M, Coombs KM, Ghavami S - Expert Rev Mol Med (2016)

Bottom Line: Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern.The arbovirus infection and replication processes are complex, and many factors are involved in their regulation.In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes.

View Article: PubMed Central - PubMed

Affiliation: Zoonotic Diseases and Special Pathogens,National Microbiology Laboratory,Public Health Agency of Canada,1015 Arlington St.,Winnipeg,Manitoba,Canada.

ABSTRACT
Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.

No MeSH data available.


Related in: MedlinePlus

Global distribution of some of the most important arboviruses. (A) DENV, Dengue virus (Refs 41, 42), (B) YFV, Yellow fever (Refs 43, 44), (C) WNV, West Nile virus (Refs 45, 46, 47), (D) CHIKV, Chikungunya virus (Refs 47, 48), (E) JEV, Japanese encephalitis virus (Ref. 49), (F) VEEV, Venezuelan equine encephalitis virus (Ref. 47), (G) RVFV, Rift valley fever virus (Ref. 50), (H) CCHF, Crimean–Congo haemorrhagic fever (Ref. 51).
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fig02: Global distribution of some of the most important arboviruses. (A) DENV, Dengue virus (Refs 41, 42), (B) YFV, Yellow fever (Refs 43, 44), (C) WNV, West Nile virus (Refs 45, 46, 47), (D) CHIKV, Chikungunya virus (Refs 47, 48), (E) JEV, Japanese encephalitis virus (Ref. 49), (F) VEEV, Venezuelan equine encephalitis virus (Ref. 47), (G) RVFV, Rift valley fever virus (Ref. 50), (H) CCHF, Crimean–Congo haemorrhagic fever (Ref. 51).

Mentions: From a public health point of view, those arboviruses that produce viremia in humans and cause major mosquito-borne epidemics are most important (Ref. 40). Figure 2 shows world geographical distribution of the most important vector-born arboviruses. In the following section we will discuss some of the most common arbovirus-induced diseases.Figure 2.


Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.

Iranpour M, Moghadam AR, Yazdi M, Ande SR, Alizadeh J, Wiechec E, Lindsay R, Drebot M, Coombs KM, Ghavami S - Expert Rev Mol Med (2016)

Global distribution of some of the most important arboviruses. (A) DENV, Dengue virus (Refs 41, 42), (B) YFV, Yellow fever (Refs 43, 44), (C) WNV, West Nile virus (Refs 45, 46, 47), (D) CHIKV, Chikungunya virus (Refs 47, 48), (E) JEV, Japanese encephalitis virus (Ref. 49), (F) VEEV, Venezuelan equine encephalitis virus (Ref. 47), (G) RVFV, Rift valley fever virus (Ref. 50), (H) CCHF, Crimean–Congo haemorrhagic fever (Ref. 51).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836210&req=5

fig02: Global distribution of some of the most important arboviruses. (A) DENV, Dengue virus (Refs 41, 42), (B) YFV, Yellow fever (Refs 43, 44), (C) WNV, West Nile virus (Refs 45, 46, 47), (D) CHIKV, Chikungunya virus (Refs 47, 48), (E) JEV, Japanese encephalitis virus (Ref. 49), (F) VEEV, Venezuelan equine encephalitis virus (Ref. 47), (G) RVFV, Rift valley fever virus (Ref. 50), (H) CCHF, Crimean–Congo haemorrhagic fever (Ref. 51).
Mentions: From a public health point of view, those arboviruses that produce viremia in humans and cause major mosquito-borne epidemics are most important (Ref. 40). Figure 2 shows world geographical distribution of the most important vector-born arboviruses. In the following section we will discuss some of the most common arbovirus-induced diseases.Figure 2.

Bottom Line: Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern.The arbovirus infection and replication processes are complex, and many factors are involved in their regulation.In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes.

View Article: PubMed Central - PubMed

Affiliation: Zoonotic Diseases and Special Pathogens,National Microbiology Laboratory,Public Health Agency of Canada,1015 Arlington St.,Winnipeg,Manitoba,Canada.

ABSTRACT
Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.

No MeSH data available.


Related in: MedlinePlus